Type : Piperidine,Triazol,Azetidin
Chemical_Nomenclature : trans 1-(1-(1H-1,2,4-Triazole-1-carbonyl)piperidin-4-yl)-3,4-diphenylazetidin-2-one
Canonical SMILES : C1(C(C(N1C2CCN(CC2)C([N]3N=CN=C3)=O)=O)C4=CC=CC=C4)C5=CC=CC=C5
InChI : InChI=1S\/C23H23N5O2\/c29-22-20(17-7-3-1-4-8-17)21(18-9-5-2-6-10-18)28(22)19-11-13-26(14-12-19)23(30)27-16-24-15-25-27\/h1-10,15-16,19-21H,11-14H2
InChIKey : GUHHGBPJTRBDRL-UHFFFAOYSA-N
Other name(s) : ((+\/-)-5d)
MW : 401.46
Formula : C23H23N5O2
CAS_number :
PubChem :
UniChem : GUHHGBPJTRBDRL-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : Triazole-carbonylpiperidin-diphenylazetidin-2-one-5d ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture : 8PTC Crystal structure of human monoacylglycerol lipase in complex with compound 5d
Protein : human-MGLL
Title : Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization - Butini_2024_J.Med.Chem__ |
Author(s) : Butini S , Grether U , Jung KM , Ligresti A , Allara M , Postmus AGJ , Maramai S , Brogi S , Papa A , Carullo G , Sykes D , Veprintsev D , Federico S , Grillo A , Di Guglielmo B , Ramunno A , Stevens AF , Heer D , Lamponi S , Gemma S , Benz J , Di Marzo V , van der Stelt M , Piomelli D , Campiani G |
Ref : Journal of Medicinal Chemistry , : , 2024 |
Abstract : Butini_2024_J.Med.Chem__ |
ESTHER : Butini_2024_J.Med.Chem__ |
PubMedSearch : Butini_2024_J.Med.Chem__ |
PubMedID: 38241614 |
Gene_locus related to this paper: human-MGLL |