VXS
The 18F on ethyl group derivative is a PET probe C9[18F]H11NO6P [18F]-VXSO-(2-[18F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [18F]-VXS. Mouse LD50 intravenous 300 ug/kg (0.3 mg/kg)
General
Type : PET probe, Organophosphate, Derivative of Paraoxon, Derivative of VX, pNP
Chemical_Nomenclature : ethyl methyl (4-nitrophenyl) phosphate
Canonical SMILES : CCOP(=O)(OC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI : InChI=1S\/C9H12NO6P\/c1-3-15-17(13,14-2)16-9-6-4-8(5-7-9)10(11)12\/h4-7H,3H2,1-2H3
InChIKey : YOMNJRBOMBSLAR-UHFFFAOYSA-N
Other name(s) : Ethyl methyl p-nitrophenyl phosphate, BRN 2145354, H.C. 2071, Phosphoric acid, ethyl methyl p-nitrophenyl ester, DTXSID20907087, LS-107847, Phosphoric acid methylethyl 4-nitrophenyl ester, CHEMBL2115282, CHEMBL2114315
MW : 261.17
Formula : C9H12NO6P
CAS_number : 1021-47-2
PubChem : 120528
UniChem : YOMNJRBOMBSLAR-UHFFFAOYSA-N
Target
Families : VXS ligand of proteins in family
BCHE
ACHE
Protein :
human-ACHE
References (2)
| Title : Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[(18) F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [(18) F]-VXS - Hayes_2020_Ann.N.Y.Acad.Sci__ |
| Author(s) : Hayes TR , Blecha JE , Chao CK , Huynh TL , VanBrocklin HD , Zinn KR , Taylor P , Gerdes JM , Thompson CM |
| Ref : Annals of the New York Academy of Sciences , : , 2020 |
| PubMedID: 32436233 |
| Title : [Experimental myotic action of homologous and analogous diethyl-4-nitrophenyl phosphate derivatives] - |
| Author(s) : Cheymol G , Godefroy F |
| Ref : Therapie , 20 :743 , 1965 |
| PubMedID: 5840884 |