Aviram M

General

Full name : Aviram Michael

First name : Michael

Mail : The Lipid Research Laboratory, Technion, Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Science, Rambam Medical Center, Haifa

Zip Code :

City :

Country : Israel

Email : aviram@tx.technion.ac.il

Phone :

Fax :

Website :

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References (115)

Title : Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression - Burillo_2016_Clin.Sci.(Lond)_130_1027
Author(s) : Burillo E , Tarin C , Torres-Fonseca MM , Fernandez-Garcia CE , Martinez-Pinna R , Martinez-Lopez D , Llamas-Granda P , Camafeita E , Lopez JA , Vega de Ceniga M , Aviram M , Egido J , Blanco-Colio LM , Martin-Ventura JL
Ref : Clinical Science (Lond) , 130 :1027 , 2016
PubMedID: 26993251

Title : Paraoxonase 1 (PON1) and pomegranate influence circadian gene expression and period length - Loizides-Mangold_2016_Chronobiol.Int_33_453
Author(s) : Loizides-Mangold U , Koren-Gluzer M , Skarupelova S , Makhlouf AM , Hayek T , Aviram M , Dibner C
Ref : Chronobiol Int , 33 :453 , 2016
PubMedID: 27010443

Title : Paraoxsonase2 (PON2) and oxidative stress involvement in pomegranate juice protection against cigarette smoke-induced macrophage cholesterol accumulation - Rom_2016_Chem.Biol.Interact_259_394
Author(s) : Rom O , Aviram M
Ref : Chemico-Biological Interactions , 259 :394 , 2016
PubMedID: 27163848

Title : Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1\/Akt pathway - Koren-Gluzer_2013_Atherosclerosis_229_71
Author(s) : Koren-Gluzer M , Aviram M , Hayek T
Ref : Atherosclerosis , 229 :71 , 2013
PubMedID: 23639858

Title : Pomegranate for your cardiovascular health - Aviram_2013_Rambam.Maimonides.Med.J_4_e0013
Author(s) : Aviram M , Rosenblat M
Ref : Rambam Maimonides Med J , 4 :e0013 , 2013
PubMedID: 23908863

Title : Monocyte-macrophage membrane possesses free radicals scavenging activity: stimulation by polyphenols or by paraoxonase 1 (PON1) - Rosenblat_2013_Free.Radic.Res_47_257
Author(s) : Rosenblat M , Elias A , Volkova N , Aviram M
Ref : Free Radical Research , 47 :257 , 2013
PubMedID: 23316782

Title : Paraoxonase 1 activities, regulation, and interactions with atherosclerotic lesion - Aviram_2013_Curr.Opin.Lipidol_24_339
Author(s) : Aviram M , Vaya J
Ref : Curr Opin Lipidol , 24 :339 , 2013
PubMedID: 23508039

Title : Pomegranate phytosterol (beta-sitosterol) and polyphenolic antioxidant (punicalagin) addition to statin, significantly protected against macrophage foam cells formation - Rosenblat_2013_Atherosclerosis_226_110
Author(s) : Rosenblat M , Volkova N , Aviram M
Ref : Atherosclerosis , 226 :110 , 2013
PubMedID: 23141585

Title : Paraoxonase 1 (PON1) reduces macrophage inflammatory responses - Aharoni_2013_Atherosclerosis_228_353
Author(s) : Aharoni S , Aviram M , Fuhrman B
Ref : Atherosclerosis , 228 :353 , 2013
PubMedID: 23582715

Title : Atherosclerosis: cell biology and lipoproteins - paraoxonases protect against atherosclerosis and diabetes development -
Author(s) : Aviram M
Ref : Curr Opin Lipidol , 23 :169 , 2012
PubMedID: 22418576

Title : Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid - Gamliel-Lazarovich_2012_Atherosclerosis_222_92
Author(s) : Gamliel-Lazarovich A , Abassi Z , Khatib S , Tavori H , Vaya J , Aviram M , Keidar S
Ref : Atherosclerosis , 222 :92 , 2012
PubMedID: 22365750

Title : Triglyceride accumulation in macrophages upregulates paraoxonase 2 (PON2) expression via ROS-mediated JNK\/c-Jun signaling pathway activation - Rosenblat_2012_Biofactors_38_458
Author(s) : Rosenblat M , Volkova N , Paland N , Aviram M
Ref : Biofactors , 38 :458 , 2012
PubMedID: 23047827

Title : VLDL triglycerides inhibit HDL-associated paraoxonase 1 (PON1) activity: in vitro and in vivo studies - Rosenblat_2012_Biofactors_38_292
Author(s) : Rosenblat M , Ward S , Volkova N , Hayek T , Aviram M
Ref : Biofactors , 38 :292 , 2012
PubMedID: 22674772

Title : Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease - Hussein_2012_Int.J.Hepatol_2012_265305
Author(s) : Hussein O , Zidan J , Abu Jabal K , Shams I , Szvalb S , Grozovski M , Bersudsky I , Karry R , Aviram M
Ref : Int Journal of Hepatology , 2012 :265305 , 2012
PubMedID: 22536512

Title : Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity - Cohen_2012_J.Lipids_2012_762560
Author(s) : Cohen E , Aviram M , Khatib S , Rabin A , Mannheim D , Karmeli R , Vaya J
Ref : J Lipids , 2012 :762560 , 2012
PubMedID: 22690338

Title : Urokinase-type plasminogen activator downregulates paraoxonase 1 expression in hepatocytes by stimulating peroxisome proliferator-activated receptor-gamma nuclear export - Khateeb_2012_Arterioscler.Thromb.Vasc.Biol_32_449
Author(s) : Khateeb J , Kiyan Y , Aviram M , Tkachuk S , Dumler I , Fuhrman B
Ref : Arterioscler Thromb Vasc Biol , 32 :449 , 2012
PubMedID: 22155455

Title : Atherosclerosis: cell biology and lipoproteins--inflammation and oxidative stress in atherogenesis: protective role for paraoxonases -
Author(s) : Aviram M
Ref : Curr Opin Lipidol , 22 :243 , 2011
PubMedID: 21562389

Title : The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates beta-cell insulin release - Koren-Gluzer_2011_Atherosclerosis_219_510
Author(s) : Koren-Gluzer M , Aviram M , Meilin E , Hayek T
Ref : Atherosclerosis , 219 :510 , 2011
PubMedID: 21862013

Title : Insulin increases macrophage triglyceride accumulation under diabetic conditions through the down regulation of hormone sensitive lipase and adipose triglyceride lipase - Meilin_2011_Biofactors_37_95
Author(s) : Meilin E , Aviram M , Hayek T
Ref : Biofactors , 37 :95 , 2011
PubMedID: 21344529

Title : Pomegranate juice protects macrophages from triglyceride accumulation: inhibitory effect on DGAT1 activity and on triglyceride biosynthesis - Rosenblat_2011_Ann.Nutr.Metab_58_1
Author(s) : Rosenblat M , Aviram M
Ref : Ann Nutr Metab , 58 :1 , 2011
PubMedID: 21212659

Title : Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis: a pilot study - Balbir-Gurman_2011_Isr.Med.Assoc.J_13_474
Author(s) : Balbir-Gurman A , Fuhrman B , Braun-Moscovici Y , Markovits D , Aviram M
Ref : Isr Med Assoc J , 13 :474 , 2011
PubMedID: 21910371

Title : Injection of paraoxonase 1 (PON1) to mice stimulates their HDL and macrophage antiatherogenicity - Rosenblat_2011_Biofactors_37_462
Author(s) : Rosenblat M , Volkova N , Aviram M
Ref : Biofactors , 37 :462 , 2011
PubMedID: 22162319

Title : Paraoxonase 1 (PON1) inhibits monocyte-to-macrophage differentiation - Rosenblat_2011_Atherosclerosis_219_49
Author(s) : Rosenblat M , Volkova N , Ward J , Aviram M
Ref : Atherosclerosis , 219 :49 , 2011
PubMedID: 21798540

Title : Paraoxonase-1 and clopidogrel efficacy -
Author(s) : Camps J , Joven J , Mackness B , Mackness MI , Tawfik DS , Draganov DI , Costa LG , Paragh G , Seres I , Horke S , James RW , Hernandez AF , Reddy ST , Shih DM , Navab M , Rochu D , Aviram M
Ref : Nat Med , 17 :1041 , 2011
PubMedID: 21900915

Title : Human carotid lesion linoleic acid hydroperoxide inhibits paraoxonase 1 (PON1) activity via reaction with PON1 free sulfhydryl cysteine 284 - Tavori_2011_Free.Radic.Biol.Med_50_148
Author(s) : Tavori H , Aviram M , Khatib S , Musa R , Mannheim D , Karmeli R , Vaya J
Ref : Free Radic Biol Med , 50 :148 , 2011
PubMedID: 21044882

Title : Paraoxonase 1 protects macrophages from atherogenicity of a specific triglyceride isolated from human carotid lesion - Tavori_2011_Free.Radic.Biol.Med_51_234
Author(s) : Tavori H , Aviram M , Khatib S , Musa R , Mannheim D , Karmeli R , Vaya J
Ref : Free Radic Biol Med , 51 :234 , 2011
PubMedID: 21530644

Title : Atherosclerosis: cell biology and lipoproteins--oxidative stress and paraoxonases regulate atherogenesis -
Author(s) : Aviram M
Ref : Curr Opin Lipidol , 21 :163 , 2010
PubMedID: 20616631

Title : Paraoxonase 1 (PON1) deficiency in mice is associated with reduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis - Fuhrman_2010_Atherosclerosis_211_61
Author(s) : Fuhrman B , Gantman A , Aviram M
Ref : Atherosclerosis , 211 :61 , 2010
PubMedID: 20149374

Title : Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients - Fuhrman_2010_Nutrition_26_359
Author(s) : Fuhrman B , Volkova N , Aviram M
Ref : Nutrition , 26 :359 , 2010
PubMedID: 19762215

Title : ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I - Gaidukov_2010_Biochemistry_49_532
Author(s) : Gaidukov L , Viji RI , Yacobson S , Rosenblat M , Aviram M , Tawfik DS
Ref : Biochemistry , 49 :532 , 2010
PubMedID: 20025294

Title : Paraoxonase 1 deficiency in mice is associated with reduced steroid biosynthesis: effects on HDL binding, cholesteryl ester accumulation and scavenger receptor type BI expression - Gamliel-Lazarovich_2010_Atherosclerosis_211_130
Author(s) : Gamliel-Lazarovich A , Gantman A , Shiner M , Coleman R , Aviram M , Keidar S
Ref : Atherosclerosis , 211 :130 , 2010
PubMedID: 20189567

Title : Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum's ability to attenuate macrophage cholesterol accumulation - Rosenblat_2010_Food.Funct_1_99
Author(s) : Rosenblat M , Volkova N , Attias J , Mahamid R , Aviram M
Ref : Food Funct , 1 :99 , 2010
PubMedID: 21776460

Title : Macrophage endoplasmic reticulum (ER) proteins and reducing elements stabilize paraoxonase 2 (PON2) - Rosenblat_2010_Atherosclerosis_213_408
Author(s) : Rosenblat M , Volkova N , Aviram M
Ref : Atherosclerosis , 213 :408 , 2010
PubMedID: 21036357

Title : Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2 - Rosenblat_2010_Atherosclerosis_212_86
Author(s) : Rosenblat M , Volkova N , Aviram M
Ref : Atherosclerosis , 212 :86 , 2010
PubMedID: 20537330

Title : Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid - Rosenblat_2010_Atherosclerosis_210_414
Author(s) : Rosenblat M , Volkova N , Roqueta-Rivera M , Nakamura MT , Aviram M
Ref : Atherosclerosis , 210 :414 , 2010
PubMedID: 20042190

Title : Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: studies in PON2-deficient mice - Meilin_2010_Atherosclerosis_208_390
Author(s) : Meilin E , Aviram M , Hayek T
Ref : Atherosclerosis , 208 :390 , 2010
PubMedID: 19748094

Title : Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway - Khateeb_2010_Atherosclerosis_208_119
Author(s) : Khateeb J , Gantman A , Kreitenberg AJ , Aviram M , Fuhrman B
Ref : Atherosclerosis , 208 :119 , 2010
PubMedID: 19783251

Title : Paraoxonase 1 attenuates human plaque atherogenicity: relevance to the enzyme lactonase activity - Tavori_2010_Adv.Exp.Med.Biol_660_99
Author(s) : Tavori H , Vaya J , Aviram M
Ref : Advances in Experimental Medicine & Biology , 660 :99 , 2010
PubMedID: 20221874

Title : Paraoxonase 1 interactions with HDL, antioxidants and macrophages regulate atherogenesis - a protective role for HDL phospholipids - Efrat_2010_Adv.Exp.Med.Biol_660_153
Author(s) : Efrat M , Aviram M
Ref : Advances in Experimental Medicine & Biology , 660 :153 , 2010
PubMedID: 20221878

Title : Effects of date ( Phoenix dactylifera L., Medjool or Hallawi Variety) consumption by healthy subjects on serum glucose and lipid levels and on serum oxidative status: a pilot study - Rock_2009_J.Agric.Food.Chem_57_8010
Author(s) : Rock W , Rosenblat M , Borochov-Neori H , Volkova N , Judeinstein S , Elias M , Aviram M
Ref : Journal of Agricultural and Food Chemistry , 57 :8010 , 2009
PubMedID: 19681613

Title : Urokinase activates macrophage PON2 gene transcription via the PI3K\/ROS\/MEK\/SREBP-2 signalling cascade mediated by the PDGFR-beta - Fuhrman_2009_Cardiovasc.Res_84_145
Author(s) : Fuhrman B , Gantman A , Khateeb J , Volkova N , Horke S , Kiyan J , Dumler I , Aviram M
Ref : Cardiovascular Research , 84 :145 , 2009
PubMedID: 19497963

Title : Paraoxonases role in the prevention of cardiovascular diseases - Rosenblat_2009_Biofactors_35_98
Author(s) : Rosenblat M , Aviram M
Ref : Biofactors , 35 :98 , 2009
PubMedID: 19319852

Title : Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1 - Rosenblat_2009_J.Lipid.Res_50_870
Author(s) : Rosenblat M , Coleman R , Reddy ST , Aviram M
Ref : J Lipid Res , 50 :870 , 2009
PubMedID: 19091699

Title : Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development - Wilund_2009_Biochem.Biophys.Res.Commun_390_148
Author(s) : Wilund KR , Rosenblat M , Chung HR , Volkova N , Kaplan M , Woods JA , Aviram M
Ref : Biochemical & Biophysical Research Communications , 390 :148 , 2009
PubMedID: 19785985

Title : Lipid profile and serum characteristics of the blind subterranean mole rat, Spalax - Nasser_2009_PLoS.One_4_e4528
Author(s) : Nasser NJ , Kaplan M , Nevo E , Aviram M
Ref : PLoS ONE , 4 :e4528 , 2009
PubMedID: 19229331

Title : Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor\/consensus mutagenesis, and its biochemical characterization - Khersonsky_2009_Biochemistry_48_6644
Author(s) : Khersonsky O , Rosenblat M , Toker L , Yacobson S , Hugenmatter A , Silman I , Sussman JL , Aviram M , Tawfik DS
Ref : Biochemistry , 48 :6644 , 2009
PubMedID: 19492856

Title : Human carotid atherosclerotic plaque increases oxidative state of macrophages and low-density lipoproteins, whereas paraoxonase 1 (PON1) decreases such atherogenic effects - Tavori_2009_Free.Radic.Biol.Med_46_607
Author(s) : Tavori H , Aviram M , Khatib S , Musa R , Nitecki S , Hoffman A , Vaya J
Ref : Free Radic Biol Med , 46 :607 , 2009
PubMedID: 19103284

Title : Di-oleoyl phosphatidylcholine (PC-18:1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies - Efrat_2009_Atherosclerosis_202_461
Author(s) : Efrat M , Rosenblat M , Mahmood S , Vaya J , Aviram M
Ref : Atherosclerosis , 202 :461 , 2009
PubMedID: 18585720

Title : Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities - Rock_2008_J.Agric.Food.Chem_56_8704
Author(s) : Rock W , Rosenblat M , Miller-Lotan R , Levy AP , Elias M , Aviram M
Ref : Journal of Agricultural and Food Chemistry , 56 :8704 , 2008
PubMedID: 18759451

Title : Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism - Fuhrman_2008_Arterioscler.Thromb.Vasc.Biol_28_1361
Author(s) : Fuhrman B , Khateeb J , Shiner M , Nitzan O , Karry R , Volkova N , Aviram M
Ref : Arterioscler Thromb Vasc Biol , 28 :1361 , 2008
PubMedID: 18436804

Title : Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases - Aviram_2008_Methods.Mol.Biol_477_259
Author(s) : Aviram M , Rosenblat M
Ref : Methods Mol Biol , 477 :259 , 2008
PubMedID: 19082953

Title : Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins - Aviram_2008_J.Agric.Food.Chem_56_1148
Author(s) : Aviram M , Volkova N , Coleman R , Dreher M , Reddy MK , Ferreira D , Rosenblat M
Ref : Journal of Agricultural and Food Chemistry , 56 :1148 , 2008
PubMedID: 18173244

Title : Antiatherogenicity of extra virgin olive oil and its enrichment with green tea polyphenols in the atherosclerotic apolipoprotein-E-deficient mice: enhanced macrophage cholesterol efflux - Rosenblat_2008_J.Nutr.Biochem_19_514
Author(s) : Rosenblat M , Volkova N , Coleman R , Almagor Y , Aviram M
Ref : J Nutr Biochem , 19 :514 , 2008
PubMedID: 17904345

Title : Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties - Rozenberg_2008_Free.Radic.Biol.Med_44_1951
Author(s) : Rozenberg O , Shiner M , Aviram M , Hayek T
Ref : Free Radic Biol Med , 44 :1951 , 2008
PubMedID: 18358245

Title : Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity - Tavori_2008_Bioorg.Med.Chem_16_7504
Author(s) : Tavori H , Khatib S , Aviram M , Vaya J
Ref : Bioorganic & Medicinal Chemistry , 16 :7504 , 2008
PubMedID: 18572410

Title : Macrophage paraoxonase 1 (PON1) binding sites - Efrat_2008_Biochem.Biophys.Res.Commun_376_105
Author(s) : Efrat M , Aviram M
Ref : Biochemical & Biophysical Research Communications , 376 :105 , 2008
PubMedID: 18762170

Title : Consumption of a novel dietary formula of plant sterol esters of canola oil fatty acids, in a canola oil matrix containing 1,3-diacylglycerol, reduces oxidative stress in atherosclerotic apolipoprotein E-deficient mice - Fuhrman_2007_J.Agric.Food.Chem_55_2028
Author(s) : Fuhrman B , Plat D , Herzog Y , Aviram M
Ref : Journal of Agricultural and Food Chemistry , 55 :2028 , 2007
PubMedID: 17284051

Title : Anti-oxidant and anti-atherogenic properties of liposomal glutathione: studies in vitro, and in the atherosclerotic apolipoprotein E-deficient mice - Rosenblat_2007_Atherosclerosis_195_e61
Author(s) : Rosenblat M , Volkova N , Coleman R , Aviram M
Ref : Atherosclerosis , 195 :e61 , 2007
PubMedID: 17588583

Title : Macrophage NADPH oxidase activation, impaired cholesterol fluxes, and increased cholesterol biosynthesis in diabetic mice: a stimulatory role for D-glucose - Hayek_2007_Atherosclerosis_195_277
Author(s) : Hayek T , Kaplan M , Kerry R , Aviram M
Ref : Atherosclerosis , 195 :277 , 2007
PubMedID: 17258748

Title : Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation - Shiner_2007_Atherosclerosis_195_313
Author(s) : Shiner M , Fuhrman B , Aviram M
Ref : Atherosclerosis , 195 :313 , 2007
PubMedID: 17292903

Title : Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol 3-kinase (PI3K) pathway - Shiner_2007_Biol.Chem_388_1353
Author(s) : Shiner M , Fuhrman B , Aviram M
Ref : Biol Chem , 388 :1353 , 2007
PubMedID: 18020951

Title : HDL--associated paraoxonase 1 (PON1) and dietary antioxidants attenuate lipoprotein oxidation, macrophage foam cells formation and atherosclerosis development -
Author(s) : Aviram M
Ref : Pathophysiol Haemost Thromb , 35 :146 , 2006
PubMedID: 16855361

Title : Postprandial serum triacylglycerols and oxidative stress in mice after consumption of fish oil, soy oil or olive oil: possible role for paraoxonase-1 triacylglycerol lipase-like activity - Fuhrman_2006_Nutrition_22_922
Author(s) : Fuhrman B , Volkova N , Aviram M
Ref : Nutrition , 22 :922 , 2006
PubMedID: 16814984

Title : The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux - Rosenblat_2006_J.Biol.Chem_281_7657
Author(s) : Rosenblat M , Gaidukov L , Khersonsky O , Vaya J , Oren R , Tawfik DS , Aviram M
Ref : Journal of Biological Chemistry , 281 :7657 , 2006
PubMedID: 16407304

Title : The 192R\/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux - Gaidukov_2006_J.Lipid.Res_47_2492
Author(s) : Gaidukov L , Rosenblat M , Aviram M , Tawfik DS
Ref : J Lipid Res , 47 :2492 , 2006
PubMedID: 16914770

Title : Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages - Rosenblat_2006_Atherosclerosis_187_363
Author(s) : Rosenblat M , Hayek T , Aviram M
Ref : Atherosclerosis , 187 :363 , 2006
PubMedID: 16226266

Title : Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes - Rosenblat_2006_Atherosclerosis_187_74
Author(s) : Rosenblat M , Karry R , Aviram M
Ref : Atherosclerosis , 187 :74 , 2006
PubMedID: 16229851

Title : Lysophosphatidylcholine (LPC) attenuates macrophage-mediated oxidation of LDL - Rosenblat_2006_Biochem.Biophys.Res.Commun_344_1271
Author(s) : Rosenblat M , Oren R , Aviram M
Ref : Biochemical & Biophysical Research Communications , 344 :1271 , 2006
PubMedID: 16650824

Title : Pomegranate byproduct administration to apolipoprotein e-deficient mice attenuates atherosclerosis development as a result of decreased macrophage oxidative stress and reduced cellular uptake of oxidized low-density lipoprotein - Rosenblat_2006_J.Agric.Food.Chem_54_1928
Author(s) : Rosenblat M , Volkova N , Coleman R , Aviram M
Ref : Journal of Agricultural and Food Chemistry , 54 :1928 , 2006
PubMedID: 16506855

Title : Effect of a Mediterranean meal on postprandial carotenoids, paraoxonase activity and C-reactive protein levels - Blum_2006_Ann.Nutr.Metab_50_20
Author(s) : Blum S , Aviram M , Ben-Amotz A , Levy Y
Ref : Ann Nutr Metab , 50 :20 , 2006
PubMedID: 16276071

Title : S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity - Rozenberg_2006_Biochem.Biophys.Res.Commun_351_492
Author(s) : Rozenberg O , Aviram M
Ref : Biochemical & Biophysical Research Communications , 351 :492 , 2006
PubMedID: 17070779

Title : Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it - Rozenberg_2006_Atherosclerosis_188_68
Author(s) : Rozenberg O , Howell A , Aviram M
Ref : Atherosclerosis , 188 :68 , 2006
PubMedID: 16332370

Title : A biphasic U-shape effect of cellular oxidative stress on the macrophage anti-oxidant paraoxonase 2 (PON2) enzymatic activity - Shiner_2006_Biochem.Biophys.Res.Commun_349_1094
Author(s) : Shiner M , Fuhrman B , Aviram M
Ref : Biochemical & Biophysical Research Communications , 349 :1094 , 2006
PubMedID: 16970920

Title : Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development - Aviram_2005_Handb.Exp.Pharmacol_170_263
Author(s) : Aviram M , Kaplan M , Rosenblat M , Fuhrman B
Ref : Handbook of Experimental Pharmacology , 170 :263 , 2005
PubMedID: 16596803

Title : Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences - Aviram_2005_Curr.Opin.Lipidol_16_393
Author(s) : Aviram M , Rosenblat M
Ref : Curr Opin Lipidol , 16 :393 , 2005
PubMedID: 15990587

Title : Paraoxonase 1 (PON1) is present in postprandial chylomicrons - Fuhrman_2005_Atherosclerosis_180_55
Author(s) : Fuhrman B , Volkova N , Aviram M
Ref : Atherosclerosis , 180 :55 , 2005
PubMedID: 15823275

Title : Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine - Rosenblat_2005_Atherosclerosis_179_69
Author(s) : Rosenblat M , Vaya J , Shih DM , Aviram M
Ref : Atherosclerosis , 179 :69 , 2005
PubMedID: 15721011

Title : Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice - Rozenberg_2005_Atherosclerosis_181_9
Author(s) : Rozenberg O , Shih DM , Aviram M
Ref : Atherosclerosis , 181 :9 , 2005
PubMedID: 15939049

Title : Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2 - Shamir_2005_Free.Radic.Biol.Med_39_336
Author(s) : Shamir R , Hartman C , Karry R , Pavlotzky E , Eliakim R , Lachter J , Suissa A , Aviram M
Ref : Free Radic Biol Med , 39 :336 , 2005
PubMedID: 15993332

Title : Introduction to the serial review on paraoxonases, oxidative stress, and cardiovascular diseases -
Author(s) : Aviram M
Ref : Free Radic Biol Med , 37 :1301 , 2004
PubMedID: 15454270

Title : Acetylcholine esterase protects LDL against oxidation - Fuhrman_2004_Biochem.Biophys.Res.Commun_322_974
Author(s) : Fuhrman B , Partoush A , Aviram M
Ref : Biochemical & Biophysical Research Communications , 322 :974 , 2004
PubMedID: 15336559

Title : Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development - Aviram_2004_Free.Radic.Biol.Med_37_1304
Author(s) : Aviram M , Rosenblat M
Ref : Free Radic Biol Med , 37 :1304 , 2004
PubMedID: 15454271

Title : Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation - Aviram_2004_Clin.Nutr_23_423
Author(s) : Aviram M , Rosenblat M , Gaitini D , Nitecki S , Hoffman A , Dornfeld L , Volkova N , Presser D , Attias J , Liker H , Hayek T
Ref : Clin Nutr , 23 :423 , 2004
PubMedID: 15158307

Title : Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy - Rosenblat_2004_Arterioscler.Thromb.Vasc.Biol_24_175
Author(s) : Rosenblat M , Hayek T , Hussein K , Aviram M
Ref : Arterioscler Thromb Vasc Biol , 24 :175 , 2004
PubMedID: 14592851

Title : Omapatrilat decreased macrophage oxidative status and atherosclerosis progression in atherosclerotic apolipoprotein E-deficient mice - Hayek_2004_J.Cardiovasc.Pharmacol_43_140
Author(s) : Hayek T , Hamoud S , Keidar S , Pavlotzky E , Coleman R , Aviram M , Kaplan M
Ref : J Cardiovasc Pharmacol , 43 :140 , 2004
PubMedID: 14668580

Title : Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages - Shiner_2004_Free.Radic.Biol.Med_37_2052
Author(s) : Shiner M , Fuhrman B , Aviram M
Ref : Free Radic Biol Med , 37 :2052 , 2004
PubMedID: 15544923

Title : Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress - Rosenblat_2003_Arterioscler.Thromb.Vasc.Biol_23_468
Author(s) : Rosenblat M , Draganov DI , Watson CE , Bisgaier CL , La Du BN , Aviram M
Ref : Arterioscler Thromb Vasc Biol , 23 :468 , 2003
PubMedID: 12615656

Title : Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice - Rozenberg_2003_Free.Radic.Biol.Med_34_774
Author(s) : Rozenberg O , Rosenblat M , Coleman R , Shih DM , Aviram M
Ref : Free Radic Biol Med , 34 :774 , 2003
PubMedID: 12633754

Title : Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation - Rozenberg_2003_Arterioscler.Thromb.Vasc.Biol_23_461
Author(s) : Rozenberg O , Shih DM , Aviram M
Ref : Arterioscler Thromb Vasc Biol , 23 :461 , 2003
PubMedID: 12615663

Title : Tissue angiotensin-converting-enzyme (ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis: studies in ACE-knockout mice type 2 - Hayek_2003_Arterioscler.Thromb.Vasc.Biol_23_2090
Author(s) : Hayek T , Pavlotzky E , Hamoud S , Coleman R , Keidar S , Aviram M , Kaplan M
Ref : Arterioscler Thromb Vasc Biol , 23 :2090 , 2003
PubMedID: 14525797

Title : Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice - Keidar_2003_J.Cardiovasc.Pharmacol_41_955
Author(s) : Keidar S , Hayek T , Kaplan M , Pavlotzky E , Hamoud S , Coleman R , Aviram M
Ref : J Cardiovasc Pharmacol , 41 :955 , 2003
PubMedID: 12775976

Title : Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation - Fuhrman_2002_Ann.N.Y.Acad.Sci_957_321
Author(s) : Fuhrman B , Aviram M
Ref : Annals of the New York Academy of Sciences , 957 :321 , 2002
PubMedID: 12074989

Title : Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans - Aviram_2002_Drugs.Exp.Clin.Res_28_49
Author(s) : Aviram M , Dornfeld L , Kaplan M , Coleman R , Gaitini D , Nitecki S , Hofman A , Rosenblat M , Volkova N , Presser D , Attias J , Hayek T , Fuhrman B
Ref : Drugs Under Experimental & Clinical Research , 28 :49 , 2002
PubMedID: 12224378

Title : Wine flavonoids protect against LDL oxidation and atherosclerosis - Aviram_2002_Ann.N.Y.Acad.Sci_957_146
Author(s) : Aviram M , Fuhrman B
Ref : Annals of the New York Academy of Sciences , 957 :146 , 2002
PubMedID: 12074969

Title : Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes - Fuhrman_2002_Atherosclerosis_164_179
Author(s) : Fuhrman B , Koren L , Volkova N , Keidar S , Hayek T , Aviram M
Ref : Atherosclerosis , 164 :179 , 2002
PubMedID: 12119208

Title : Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase - Fuhrman_2002_Atherosclerosis_161_307
Author(s) : Fuhrman B , Volkova N , Aviram M
Ref : Atherosclerosis , 161 :307 , 2002
PubMedID: 11888513

Title : Serum paraoxonase activity and the extent of lipid peroxidation are not affected by increased levels of human apolipoprotein A-I: studies in transgenic mice - Rosenblat_2002_Clin.Chem.Lab.Med_40_9
Author(s) : Rosenblat M , Grunfeld O , Hayek T , Aviram M
Ref : Clinical Chemistry & Laboratory Medicine , 40 :9 , 2002
PubMedID: 11916277

Title : Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis - Kaplan_2001_J.Nutr_131_2082
Author(s) : Kaplan M , Hayek T , Raz A , Coleman R , Dornfeld L , Vaya J , Aviram M
Ref : J Nutr , 131 :2082 , 2001
PubMedID: 11481398

Title : Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases - Aviram_2000_Free.Radic.Res_33 Suppl_S85
Author(s) : Aviram M
Ref : Free Radical Research , 33 Suppl :S85 , 2000
PubMedID: 11191279

Title : Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice - Aviram_2000_Am.J.Clin.Nutr_71_1062
Author(s) : Aviram M , Dornfeld L , Rosenblat M , Volkova N , Kaplan M , Coleman R , Hayek T , Presser D , Fuhrman B
Ref : Am J Clin Nutr , 71 :1062 , 2000
PubMedID: 10799367

Title : Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities - Aviram_2000_Circulation_101_2510
Author(s) : Aviram M , Hardak E , Vaya J , Mahmood S , Milo S , Hoffman A , Billicke S , Draganov DI , Rosenblat M
Ref : Circulation , 101 :2510 , 2000
PubMedID: 10831526

Title : Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants - Aviram_1999_Free.Radic.Biol.Med_26_892
Author(s) : Aviram M , Rosenblat M , Billecke S , Erogul J , Sorenson R , Bisgaier CL , Newton RS , La Du BN
Ref : Free Radic Biol Med , 26 :892 , 1999
PubMedID: 10232833

Title : Properties of the retained N-terminal hydrophobic leader sequence in human serum paraoxonase\/arylesterase - Sorenson_1999_Chem.Biol.Interact_119-120_243
Author(s) : Sorenson RC , Aviram M , Bisgaier CL , Billecke S , Hsu C , La Du BN
Ref : Chemico-Biological Interactions , 119-120 :243 , 1999
PubMedID: 10421458

Title : On the physiological role(s) of the paraoxonases - La Du_1999_Chem.Biol.Interact_119-120_379
Author(s) : La Du BN , Aviram M , Billecke S , Navab M , Primo-Parmo S , Sorenson RC , Standiford TJ
Ref : Chemico-Biological Interactions , 119-120 :379 , 1999
PubMedID: 10421474

Title : Oxidized low density lipoprotein: atherogenic and proinflammatory characteristics during macrophage foam cell formation. An inhibitory role for nutritional antioxidants and serum paraoxonase - Kaplan_1999_Clin.Chem.Lab.Med_37_777
Author(s) : Kaplan M , Aviram M
Ref : Clinical Chemistry & Laboratory Medicine , 37 :777 , 1999
PubMedID: 10536926

Title : Human serum Paraoxonase\/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity - Sorenson_1999_Arterioscler.Thromb.Vasc.Biol_19_2214
Author(s) : Sorenson RC , Bisgaier CL , Aviram M , Hsu C , Billecke S , La Du BN
Ref : Arterioscler Thromb Vasc Biol , 19 :2214 , 1999
PubMedID: 10479665

Title : [Cholesterol oxidation, macrophage foam cells and atherosclerosis: importance of antioxidants and paraoxonase] -
Author(s) : Aviram M
Ref : Harefuah , 136 :620 , 1999
PubMedID: 10955072

Title : Does paraoxonase play a role in susceptibility to cardiovascular disease? - Aviram_1999_Mol.Med.Today_5_381
Author(s) : Aviram M
Ref : Mol Med Today , 5 :381 , 1999
PubMedID: 10462749

Title : Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins - Aviram_1999_Antioxid.Redox.Signal_1_585
Author(s) : Aviram M
Ref : Antioxid Redox Signal , 1 :585 , 1999
PubMedID: 11233155

Title : Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase\/paraoxonase activities: selective action of human paraoxonase allozymes Q and R - Aviram_1998_Arterioscler.Thromb.Vasc.Biol_18_1617
Author(s) : Aviram M , Billecke S , Sorenson R , Bisgaier C , Newton R , Rosenblat M , Erogul J , Hsu C , Dunlop C , La Du BN
Ref : Arterioscler Thromb Vasc Biol , 18 :1617 , 1998
PubMedID: 9763535

Title : LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: role of prooxidants vs. antioxidants - Aviram_1998_Mol.Cell.Biochem_188_149
Author(s) : Aviram M , Fuhrman B
Ref : Molecular & Cellular Biochemistry , 188 :149 , 1998
PubMedID: 9823020

Title : Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation - Aviram_1998_Atherosclerosis_138_271
Author(s) : Aviram M , Rosenblat M , Bisgaier CL , Newton RS
Ref : Atherosclerosis , 138 :271 , 1998
PubMedID: 9690910

Title : Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase - Aviram_1998_J.Clin.Invest_101_1581
Author(s) : Aviram M , Rosenblat M , Bisgaier CL , Newton RS , Primo-Parmo SL , La Du BN
Ref : J Clinical Investigation , 101 :1581 , 1998
PubMedID: 9541487

Title : Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation - Hayek_1997_Arterioscler.Thromb.Vasc.Biol_17_2744
Author(s) : Hayek T , Fuhrman B , Vaya J , Rosenblat M , Belinky P , Coleman R , Elis A , Aviram M
Ref : Arterioscler Thromb Vasc Biol , 17 :2744 , 1997
PubMedID: 9409251

Title : Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells - Aviram_1988_J.Biol.Chem_263_15416
Author(s) : Aviram M , Bierman EL , Chait A
Ref : Journal of Biological Chemistry , 263 :15416 , 1988
PubMedID: 3170589