| Title : Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors - Kuhn_2024_J.Med.Chem__ |
| Author(s) : Kuhn B , Ritter M , Hornsperger B , Bell C , Kocer B , Rombach D , Lutz MDR , Gobbi L , Kuratli M , Bartelmus C , Burkler M , Koller R , Tosatti P , Ruf I , Guerard M , Pavlovic A , Stephanus J , O'Hara F , Wetzl D , Saal W , Stihle M , Roth D , Hug M , Huber S , Heer D , Kroll C , Topp A , Schneider M , Gertsch J , Glasmacher S , van der Stelt M , Martella A , Wittwer MB , Collin L , Benz J , Richter H , Grether U |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Kuhn_2024_J.Med.Chem__ |
| PubMedID: 39360636 |
| Title : Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization - Butini_2024_J.Med.Chem__ |
| Author(s) : Butini S , Grether U , Jung KM , Ligresti A , Allara M , Postmus AGJ , Maramai S , Brogi S , Papa A , Carullo G , Sykes D , Veprintsev D , Federico S , Grillo A , Di Guglielmo B , Ramunno A , Stevens AF , Heer D , Lamponi S , Gemma S , Benz J , Di Marzo V , van der Stelt M , Piomelli D , Campiani G |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Butini_2024_J.Med.Chem__ |
| PubMedID: 38241614 |
| Gene_locus related to this paper: human-MGLL |
| Title : Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)-[(11) C]YH132: Application in Drug Development and Neurodegenerative Diseases - He_2024_Chembiochem__e202300819 |
| Author(s) : He Y , Delparente A , Jie C , Keller C , Humm R , Heer D , Collin L , Schibli R , Gobbi L , Grether U , Mu L |
| Ref : Chembiochem , :e202300819 , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Chembiochem__e202300819 |
| PubMedID: 38441502 |
| Title : Identification of (R)-[(18)F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development - He_2023_J.Nucl.Med__ |
| Author(s) : He Y , Kramer SD , Grether U , Wittwer MB , Collin L , Kuhn B , Topp A , Heer D , O'Hara F , Honer M , Pavlovic A , Richter H , Ritter M , Rombach D , Keller C , Gobbi L , Mu L |
| Ref : J Nucl Med , : , 2023 |
| Abstract : |
| PubMedSearch : He_2023_J.Nucl.Med__ |
| PubMedID: 38164615 |
| Title : Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain - He_2022_Eur.J.Med.Chem_243_114750 |
| Author(s) : He Y , Grether U , Taddio MF , Meier C , Keller C , Edelmann MR , Honer M , Huber S , Wittwer MB , Heer D , Richter H , Collin L , Hug MN , Hilbert M , Postmus AGJ , Stevens AF , van der Stelt M , Kramer SD , Schibli R , Mu L , Gobbi LC |
| Ref : Eur Journal of Medicinal Chemistry , 243 :114750 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_Eur.J.Med.Chem_243_114750 |
| PubMedID: 36137365 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL |
| Title : A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature - Kemble_2022_PLoS.One_17_e0268590 |
| Author(s) : Kemble AM , Hornsperger B , Ruf I , Richter H , Benz J , Kuhn B , Heer D , Wittwer M , Engelhardt B , Grether U , Collin L |
| Ref : PLoS ONE , 17 :e0268590 , 2022 |
| Abstract : |
| PubMedSearch : Kemble_2022_PLoS.One_17_e0268590 |
| PubMedID: 36084029 |
| Gene_locus related to this paper: human-MGLL |
| Title : Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold - He_2022_Nucl.Med.Biol_108-109_24 |
| Author(s) : He Y , Gobbi LC , Herde AM , Rombach D , Ritter M , Kuhn B , Wittwer MB , Heer D , Hornsperger B , Bell C , O'Hara F , Benz J , Honer M , Keller C , Collin L , Richter H , Schibli R , Grether U , Mu L |
| Ref : Nucl Med Biol , 108-109 :24 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_Nucl.Med.Biol_108-109_24 |
| PubMedID: 35248850 |