Scharpe S

References (46)

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Title : Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors - Matheeussen_2012_Clin.Chim.Acta_413_456
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Title : Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries - Matheeussen_2011_Biol.Chem_392_189
Author(s) : Matheeussen V , Baerts L , De Meyer G , De Keulenaer G , Van der Veken P , Augustyns K , Dubois V , Scharpe S , De Meester I
Ref : Biol Chem , 392 :189 , 2011
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Title : Dipeptidyl peptidase 9 (DPP9) from bovine testes: identification and characterization as the short form by mass spectrometry - Dubois_2010_Biochim.Biophys.Acta_1804_781
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Title : Dipeptidyl peptidases and related proteins: multifaceted markers and therapeutic targets -
Author(s) : De Meester I , Scharpe S , Lambeir AM
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Title : Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues - Dubois_2009_J.Histochem.Cytochem_57_531
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PubMedID: 19188489
Gene_locus related to this paper: rat-dpp9

Title : In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma - Jost_2009_Biochem.Pharmacol_77_228
Author(s) : Jost MM , Lamerz J , Tammen H , Menzel C , De Meester I , Lambeir AM , Augustyns K , Scharpe S , Zucht HD , Rose H , Jurgens M , Schulz-Knappe P , Budde P
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PubMedID: 18940185

Title : Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside - Vanderheyden_2009_Clin.Chem.Lab.Med_47_248
Author(s) : Vanderheyden M , Bartunek J , Goethals M , Verstreken S , Lambeir AM , De Meester I , Scharpe S
Ref : Clinical Chemistry & Laboratory Medicine , 47 :248 , 2009
PubMedID: 19327104

Title : Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein - Brandt_2008_Peptides_29_1472
Author(s) : Brandt I , Gerard M , Sergeant K , Devreese B , Baekelandt V , Augustyns K , Scharpe S , Engelborghs Y , Lambeir AM
Ref : Peptides , 29 :1472 , 2008
PubMedID: 18571285

Title : Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes - Dubois_2008_Front.Biosci_13_3558
Author(s) : Dubois V , Lambeir AM , Van der Veken P , Augustyns K , Creemers J , Chen X , Scharpe S , De Meester I
Ref : Front Biosci , 13 :3558 , 2008
PubMedID: 18508455

Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors - Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159
Author(s) : Van Goethem S , Van der Veken P , Dubois V , Soroka A , Lambeir AM , Chen X , Haemers A , Scharpe S , De Meester I , Augustyns K
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4159 , 2008
PubMedID: 18556198

Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads - Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154
Author(s) : Van der Veken P , De Meester I , Dubois V , Soroka A , Van Goethem S , Maes MB , Brandt I , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4154 , 2008
PubMedID: 18556199

Title : DPP4 inhibitors for diabetes--what next? - Lambeir_2008_Biochem.Pharmacol_76_1637
Author(s) : Lambeir AM , Scharpe S , De Meester I
Ref : Biochemical Pharmacology , 76 :1637 , 2008
PubMedID: 18755155

Title : Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates - Van der Veken_2007_J.Med.Chem_50_5568
Author(s) : Van der Veken P , Soroka A , Brandt I , Chen YS , Maes MB , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K , De Meester I
Ref : Journal of Medicinal Chemistry , 50 :5568 , 2007
PubMedID: 17958345

Title : Dipeptidyl peptidase 8\/9-like activity in human leukocytes - Maes_2007_J.Leukoc.Biol_81_1252
Author(s) : Maes MB , Dubois V , Brandt I , Lambeir AM , Van der Veken P , Augustyns K , Cheng JD , Chen X , Scharpe S , De Meester I
Ref : J Leukoc Biol , 81 :1252 , 2007
PubMedID: 17287297

Title : Ischemia\/reperfusion injury: The role of CD26\/dipeptidyl-peptidase-IV-inhibition in lung transplantation - Zhai_2006_Transplant.Proc_38_3369
Author(s) : Zhai W , Cardell M , De Meester I , Augustyns K , Hillinger S , Inci I , Arni S , Jungraithmayr W , Scharpe S , Weder W , Korom S
Ref : Transplant Proc , 38 :3369 , 2006
PubMedID: 17175274

Title : Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form - Brandt_2006_Clin.Chem_52_82
Author(s) : Brandt I , Lambeir AM , Ketelslegers JM , Vanderheyden M , Scharpe S , De Meester I
Ref : Clinical Chemistry , 52 :82 , 2006
PubMedID: 16254193

Title : Dipeptidyl peptidase II and leukocyte cell death - Maes_2006_Biochem.Pharmacol_72_70
Author(s) : Maes MB , Martinet W , Schrijvers DM , Van der Veken P , De Meyer GR , Augustyns K , Lambeir AM , Scharpe S , De Meester I
Ref : Biochemical Pharmacology , 72 :70 , 2006
PubMedID: 16725115

Title : In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII -
Author(s) : Maes MB , Lambeir AM , Van der Veken P , De Winter B , Augustyns K , Scharpe S , De Meester I
Ref : Advances in Experimental Medicine & Biology , 575 :73 , 2006
PubMedID: 16700510

Title : Peptide substrates of dipeptidyl peptidases -
Author(s) : Brandt I , Lambeir AM , Maes MB , Scharpe S , De Meester I
Ref : Advances in Experimental Medicine & Biology , 575 :3 , 2006
PubMedID: 16700503

Title : Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines - Soroka_2006_Bioorg.Med.Chem.Lett_16_4777
Author(s) : Soroka A , Van der Veken P , De Meester I , Lambeir AM , Maes MB , Scharpe S , Haemers A , Augustyns K
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :4777 , 2006
PubMedID: 16844373

Title : Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile) - Brandt_2005_Biochem.Pharmacol_70_134
Author(s) : Brandt I , Joossens J , Chen X , Maes MB , Scharpe S , De Meester I , Lambeir AM
Ref : Biochemical Pharmacology , 70 :134 , 2005
PubMedID: 15907807

Title : Search for substrates for prolyl oligopeptidase in porcine brain - Brandt_2005_Peptides_26_2536
Author(s) : Brandt I , De Vriendt K , Devreese B , Van Beeumen J , Van Dongen W , Augustyns K , De Meester I , Scharpe S , Lambeir AM
Ref : Peptides , 26 :2536 , 2005
PubMedID: 15996789

Title : Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases - Van der Veken_2005_J.Med.Chem_48_1768
Author(s) : Van der Veken P , Senten K , Kertesz I , De Meester I , Lambeir AM , Maes MB , Scharpe S , Haemers A , Augustyns K
Ref : Journal of Medicinal Chemistry , 48 :1768 , 2005
PubMedID: 15771423

Title : Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)\/dipeptidyl peptidase 7 (DPP7) - Maes_2005_Biochem.J_386_315
Author(s) : Maes MB , Lambeir AM , Gilany K , Senten K , Van der Veken P , Leiting B , Augustyns K , Scharpe S , De Meester I
Ref : Biochemical Journal , 386 :315 , 2005
PubMedID: 15487984
Gene_locus related to this paper: human-DPP7

Title : Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis - Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871
Author(s) : Rea D , Lambeir AM , Kumagai Y , De Meester I , Scharpe S , Fulop V
Ref : Acta Crystallographica D Biol Crystallogr , 60 :1871 , 2004
PubMedID: 15388936
Gene_locus related to this paper: porgi-DPP

Title : Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors - Senten_2004_J.Med.Chem_47_2906
Author(s) : Senten K , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K
Ref : Journal of Medicinal Chemistry , 47 :2906 , 2004
PubMedID: 15139769

Title : Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV -
Author(s) : De Meester I , Lambeir AM , Proost P , Scharpe S
Ref : Advances in Experimental Medicine & Biology , 524 :3 , 2003
PubMedID: 12675218

Title : Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases - Senten_2003_J.Med.Chem_46_5005
Author(s) : Senten K , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K
Ref : Journal of Medicinal Chemistry , 46 :5005 , 2003
PubMedID: 14584950

Title : Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV - Lambeir_2003_Crit.Rev.Clin.Lab.Sci_40_209
Author(s) : Lambeir AM , Durinx C , Scharpe S , De Meester I
Ref : Crit Rev Clin Lab Sci , 40 :209 , 2003
PubMedID: 12892317

Title : Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis. Comparison with the human enzyme -
Author(s) : Lambeir AM , Rea D , Fulop V , Kumagai Y , Augustyns K , De Meester I , Haemers A , Scharpe S
Ref : Advances in Experimental Medicine & Biology , 524 :29 , 2003
PubMedID: 12675220

Title : Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases - Senten_2003_J.Comb.Chem_5_336
Author(s) : Senten K , Daniels L , Van der Veken P , De Meester I , Lambeir AM , Scharpe S , Haemers A , Augustyns K
Ref : J Comb Chem , 5 :336 , 2003
PubMedID: 12739951

Title : Presence and release of SR-17 (chromogranin B(586-602)) in the porcine splenic nerve and its enzymatic degradation by CD26\/dipeptidyl peptidase IV - Depreitere_2002_Regul.Pept_106_71
Author(s) : Depreitere J , Durinx C , Wang Z , Coen E , Lambeir AM , Scharpe S , De Potter W , Nouwen EJ
Ref : Regul Pept , 106 :71 , 2002
PubMedID: 12047913

Title : Kinetic investigation of chemokine truncation by CD26\/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family - Lambeir_2001_J.Biol.Chem_276_29839
Author(s) : Lambeir AM , Proost P , Durinx C , Bal G , Senten K , Augustyns K , Scharpe S , Van Damme J , De Meester I
Ref : Journal of Biological Chemistry , 276 :29839 , 2001
PubMedID: 11390394

Title : Kinetic study of the processing by dipeptidyl-peptidase IV\/CD26 of neuropeptides involved in pancreatic insulin secretion - Lambeir_2001_FEBS.Lett_507_327
Author(s) : Lambeir AM , Durinx C , Proost P , Van Damme J , Scharpe S , De Meester I
Ref : FEBS Letters , 507 :327 , 2001
PubMedID: 11696365

Title : Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26\/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides - Durinx_2000_Eur.J.Biochem_267_5608
Author(s) : Durinx C , Lambeir AM , Bosmans E , Falmagne JB , Berghmans R , Haemers A , Scharpe S , De Meester I
Ref : European Journal of Biochemistry , 267 :5608 , 2000
PubMedID: 10951221

Title : Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors - Belyaev_1999_J.Med.Chem_42_1041
Author(s) : Belyaev A , Zhang X , Augustyns K , Lambeir AM , De Meester I , Vedernikova I , Scharpe S , Haemers A
Ref : Journal of Medicinal Chemistry , 42 :1041 , 1999
PubMedID: 10090787

Title : Development and evaluation of peptide-based prolyl oligopeptidase inhibitors--introduction of N-benzyloxycarbonyl-prolyl-3- fluoropyrrolidine as a lead in inhibitor design - Goossens_1997_Eur.J.Biochem_250_177
Author(s) : Goossens F , Vanhoof G , De Meester I , Augustyns K , Borloo M , Tourwe D , Haemers A , Scharpe S
Ref : European Journal of Biochemistry , 250 :177 , 1997
PubMedID: 9432007

Title : In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-diphenyl-phosphonate (Prodipine) - De Meester_1997_Biochem.Pharmacol_54_173
Author(s) : De Meester I , Belyaev A , Lambeir AM , De Meyer GR , Van Osselaer N , Haemers A , Scharpe S
Ref : Biochemical Pharmacology , 54 :173 , 1997
PubMedID: 9296364

Title : A prediction of DPP IV\/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma - Lambeir_1997_Biochim.Biophys.Acta_1340_215
Author(s) : Lambeir AM , Diaz Pereira JF , Chacon P , Vermeulen G , Heremans K , Devreese B , Van Beeumen J , De Meester I , Scharpe S
Ref : Biochimica & Biophysica Acta , 1340 :215 , 1997
PubMedID: 9252108

Title : Use of immobilized adenosine deaminase (EC 3.5.4.4) for the rapid purification of native human CD26\/dipeptidyl peptidase IV (EC 3.4.14.5) - de Meester_1996_J.Immunol.Methods_189_99
Author(s) : De Meester I , Vanhoof G , Lambeir AM , Scharpe S
Ref : Journal of Immunological Methodsods , 189 :99 , 1996
PubMedID: 8576585

Title : Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV - Lambeir_1996_Biochim.Biophys.Acta_1290_76
Author(s) : Lambeir AM , Borloo M , De Meester I , Belyaev A , Augustyns K , Hendriks D , Scharpe S , Haemers A
Ref : Biochimica & Biophysica Acta , 1290 :76 , 1996
PubMedID: 8645710

Title : The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha\/beta hydrolase fold family - Goossens_1995_Eur.J.Biochem_233_432
Author(s) : Goossens F , De Meester I , Vanhoof G , Hendriks D , Vriend G , Scharpe S
Ref : European Journal of Biochemistry , 233 :432 , 1995
PubMedID: 7588785
Gene_locus related to this paper: human-PREP

Title : Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase - Vanhoof_1994_Gene_149_363
Author(s) : Vanhoof G , Goossens F , Hendriks L , De Meester I , Hendriks D , Vriend G , Van Broeckhoven C , Scharpe S
Ref : Gene , 149 :363 , 1994
PubMedID: 7959018
Gene_locus related to this paper: human-PREP

Title : Purified and cell-bound CD26: enzymatic inhibition, antibody binding profile, and expression on T cells in relation to other surface markers - Scharpe_1994_Verh.K.Acad.Geneeskd.Belg_56_537
Author(s) : Scharpe S , De Meester I
Ref : Verh K Acad Geneeskd Belg , 56 :537 , 1994
PubMedID: 7892748

Title : Molecular characterization of an extracellular acid-resistant lipase produced by Rhizopus javanicus - Uyttenbroeck_1993_Biol.Chem.Hoppe.Seyler_374_245
Author(s) : Uyttenbroeck W , Hendriks D , Vriend G , De Baere I , Moens L , Scharpe S
Ref : Biol Chem Hoppe Seyler , 374 :245 , 1993
PubMedID: 8329142