Morton CL

References (33)

Title : An improved human carboxylesterase for enzyme\/prodrug therapy with CPT-11 - Wierdl_2008_Cancer.Gene.Ther_15_183
Author(s) : Wierdl M , Tsurkan L , Hyatt JL , Edwards CC , Hatfield MJ , Morton CL , Houghton PJ , Danks MK , Redinbo MR , Potter PM
Ref : Cancer Gene Therapy , 15 :183 , 2008
PubMedID: 18188187

Title : Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 - Bencharit_2006_J.Mol.Biol_363_201
Author(s) : Bencharit S , Edwards CC , Morton CL , Howard-Williams EL , Kuhn P , Potter PM , Redinbo MR
Ref : Journal of Molecular Biology , 363 :201 , 2006
PubMedID: 16962139
Gene_locus related to this paper: human-CES1

Title : The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase - Harel_2005_Chem.Biol.Interact_157-158_153
Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Wadkins RM , Silman I , Sussman JL , Potter PM
Ref : Chemico-Biological Interactions , 157-158 :153 , 2005
PubMedID: 16289500
Gene_locus related to this paper: torca-ACHE

Title : The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action - Harel_2005_Mol.Pharmacol_67_1874
Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Yoon KJ , Wadkins RM , Silman I , Sussman JL , Potter PM
Ref : Molecular Pharmacology , 67 :1874 , 2005
PubMedID: 15772291
Gene_locus related to this paper: torca-ACHE

Title : Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11 - Hyatt_2005_Chem.Biol.Interact_157-158_247
Author(s) : Hyatt JL , Tsurkan L , Morton CL , Yoon KJ , Harel M , Brumshtein B , Silman I , Sussman JL , Wadkins RM , Potter PM
Ref : Chemico-Biological Interactions , 157-158 :247 , 2005
PubMedID: 16257398

Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906
Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM
Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005
PubMedID: 15828829

Title : Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice - Morton_2005_Cancer.Chemother.Pharmacol_56_629
Author(s) : Morton CL , Iacono L , Hyatt JL , Taylor KR , Cheshire PJ , Houghton PJ , Danks MK , Stewart CF , Potter PM
Ref : Cancer Chemother Pharmacol , 56 :629 , 2005
PubMedID: 15918039

Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165
Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR
Ref : Journal of Molecular Biology , 352 :165 , 2005
PubMedID: 16081098
Gene_locus related to this paper: human-CES1

Title : Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application - Yoon_2004_Mol.Cancer.Ther_3_903
Author(s) : Yoon KJ , Hyatt JL , Morton CL , Lee RE , Potter PM , Danks MK
Ref : Mol Cancer Ther , 3 :903 , 2004
PubMedID: 15299073

Title : Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity - Wadkins_2004_Mol.Pharmacol_65_1336
Author(s) : Wadkins RM , Hyatt JL , Yoon KJ , Morton CL , Lee RE , Damodaran K , Beroza P , Danks MK , Potter PM
Ref : Molecular Pharmacology , 65 :1336 , 2004
PubMedID: 15155827

Title : Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model - Wierdl_2004_Biochemistry_43_1874
Author(s) : Wierdl M , Morton CL , Nguyen NK , Redinbo MR , Potter PM
Ref : Biochemistry , 43 :1874 , 2004
PubMedID: 14967028

Title : Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies - Yoon_2003_Mol.Cancer.Ther_2_1171
Author(s) : Yoon KJ , Krull EJ , Morton CL , Bornmann WG , Lee RE , Potter PM , Danks MK
Ref : Mol Cancer Ther , 2 :1171 , 2003
PubMedID: 14617791

Title : Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism - Yoon_2003_Bioorg.Med.Chem_11_3237
Author(s) : Yoon KJ , Morton CL , Potter PM , Danks MK , Lee RE
Ref : Bioorganic & Medicinal Chemistry , 11 :3237 , 2003
PubMedID: 12837533

Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341
Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR
Ref : Chemical Biology , 10 :341 , 2003
PubMedID: 12725862
Gene_locus related to this paper: human-CES1

Title : Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme - Bencharit_2003_Nat.Struct.Biol_10_349
Author(s) : Bencharit S , Morton CL , Xue Y , Potter PM , Redinbo MR
Ref : Nat Struct Biol , 10 :349 , 2003
PubMedID: 12679808
Gene_locus related to this paper: human-CES1

Title : p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) - Wierdl_2003_J.Pharmacol.Exp.Ther_304_699
Author(s) : Wierdl M , Morton CL , Harris LC , Danks MK , Schuetz JD , Potter PM
Ref : Journal of Pharmacology & Experimental Therapeutics , 304 :699 , 2003
PubMedID: 12538824

Title : Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance - Wierdl_2003_Mol.Pharmacol_64_279
Author(s) : Wierdl M , Wall A , Morton CL , Sampath J , Danks MK , Schuetz JD , Potter PM
Ref : Molecular Pharmacology , 64 :279 , 2003
PubMedID: 12869632

Title : Structural insights into CPT-11 activation by mammalian carboxylesterases - Bencharit_2002_Nat.Struct.Biol_9_337
Author(s) : Bencharit S , Morton CL , Howard-Williams EL , Danks MK , Potter PM , Redinbo MR
Ref : Nat Struct Biol , 9 :337 , 2002
PubMedID: 11967565
Gene_locus related to this paper: rabit-1cxes

Title : Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients - Wagner_2002_Cancer.Res_62_5001
Author(s) : Wagner LM , Guichard SM , Burger RA , Morton CL , Straign CM , Ashmun RA , Harris LC , Houghton PJ , Potter PM , Danks MK
Ref : Cancer Research , 62 :5001 , 2002
PubMedID: 12208753

Title : Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases - Wadkins_2001_Mol.Pharmacol_60_355
Author(s) : Wadkins RM , Morton CL , Weeks JK , Oliver L , Wierdl M , Danks MK , Potter PM
Ref : Molecular Pharmacology , 60 :355 , 2001
PubMedID: 11455023

Title : Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase - Wierdl_2001_Cancer.Res_61_5078
Author(s) : Wierdl M , Morton CL , Weeks JK , Danks MK , Harris LC , Potter PM
Ref : Cancer Research , 61 :5078 , 2001
PubMedID: 11431344

Title : Construction of adenovirus for high level expression of small RNAs in mammalian cells. Application to a Bcl-2 ribozyme - Potter_2000_Mol.Biotechnol_15_105
Author(s) : Potter PM , McKenzie PP , Hussain N , Noonberg S , Morton CL , Harris LC
Ref : Mol Biotechnol , 15 :105 , 2000
PubMedID: 10949823

Title : Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase - Morton_2000_Mol.Biotechnol_16_193
Author(s) : Morton CL , Potter PM
Ref : Mol Biotechnol , 16 :193 , 2000
PubMedID: 11252804

Title : Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase - Morton_2000_Cancer.Res_60_4206
Author(s) : Morton CL , Wierdl M , Oliver L , Ma MK , Danks MK , Stewart CF , Eiseman JL , Potter PM
Ref : Cancer Research , 60 :4206 , 2000
PubMedID: 10945631

Title : Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation - Wierdl_2000_Biochem.Pharmacol_59_773
Author(s) : Wierdl M , Morton CL , Danks MK , Potter PM
Ref : Biochemical Pharmacology , 59 :773 , 2000
PubMedID: 10718335
Gene_locus related to this paper: horse-BCHE

Title : Proficient metabolism of irinotecan by a human intestinal carboxylesterase - Khanna_2000_Cancer.Res_60_4725
Author(s) : Khanna R , Morton CL , Danks MK , Potter PM
Ref : Cancer Research , 60 :4725 , 2000
PubMedID: 10987276

Title : Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme\/prodrug therapy - Danks_1999_Clin.Cancer.Res_5_917
Author(s) : Danks MK , Morton CL , Krull EJ , Cheshire PJ , Richmond LB , Naeve CW , Pawlik CA , Houghton PJ , Potter PM
Ref : Clin Cancer Research , 5 :917 , 1999
PubMedID: 10213229

Title : The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase - Morton_1999_Cancer.Res_59_1458
Author(s) : Morton CL , Wadkins RM , Danks MK , Potter PM
Ref : Cancer Research , 59 :1458 , 1999
PubMedID: 10197614

Title : Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme - Potter_1998_Cancer.Res_58_3627
Author(s) : Potter PM , Wolverton JS , Morton CL , Wierdl M , Danks MK
Ref : Cancer Research , 58 :3627 , 1998
PubMedID: 9721871

Title : Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11 - Danks_1998_Cancer.Res_58_20
Author(s) : Danks MK , Morton CL , Pawlik CA , Potter PM
Ref : Cancer Research , 58 :20 , 1998
PubMedID: 9426050
Gene_locus related to this paper: rabit-1cxes

Title : Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11) - Potter_1998_Cancer.Res_58_2646
Author(s) : Potter PM , Pawlik CA , Morton CL , Naeve CW , Danks MK
Ref : Cancer Research , 58 :2646 , 1998
PubMedID: 9635592
Gene_locus related to this paper: rabit-1cxes

Title : In situ subcellular localization of epitope-tagged human and rabbit carboxylesterases - Potter_1998_Cytometry_32_223
Author(s) : Potter PM , Wolverton JS , Morton CL , Whipple DO , Danks MK
Ref : Cytometry , 32 :223 , 1998
PubMedID: 9667512

Title : Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase - Guichard_1998_Clin.Cancer.Res_4_3089
Author(s) : Guichard SM , Morton CL , Krull EJ , Stewart CF , Danks MK , Potter PM
Ref : Clin Cancer Research , 4 :3089 , 1998
PubMedID: 9865925