Hansen C

References (2)

Title : Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14 - Gardner_2002_Nature_419_531
Author(s) : Gardner MJ , Shallom SJ , Carlton JM , Salzberg SL , Nene V , Shoaibi A , Ciecko A , Lynn J , Rizzo M , Weaver B , Jarrahi B , Brenner M , Parvizi B , Tallon L , Moazzez A , Granger D , Fujii C , Hansen C , Pederson J , Feldblyum T , Peterson J , Suh B , Angiuoli S , Pertea M , Allen J , Selengut J , White O , Cummings LM , Smith HO , Adams MD , Venter JC , Carucci DJ , Hoffman SL , Fraser CM
Ref : Nature , 419 :531 , 2002
Abstract : The mosquito-borne malaria parasite Plasmodium falciparum kills an estimated 0.7-2.7 million people every year, primarily children in sub-Saharan Africa. Without effective interventions, a variety of factors-including the spread of parasites resistant to antimalarial drugs and the increasing insecticide resistance of mosquitoes-may cause the number of malaria cases to double over the next two decades. To stimulate basic research and facilitate the development of new drugs and vaccines, the genome of Plasmodium falciparum clone 3D7 has been sequenced using a chromosome-by-chromosome shotgun strategy. We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome.
ESTHER : Gardner_2002_Nature_419_531
PubMedSearch : Gardner_2002_Nature_419_531
PubMedID: 12368868
Gene_locus related to this paper: plafa-MAL3P8.11

Title : Normal and defective expression of the thyroglobulin gene - Vassart_1987_Horm.Res_26_8
Author(s) : Vassart G , Brocas H , Christophe D , de Martynoff G , Gerard C , Hansen C , Juvenal G , Ludgate M , Mercken L , Parma J , et al.
Ref : Horm Res , 26 :8 , 1987
Abstract : Molecular studies of the thyroglobulin (Tg) gene have progressed significantly in recent years. Cloning and sequencing the complete bovine Tg cDNA led to the knowledge of the primary structure of the Tg subunit. This large polypeptidic chain displays a repetitive structure, especially in its amino-terminal half, and bears a striking homology with the acetylcholinesterase molecule of Torpedo californica in its carboxy-terminal portion. The four specific domains known to be involved in the formation of the thyroid hormones have been assigned to both terminal parts of the polypeptide, a location which could play a role in the process leading to hormone release. The very large (greater than 250 kb) Tg gene has been localized on the long arm of chromosome 8 in man, in close linkage with the c-myc oncogene. The study of its structure allowed the characterization of the molecular defect responsible for a congenital flaw in Tg gene expression in a herd of South-African cattle. This work led to the unexpected finding that the Tg pre-mRNA undergoes alternative splicing in normal animals, too. A DNA segment involved in the transcriptional control of Tg gene expression by cAMP has been identified by transfecting primary cultured thyrocytes with recombinant genes.
ESTHER : Vassart_1987_Horm.Res_26_8
PubMedSearch : Vassart_1987_Horm.Res_26_8
PubMedID: 3297966