Danks MK

References (39)

Title : An improved human carboxylesterase for enzyme\/prodrug therapy with CPT-11 - Wierdl_2008_Cancer.Gene.Ther_15_183
Author(s) : Wierdl M , Tsurkan L , Hyatt JL , Edwards CC , Hatfield MJ , Morton CL , Houghton PJ , Danks MK , Redinbo MR , Potter PM
Ref : Cancer Gene Therapy , 15 :183 , 2008
PubMedID: 18188187

Title : Stem and progenitor cell-mediated tumor selective gene therapy - Aboody_2008_Gene.Ther_15_739
Author(s) : Aboody KS , Najbauer J , Danks MK
Ref : Gene Therapy , 15 :739 , 2008
PubMedID: 18369324

Title : Tumor-targeted enzyme\/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma - Danks_2007_Cancer.Res_67_22
Author(s) : Danks MK , Yoon KJ , Bush RA , Remack JS , Wierdl M , Tsurkan L , Kim SU , Garcia E , Metz MZ , Najbauer J , Potter PM , Aboody KS
Ref : Cancer Research , 67 :22 , 2007
PubMedID: 17210679

Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876
Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM
Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007
PubMedID: 17378546

Title : Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1 - Hyatt_2007_J.Med.Chem_50_5727
Author(s) : Hyatt JL , Wadkins RM , Tsurkan L , Hicks LD , Hatfield MJ , Edwards CC , Ross CR, 2nd , Cantalupo SA , Crundwell G , Danks MK , Guy RK , Potter PM
Ref : Journal of Medicinal Chemistry , 50 :5727 , 2007
PubMedID: 17941623

Title : Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy - Yoon_2006_Mol.Cancer.Ther_5_1577
Author(s) : Yoon KJ , Qi J , Remack JS , Virga KG , Hatfield MJ , Potter PM , Lee RE , Danks MK
Ref : Mol Cancer Ther , 5 :1577 , 2006
PubMedID: 16818517

Title : Development of a tumor-selective approach to treat metastatic cancer - Aboody_2006_PLoS.One_1_e23
Author(s) : Aboody KS , Bush RA , Garcia E , Metz MZ , Najbauer J , Justus KA , Phelps DA , Remack JS , Yoon KJ , Gillespie S , Kim SU , Glackin CA , Potter PM , Danks MK
Ref : PLoS ONE , 1 :e23 , 2006
PubMedID: 17183650

Title : Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity - Hyatt_2006_Mol.Cancer.Ther_5_2281
Author(s) : Hyatt JL , Tsurkan L , Wierdl M , Edwards CC , Danks MK , Potter PM
Ref : Mol Cancer Ther , 5 :2281 , 2006
PubMedID: 16985062

Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906
Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM
Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005
PubMedID: 15828829

Title : Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan - Tyminski_2005_Cancer.Res_65_6850
Author(s) : Tyminski E , Leroy S , Terada K , Finkelstein DM , Hyatt JL , Danks MK , Potter PM , Saeki Y , Chiocca EA
Ref : Cancer Research , 65 :6850 , 2005
PubMedID: 16061668

Title : Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice - Morton_2005_Cancer.Chemother.Pharmacol_56_629
Author(s) : Morton CL , Iacono L , Hyatt JL , Taylor KR , Cheshire PJ , Houghton PJ , Danks MK , Stewart CF , Potter PM
Ref : Cancer Chemother Pharmacol , 56 :629 , 2005
PubMedID: 15918039

Title : Development of prodrugs for enzyme-mediated, tumor-selective therapy - Yoon_2005_Curr.Med.Chem.Anticancer.Agents_5_107
Author(s) : Yoon KJ , Potter PM , Danks MK
Ref : Curr Med Chem Anticancer Agents , 5 :107 , 2005
PubMedID: 15777218

Title : Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety - Hyatt_2005_J.Med.Chem_48_5543
Author(s) : Hyatt JL , Stacy V , Wadkins RM , Yoon KJ , Wierdl M , Edwards CC , Zeller M , Hunter AD , Danks MK , Crundwell G , Potter PM
Ref : Journal of Medicinal Chemistry , 48 :5543 , 2005
PubMedID: 16107154

Title : Enzyme-prodrug systems: carboxylesterase\/CPT-11 -
Author(s) : Danks MK , Potter PM
Ref : Methods Mol Med , 90 :247 , 2004
PubMedID: 14657567

Title : Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application - Yoon_2004_Mol.Cancer.Ther_3_903
Author(s) : Yoon KJ , Hyatt JL , Morton CL , Lee RE , Potter PM , Danks MK
Ref : Mol Cancer Ther , 3 :903 , 2004
PubMedID: 15299073

Title : Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity - Wadkins_2004_Mol.Pharmacol_65_1336
Author(s) : Wadkins RM , Hyatt JL , Yoon KJ , Morton CL , Lee RE , Damodaran K , Beroza P , Danks MK , Potter PM
Ref : Molecular Pharmacology , 65 :1336 , 2004
PubMedID: 15155827

Title : Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies - Yoon_2003_Mol.Cancer.Ther_2_1171
Author(s) : Yoon KJ , Krull EJ , Morton CL , Bornmann WG , Lee RE , Potter PM , Danks MK
Ref : Mol Cancer Ther , 2 :1171 , 2003
PubMedID: 14617791

Title : Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism - Yoon_2003_Bioorg.Med.Chem_11_3237
Author(s) : Yoon KJ , Morton CL , Potter PM , Danks MK , Lee RE
Ref : Bioorganic & Medicinal Chemistry , 11 :3237 , 2003
PubMedID: 12837533

Title : A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38 - Stubdal_2003_Cancer.Res_63_6900
Author(s) : Stubdal H , Perin N , Lemmon M , Holman P , Bauzon M , Potter PM , Danks MK , Fattaey A , Dubensky T , Johnson L
Ref : Cancer Research , 63 :6900 , 2003
PubMedID: 14583489

Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341
Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR
Ref : Chemical Biology , 10 :341 , 2003
PubMedID: 12725862
Gene_locus related to this paper: human-CES1

Title : p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) - Wierdl_2003_J.Pharmacol.Exp.Ther_304_699
Author(s) : Wierdl M , Morton CL , Harris LC , Danks MK , Schuetz JD , Potter PM
Ref : Journal of Pharmacology & Experimental Therapeutics , 304 :699 , 2003
PubMedID: 12538824

Title : Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance - Wierdl_2003_Mol.Pharmacol_64_279
Author(s) : Wierdl M , Wall A , Morton CL , Sampath J , Danks MK , Schuetz JD , Potter PM
Ref : Molecular Pharmacology , 64 :279 , 2003
PubMedID: 12869632

Title : Structural insights into CPT-11 activation by mammalian carboxylesterases - Bencharit_2002_Nat.Struct.Biol_9_337
Author(s) : Bencharit S , Morton CL , Howard-Williams EL , Danks MK , Potter PM , Redinbo MR
Ref : Nat Struct Biol , 9 :337 , 2002
PubMedID: 11967565
Gene_locus related to this paper: rabit-1cxes

Title : Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients - Wagner_2002_Cancer.Res_62_5001
Author(s) : Wagner LM , Guichard SM , Burger RA , Morton CL , Straign CM , Ashmun RA , Harris LC , Houghton PJ , Potter PM , Danks MK
Ref : Cancer Research , 62 :5001 , 2002
PubMedID: 12208753

Title : A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11 - Meck_2001_Cancer.Res_61_5083
Author(s) : Meck MM , Wierdl M , Wagner LM , Burger RA , Guichard SM , Krull EJ , Harris LC , Potter PM , Danks MK
Ref : Cancer Research , 61 :5083 , 2001
PubMedID: 11431345

Title : Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression - Iyengar_2001_Cancer.Res_61_3045
Author(s) : Iyengar RV , Pawlik CA , Krull EJ , Phelps DA , Burger RA , Harris LC , Potter PM , Danks MK
Ref : Cancer Research , 61 :3045 , 2001
PubMedID: 11306486

Title : Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases - Wadkins_2001_Mol.Pharmacol_60_355
Author(s) : Wadkins RM , Morton CL , Weeks JK , Oliver L , Wierdl M , Danks MK , Potter PM
Ref : Molecular Pharmacology , 60 :355 , 2001
PubMedID: 11455023

Title : Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase - Wierdl_2001_Cancer.Res_61_5078
Author(s) : Wierdl M , Morton CL , Weeks JK , Danks MK , Harris LC , Potter PM
Ref : Cancer Research , 61 :5078 , 2001
PubMedID: 11431344

Title : Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11 - Pawlik_2000_Mol.Ther_1_457
Author(s) : Pawlik CA , Iyengar RV , Krull EJ , Mason SE , Khanna R , Harris LC , Potter PM , Danks MK , Guichard SM
Ref : Mol Ther , 1 :457 , 2000
PubMedID: 10933967

Title : Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase - Morton_2000_Cancer.Res_60_4206
Author(s) : Morton CL , Wierdl M , Oliver L , Ma MK , Danks MK , Stewart CF , Eiseman JL , Potter PM
Ref : Cancer Research , 60 :4206 , 2000
PubMedID: 10945631

Title : Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation - Wierdl_2000_Biochem.Pharmacol_59_773
Author(s) : Wierdl M , Morton CL , Danks MK , Potter PM
Ref : Biochemical Pharmacology , 59 :773 , 2000
PubMedID: 10718335
Gene_locus related to this paper: horse-BCHE

Title : Proficient metabolism of irinotecan by a human intestinal carboxylesterase - Khanna_2000_Cancer.Res_60_4725
Author(s) : Khanna R , Morton CL , Danks MK , Potter PM
Ref : Cancer Research , 60 :4725 , 2000
PubMedID: 10987276

Title : Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme\/prodrug therapy - Danks_1999_Clin.Cancer.Res_5_917
Author(s) : Danks MK , Morton CL , Krull EJ , Cheshire PJ , Richmond LB , Naeve CW , Pawlik CA , Houghton PJ , Potter PM
Ref : Clin Cancer Research , 5 :917 , 1999
PubMedID: 10213229

Title : The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase - Morton_1999_Cancer.Res_59_1458
Author(s) : Morton CL , Wadkins RM , Danks MK , Potter PM
Ref : Cancer Research , 59 :1458 , 1999
PubMedID: 10197614

Title : Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme - Potter_1998_Cancer.Res_58_3627
Author(s) : Potter PM , Wolverton JS , Morton CL , Wierdl M , Danks MK
Ref : Cancer Research , 58 :3627 , 1998
PubMedID: 9721871

Title : Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11 - Danks_1998_Cancer.Res_58_20
Author(s) : Danks MK , Morton CL , Pawlik CA , Potter PM
Ref : Cancer Research , 58 :20 , 1998
PubMedID: 9426050
Gene_locus related to this paper: rabit-1cxes

Title : Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11) - Potter_1998_Cancer.Res_58_2646
Author(s) : Potter PM , Pawlik CA , Morton CL , Naeve CW , Danks MK
Ref : Cancer Research , 58 :2646 , 1998
PubMedID: 9635592
Gene_locus related to this paper: rabit-1cxes

Title : In situ subcellular localization of epitope-tagged human and rabbit carboxylesterases - Potter_1998_Cytometry_32_223
Author(s) : Potter PM , Wolverton JS , Morton CL , Whipple DO , Danks MK
Ref : Cytometry , 32 :223 , 1998
PubMedID: 9667512

Title : Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase - Guichard_1998_Clin.Cancer.Res_4_3089
Author(s) : Guichard SM , Morton CL , Krull EJ , Stewart CF , Danks MK , Potter PM
Ref : Clin Cancer Research , 4 :3089 , 1998
PubMedID: 9865925