Lenz DE

General

Full name : Lenz David E

First name : David E

Mail : USAMRICD\; 3100 Ricketts Point Rd\; Aberdeen Proving Ground\; MD 21010

Zip Code :

City :

Country : USA

Email : lenz@asia.apgea.army.mil

Phone : 410-436-2372

Fax : 410-436-1960

Website :

Directory :

References (43)

Title : Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication - Cerasoli_2019_Biochem.Pharmacol__113670
Author(s) : Cerasoli DM , Armstrong SJ , Reeves TE , Hodgins SM , Kasten SA , Lee-Stubbs RB , Cadieux CL , Otto TC , Capacio BR , Lenz DE
Ref : Biochemical Pharmacology , :113670 , 2019
PubMedID: 31628910

Title : Radiolabelled soman binding to sera from Rats, Guinea Pigs and Monkeys - Lenz_2017_Toxicol.Lett_283_86
Author(s) : Lenz DE , Cerasoli DM , Maxwell DM
Ref : Toxicol Lett , 283 :86 , 2017
PubMedID: 29155040

Title : Human butyrylcholinesterase efficacy against nerve agent exposure - Reed_2017_J.Biochem.Mol.Toxicol_31_
Author(s) : Reed BA , Sabourin CL , Lenz DE
Ref : J Biochem Mol Toxicol , 31 : , 2017
PubMedID: 28225154

Title : Solubilization and humanization of paraoxonase-1 - Sarkar_2012_J.Lipids_2012_610937
Author(s) : Sarkar M , Harsch CK , Matic GT , Hoffman K , Norris JR, 3rd , Otto TC , Lenz DE , Cerasoli DM , Magliery TJ
Ref : J Lipids , 2012 :610937 , 2012
PubMedID: 22720164

Title : Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs - Mumford_2011_Clin.Toxicol.(Phila)_49_287
Author(s) : Rice H , M EP , Lenz DE , Cerasoli DM
Ref : Clinical Toxicology (Phila) , 49 :287 , 2011
PubMedID: 21563904

Title : Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation - Cadieux_2010_Chem.Biol.Interact_187_229
Author(s) : Cadieux CL , Broomfield CA , Kirkpatrick MG , Kazanski ME , Lenz DE , Cerasoli DM
Ref : Chemico-Biological Interactions , 187 :229 , 2010
PubMedID: 20433814
Gene_locus related to this paper: cavpo-d3ye96

Title : Butyrylcholinesterase as a Therapeutic Drug for Protection against Percutaneous VX - Lenz_2010_Chem.Biol.Interact_187_249
Author(s) : Lenz DE , Clarkson ED , Schulz SM , Cerasoli DM
Ref : Chemico-Biological Interactions , 187 :249 , 2010
PubMedID: 20513442

Title : Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents - Geyer_2010_Proc.Natl.Acad.Sci.U.S.A_107_20251
Author(s) : Geyer BC , Kannan L , Garnaud PE , Broomfield CA , Cadieux CL , Cherni I , Hodgins SM , Kasten SA , Kelley K , Kilbourne J , Oliver ZP , Otto TC , Puffenberger I , Reeves TE , Robbins N, 2nd , Woods RR , Soreq H , Lenz DE , Cerasoli DM , Mor TS
Ref : Proc Natl Acad Sci U S A , 107 :20251 , 2010
PubMedID: 21059932

Title : Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae - Otto_2010_Chem.Biol.Interact_187_388
Author(s) : Otto TC , Kasten SA , Kovaleva E , Liu Z , Buchman G , Tolosa M , Davis D , Smith JR , Balcerzak R , Lenz DE , Cerasoli DM
Ref : Chemico-Biological Interactions , 187 :388 , 2010
PubMedID: 20176005

Title : Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights - Sanan_2010_J.Phys.Org.Chem_23_357
Author(s) : Sanan TT , Muthukrishnan S , Beck JM , Tao P , Hayes CJ , Otto TC , Cerasoli DM , Lenz DE , Hadad CM
Ref : J Phys Org Chem , 23 :357 , 2010
PubMedID: 24077808

Title : Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure - Haigh_2010_Chem.Biol.Interact_187_416
Author(s) : Haigh JR , Adler M , Apland JP , Deshpande SS , Barham CB , Desmond P , Koplovitz I , Lenz DE , Gordon RK
Ref : Chemico-Biological Interactions , 187 :416 , 2010
PubMedID: 20144889

Title : Engineering human PON1 in an E. coli expression system - Suzuki_2010_Adv.Exp.Med.Biol_660_37
Author(s) : Suzuki SM , Stevens RC , Richter RJ , Cole TB , Park S , Otto TC , Cerasoli DM , Lenz DE , Furlong CE
Ref : Advances in Experimental Medicine & Biology , 660 :37 , 2010
PubMedID: 20221869

Title : Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig - Mumford_2010_Chem.Biol.Interact_187_304
Author(s) : Mumford H , Price ME , Cerasoli DM , Teschner W , Ehrlich H , Schwarz HP , Lenz DE
Ref : Chemico-Biological Interactions , 187 :304 , 2010
PubMedID: 20176007

Title : In silico analyses of substrate interactions with human serum paraoxonase 1 - Hu_2009_Proteins_75_486
Author(s) : Hu X , Jiang X , Lenz DE , Cerasoli DM , Wallqvist A
Ref : Proteins , 75 :486 , 2009
PubMedID: 18951406

Title : DNA aptamers developed against a soman derivative cross-react with the methylphosphonic acid core but not with flanking hydrophobic groups - Bruno_2009_J.Mol.Recognit_22_197
Author(s) : Bruno JG , Carrillo MP , Cadieux CL , Lenz DE , Cerasoli DM , Phillips T
Ref : J Mol Recognit , 22 :197 , 2009
PubMedID: 19051203

Title : Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes - Otto_2009_Biochemistry_48_10416
Author(s) : Otto TC , Harsch CK , Yeung DT , Magliery TJ , Cerasoli DM , Lenz DE
Ref : Biochemistry , 48 :10416 , 2009
PubMedID: 19764813

Title : Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin - Huang_2008_BMC.Biotechnol_8_50
Author(s) : Huang YJ , Lundy PM , Lazaris A , Huang Y , Baldassarre H , Wang B , Turcotte C , Cote M , Bellemare A , Bilodeau AS , Brouillard S , Touati M , Herskovits P , Begin I , Neveu N , Brochu E , Pierson J , Hockley DK , Cerasoli DM , Lenz DE , Wilgus H , Karatzas CN , Langermann S
Ref : BMC Biotechnol , 8 :50 , 2008
PubMedID: 18485214

Title : Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys - Sun_2008_Chem.Biol.Interact_175_428
Author(s) : Sun W , Doctor BP , Lenz DE , Saxena A
Ref : Chemico-Biological Interactions , 175 :428 , 2008
PubMedID: 18674756

Title : A gas chromatographic-mass spectrometric approach to examining stereoselective interaction of human plasma proteins with soman - Yeung_2008_J.Anal.Toxicol_32_86
Author(s) : Yeung DT , Smith JR , Sweeney RE , Lenz DE , Cerasoli DM
Ref : J Anal Toxicol , 32 :86 , 2008
PubMedID: 18269799

Title : A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters - Masson_2008_Chem.Biol.Interact_175_273
Author(s) : Masson P , Nachon F , Broomfield CA , Lenz DE , Verdier L , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , 175 :273 , 2008
PubMedID: 18508040

Title : Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning - Huang_2007_Proc.Natl.Acad.Sci.U.S.A_104_13603
Author(s) : Huang YJ , Huang Y , Baldassarre H , Wang B , Lazaris A , Leduc M , Bilodeau AS , Bellemare A , Cote M , Herskovits P , Touati M , Turcotte C , Valeanu L , Lemee N , Wilgus H , Begin I , Bhatia B , Rao K , Neveu N , Brochu E , Pierson J , Hockley DK , Cerasoli DM , Lenz DE , Karatzas CN , Langermann S
Ref : Proc Natl Acad Sci U S A , 104 :13603 , 2007
PubMedID: 17660298

Title : Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review - Lenz_2007_Toxicology_233_31
Author(s) : Lenz DE , Yeung D , Smith JR , Sweeney RE , Lumley LA , Cerasoli DM
Ref : Toxicology , 233 :31 , 2007
PubMedID: 17188793

Title : Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase - Yeung_2007_FEBS.J_274_1183
Author(s) : Yeung DT , Smith JR , Sweeney RE , Lenz DE , Cerasoli DM
Ref : Febs J , 274 :1183 , 2007
PubMedID: 17286579

Title : Bioscavenger for protection from toxicity of organophosphorus compounds - Saxena_2006_J.Mol.Neurosci_30_145
Author(s) : Saxena A , Sun W , Luo C , Myers TM , Koplovitz I , Lenz DE , Doctor BP
Ref : Journal of Molecular Neuroscience , 30 :145 , 2006
PubMedID: 17192662

Title : In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger - Cerasoli_2005_Chem.Biol.Interact_157-158_363
Author(s) : Cerasoli DM , Griffiths EM , Doctor BP , Saxena A , Fedorko JM , Greig NH , Yu QS , Huang Y , Wilgus H , Karatzas CN , Koplovitz I , Lenz DE
Ref : Chemico-Biological Interactions , 157-158 :363 , 2005
PubMedID: 16429486

Title : Role of immunogen design in induction of soman-specific monoclonal antibodies - Johnson_2005_Immunol.Lett_96_121
Author(s) : Johnson JK , Cerasoli DM , Lenz DE
Ref : Immunol Lett , 96 :121 , 2005
PubMedID: 15585315

Title : Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys - Lenz_2005_Chem.Biol.Interact_157-158_205
Author(s) : Lenz DE , Maxwell DM , Koplovitz I , Clark CR , Capacio BR , Cerasoli DM , Federko JM , Luo C , Saxena A , Doctor BP , Olson C
Ref : Chemico-Biological Interactions , 157-158 :205 , 2005
PubMedID: 16289064

Title : Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates - Yeung_2005_FEBS.J_272_2225
Author(s) : Yeung DT , Lenz DE , Cerasoli DM
Ref : Febs J , 272 :2225 , 2005
PubMedID: 15853807

Title : Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman - Gordon_2005_Chem.Biol.Interact_157-158_239
Author(s) : Gordon RK , Haigh JR , Garcia GE , Feaster SR , Riel MA , Lenz DE , Aisen PS , Doctor BP
Ref : Chemico-Biological Interactions , 157-158 :239 , 2005
PubMedID: 16256090

Title : Structure\/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model - Yeung_2004_Biochim.Biophys.Acta_1702_67
Author(s) : Yeung DT , Josse D , Nicholson JD , Khanal A , McAndrew CW , Bahnson BJ , Lenz DE , Cerasoli DM
Ref : Biochimica & Biophysica Acta , 1702 :67 , 2004
PubMedID: 15450851

Title : Protective action of the serine protease inhibitor N-tosyl-L-lysine chloromethyl ketone (TLCK) against acute soman poisoning - Cowan_2001_J.Appl.Toxicol_21_293
Author(s) : Cowan FM , Broomfield CA , Lenz DE , Shih TM
Ref : J Appl Toxicol , 21 :293 , 2001
PubMedID: 11481662

Title : Development of an immunoassay for diagnosis of exposure to toxic organophosphorus compounds - Miller_2001_J.Appl.Toxicol_21 Suppl 1_S23
Author(s) : Miller JK , Lenz DE
Ref : J Appl Toxicol , 21 Suppl 1 :S23 , 2001
PubMedID: 11920916

Title : Organophosphate skin decontamination using immobilized enzymes - Gordon_1999_Chem.Biol.Interact_119-120_463
Author(s) : Gordon RK , Feaster SR , Russell AJ , LeJeune KE , Maxwell DM , Lenz DE , Ross M , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :463 , 1999
PubMedID: 10421484

Title : Characterization of ChEs Immobilized on Polyurethane Foams -
Author(s) : Gordon RK , Feaster SR , Herron PC II , Lowe ER , LeJeune KE , Russell AJ , Lenz DE , Ross M , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :307 , 1998
PubMedID:

Title : Behavioral decrements persist in rhesus monkeys trained on a serial probe recognition task despite protection against soman lethality by butyrylcholinesterase - Castro_1994_Neurotoxicol.Teratol_16_145
Author(s) : Castro CA , Gresham VC , Finger AV , Maxwell DM , Solana RP , Lenz DE , Broomfield CA
Ref : Neurotoxicology & Teratology , 16 :145 , 1994
PubMedID: 8052188

Title : The role of glutamate-199 in the aging of cholinesterase - Saxena_1993_Biochem.Biophys.Res.Commun_197_343
Author(s) : Saxena A , Doctor BP , Maxwell DM , Lenz DE , Radic Z , Taylor P
Ref : Biochemical & Biophysical Research Communications , 197 :343 , 1993
PubMedID: 7902714

Title : Catalytic antibodies hydrolysing organophosphorus esters - Brimfield_1993_Chem.Biol.Interact_87_95
Author(s) : Brimfield AA , Lenz DE , Maxwell DM , Broomfield CA
Ref : Chemico-Biological Interactions , 87 :95 , 1993
PubMedID: 8344006

Title : Poster: Protection by butyry1cholinesterase against soman poisoning -
Author(s) : Lenz DE , Broomfield CA , Maxwell CA , Solana RP , Finger AV , Woodard CL
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :302 , 1991
PubMedID:

Title : Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates - Broomfield_1991_J.Pharmacol.Exp.Ther_259_633
Author(s) : Broomfield CA , Maxwell DM , Solana RP , Castro CA , Finger AV , Lenz DE
Ref : Journal of Pharmacology & Experimental Therapeutics , 259 :633 , 1991
PubMedID: 1941611

Title : Hepatic subcellular localization of cresylbenzodioxaphosphorin oxide (CBDP)-sensitive soman binding sites - Little_1990_Biochem.Pharmacol_40_1733
Author(s) : Little JS , Maxwell DM , Fox-Talbot MK , Brecht K , Lenz DE
Ref : Biochemical Pharmacology , 40 :1733 , 1990
PubMedID: 2242010

Title : Effect of carboxylesterase inhibition on carbamate protection against soman toxicity - Maxwell_1988_J.Pharmacol.Exp.Ther_246_986
Author(s) : Maxwell DM , Brecht KM , Lenz DE , O'Neill BL
Ref : Journal of Pharmacology & Experimental Therapeutics , 246 :986 , 1988
PubMedID: 3418520

Title : Structural and stereochemical specificity of mouse monoclonal antibodies to the organophosphorous cholinesterase inhibitor soman - Brimfield_1985_Mol.Pharmacol_28_32
Author(s) : Brimfield AA , Hunter KW, Jr. , Lenz DE , Benschop HP , van Dijk C , De Jong LP
Ref : Molecular Pharmacology , 28 :32 , 1985
PubMedID: 4021995

Title : Inhibition of rat cerebrum acetylcholinesterase isoenzymes after acute administration of soman -
Author(s) : Lenz DE , Maxwell DM
Ref : Biochemical Pharmacology , 30 :1369 , 1981
PubMedID: 7271832