Nene V

References (7)

Title : Comparative genomics of the neglected human malaria parasite Plasmodium vivax - Carlton_2008_Nature_455_757
Author(s) : Carlton JM , Adams JH , Silva JC , Bidwell SL , Lorenzi H , Caler E , Crabtree J , Angiuoli SV , Merino EF , Amedeo P , Cheng Q , Coulson RM , Crabb BS , Del Portillo HA , Essien K , Feldblyum TV , Fernandez-Becerra C , Gilson PR , Gueye AH , Guo X , Kang'a S , Kooij TW , Korsinczky M , Meyer EV , Nene V , Paulsen I , White O , Ralph SA , Ren Q , Sargeant TJ , Salzberg SL , Stoeckert CJ , Sullivan SA , Yamamoto MM , Hoffman SL , Wortman JR , Gardner MJ , Galinski MR , Barnwell JW , Fraser-Liggett CM
Ref : Nature , 455 :757 , 2008
Abstract : The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.
ESTHER : Carlton_2008_Nature_455_757
PubMedSearch : Carlton_2008_Nature_455_757
PubMedID: 18843361
Gene_locus related to this paper: plakh-b3lb44 , plavi-a5kcq0 , plavs-a5k2k6 , plavs-a5k3z4 , plavs-a5k4s6 , plavs-a5k5e4 , plavs-a5k7t5 , plavs-a5k686 , plavs-a5kaa1 , plavs-a5kaa3 , plavs-a5kas6 , plavs-a5kcm2

Title : Genome sequence of Aedes aegypti, a major arbovirus vector - Nene_2007_Science_316_1718
Author(s) : Nene V , Wortman JR , Lawson D , Haas B , Kodira C , Tu ZJ , Loftus B , Xi Z , Megy K , Grabherr M , Ren Q , Zdobnov EM , Lobo NF , Campbell KS , Brown SE , Bonaldo MF , Zhu J , Sinkins SP , Hogenkamp DG , Amedeo P , Arensburger P , Atkinson PW , Bidwell S , Biedler J , Birney E , Bruggner RV , Costas J , Coy MR , Crabtree J , Crawford M , Debruyn B , Decaprio D , Eiglmeier K , Eisenstadt E , El-Dorry H , Gelbart WM , Gomes SL , Hammond M , Hannick LI , Hogan JR , Holmes MH , Jaffe D , Johnston JS , Kennedy RC , Koo H , Kravitz S , Kriventseva EV , Kulp D , LaButti K , Lee E , Li S , Lovin DD , Mao C , Mauceli E , Menck CF , Miller JR , Montgomery P , Mori A , Nascimento AL , Naveira HF , Nusbaum C , O'Leary S , Orvis J , Pertea M , Quesneville H , Reidenbach KR , Rogers YH , Roth CW , Schneider JR , Schatz M , Shumway M , Stanke M , Stinson EO , Tubio JM , Vanzee JP , Verjovski-Almeida S , Werner D , White O , Wyder S , Zeng Q , Zhao Q , Zhao Y , Hill CA , Raikhel AS , Soares MB , Knudson DL , Lee NH , Galagan J , Salzberg SL , Paulsen IT , Dimopoulos G , Collins FH , Birren B , Fraser-Liggett CM , Severson DW
Ref : Science , 316 :1718 , 2007
Abstract : We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
ESTHER : Nene_2007_Science_316_1718
PubMedSearch : Nene_2007_Science_316_1718
PubMedID: 17510324
Gene_locus related to this paper: aedae-ACHE , aedae-ACHE1 , aedae-glita , aedae-q0iea6 , aedae-q0iev6 , aedae-q0ifn6 , aedae-q0ifn8 , aedae-q0ifn9 , aedae-q0ifp0 , aedae-q0ig41 , aedae-q1dgl0 , aedae-q1dh03 , aedae-q1dh19 , aedae-q1hqe6 , aedae-Q8ITU8 , aedae-Q8MMJ6 , aedae-Q8T9V6 , aedae-q16e91 , aedae-q16f04 , aedae-q16f25 , aedae-q16f26 , aedae-q16f28 , aedae-q16f29 , aedae-q16f30 , aedae-q16gq5 , aedae-q16iq5 , aedae-q16je0 , aedae-q16je1 , aedae-q16je2 , aedae-q16ks8 , aedae-q16lf2 , aedae-q16lv6 , aedae-q16m61 , aedae-q16mc1 , aedae-q16mc6 , aedae-q16mc7 , aedae-q16md1 , aedae-q16ms7 , aedae-q16nk5 , aedae-q16rl5 , aedae-q16rz9 , aedae-q16si8 , aedae-q16t49 , aedae-q16wf1 , aedae-q16x18 , aedae-q16xp8 , aedae-q16xu6 , aedae-q16xw5 , aedae-q16xw6 , aedae-q16y04 , aedae-q16y05 , aedae-q16y06 , aedae-q16y07 , aedae-q16y39 , aedae-q16y40 , aedae-q16yg4 , aedae-q16z03 , aedae-q17aa7 , aedae-q17av1 , aedae-q17av2 , aedae-q17av3 , aedae-q17av4 , aedae-q17b28 , aedae-q17b29 , aedae-q17b30 , aedae-q17b31 , aedae-q17b32 , aedae-q17bm3 , aedae-q17bm4 , aedae-q17bv7 , aedae-q17c44 , aedae-q17cz1 , aedae-q17d32 , aedae-q17g39 , aedae-q17g40 , aedae-q17g41 , aedae-q17g42 , aedae-q17g43 , aedae-q17g44 , aedae-q17gb8 , aedae-q17gr3 , aedae-q17if7 , aedae-q17if9 , aedae-q17ig1 , aedae-q17ig2 , aedae-q17is4 , aedae-q17l09 , aedae-q17m26 , aedae-q17mg9 , aedae-q17mv4 , aedae-q17mv5 , aedae-q17mv6 , aedae-q17mv7 , aedae-q17mw8 , aedae-q17mw9 , aedae-q17nw5 , aedae-q17nx5 , aedae-q17pa4 , aedae-q17q69 , aedae-q170k7 , aedae-q171y4 , aedae-q172e0 , aedae-q176i8 , aedae-q176j0 , aedae-q177k1 , aedae-q177k2 , aedae-q177l9 , aedae-j9hic3 , aedae-q179r9 , aedae-u483 , aedae-j9hj23 , aedae-q17d68 , aedae-q177c7 , aedae-q0ifp1 , aedae-a0a1s4fx83 , aedae-a0a1s4g2m0 , aedae-q1hr49

Title : Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes - Gardner_2005_Science_309_134
Author(s) : Gardner MJ , Bishop R , Shah T , de Villiers EP , Carlton JM , Hall N , Ren Q , Paulsen IT , Pain A , Berriman M , Wilson RJ , Sato S , Ralph SA , Mann DJ , Xiong Z , Shallom SJ , Weidman J , Jiang L , Lynn J , Weaver B , Shoaibi A , Domingo AR , Wasawo D , Crabtree J , Wortman JR , Haas B , Angiuoli SV , Creasy TH , Lu C , Suh B , Silva JC , Utterback TR , Feldblyum TV , Pertea M , Allen J , Nierman WC , Taracha EL , Salzberg SL , White OR , Fitzhugh HA , Morzaria S , Venter JC , Fraser CM , Nene V
Ref : Science , 309 :134 , 2005
Abstract : We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.
ESTHER : Gardner_2005_Science_309_134
PubMedSearch : Gardner_2005_Science_309_134
PubMedID: 15994558
Gene_locus related to this paper: thepa-q4mzr2 , thepa-q4n0b4 , thepa-q4n2i4 , thepa-q4n4i8 , thepa-q4n5d6 , thepa-q4n5m4 , thepa-q4n006 , thepa-q4n9g7 , thepa-q4n315 , thepa-q4n349 , thepa-q4n803

Title : BmiGI: a database of cDNAs expressed in Boophilus microplus, the tropical\/southern cattle tick - Guerrero_2005_Insect.Biochem.Mol.Biol_35_585
Author(s) : Guerrero FD , Miller RJ , Rousseau ME , Sunkara S , Quackenbush J , Lee Y , Nene V
Ref : Insect Biochemistry & Molecular Biology , 35 :585 , 2005
Abstract : We used an expressed sequence tag approach to initiate a study of the genome of the southern cattle tick, Boophilus microplus. A normalized cDNA library was synthesized from pooled RNA purified from tick larvae which had been subjected to different treatments, including acaricide exposure, heat shock, cold shock, host odor, and infection with Babesia bovis. For the acaricide exposure experiments, we used several strains of ticks, which varied in their levels of susceptibility to pyrethroid, organophosphate and amitraz. We also included RNA purified from samples of eggs, nymphs and adult ticks and dissected tick organs. Plasmid DNA was prepared from 11,520 cDNA clones and both 5' and 3' sequencing performed on each clone. The sequence data was used to search public protein databases and a B. microplus gene index was constructed, consisting of 8270 unique sequences whose associated putative functional assignments, when available, can be viewed at the TIGR website (http://www.tigr.org/tdb/tgi). A number of novel sequences were identified which possessed significant sequence similarity to genes, which might be involved in resistance to acaricides.
ESTHER : Guerrero_2005_Insect.Biochem.Mol.Biol_35_585
PubMedSearch : Guerrero_2005_Insect.Biochem.Mol.Biol_35_585
PubMedID: 15857764

Title : Genome of the host-cell transforming parasite Theileria annulata compared with T. parva - Pain_2005_Science_309_131
Author(s) : Pain A , Renauld H , Berriman M , Murphy L , Yeats CA , Weir W , Kerhornou A , Aslett M , Bishop R , Bouchier C , Cochet M , Coulson RM , Cronin A , de Villiers EP , Fraser A , Fosker N , Gardner M , Goble A , Griffiths-Jones S , Harris DE , Katzer F , Larke N , Lord A , Maser P , McKellar S , Mooney P , Morton F , Nene V , O'Neil S , Price C , Quail MA , Rabbinowitsch E , Rawlings ND , Rutter S , Saunders D , Seeger K , Shah T , Squares R , Squares S , Tivey A , Walker AR , Woodward J , Dobbelaere DA , Langsley G , Rajandream MA , McKeever D , Shiels B , Tait A , Barrell B , Hall N
Ref : Science , 309 :131 , 2005
Abstract : Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
ESTHER : Pain_2005_Science_309_131
PubMedSearch : Pain_2005_Science_309_131
PubMedID: 15994557
Gene_locus related to this paper: thean-q4u9u6 , thean-q4ub48 , thean-q4ubz1 , thean-q4uc78 , thean-q4uc93 , thean-q4uck1 , thean-q4udw9 , thean-q4ue56 , thean-q4uf06 , thean-q4ug98 , thean-q4uhj9 , thepa-q4n349

Title : Genome sequence of the human malaria parasite Plasmodium falciparum - Gardner_2002_Nature_419_498
Author(s) : Gardner MJ , Hall N , Fung E , White O , Berriman M , Hyman RW , Carlton JM , Pain A , Nelson KE , Bowman S , Paulsen IT , James K , Eisen JA , Rutherford K , Salzberg SL , Craig A , Kyes S , Chan MS , Nene V , Shallom SJ , Suh B , Peterson J , Angiuoli S , Pertea M , Allen J , Selengut J , Haft D , Mather MW , Vaidya AB , Martin DM , Fairlamb AH , Fraunholz MJ , Roos DS , Ralph SA , McFadden GI , Cummings LM , Subramanian GM , Mungall C , Venter JC , Carucci DJ , Hoffman SL , Newbold C , Davis RW , Fraser CM , Barrell B
Ref : Nature , 419 :498 , 2002
Abstract : The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host-parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.
ESTHER : Gardner_2002_Nature_419_498
PubMedSearch : Gardner_2002_Nature_419_498
PubMedID: 12368864
Gene_locus related to this paper: plaf7-c0h4q4 , plaf7-q8i5y6 , plaf7-q8iik5 , plafa-PF10.0018 , plafa-PF10.0020 , plafa-PF10.0379 , plafa-PF11.0211 , plafa-PF11.0276 , plafa-PF11.0441 , plafa-PF14.0015 , plafa-PF14.0017 , plafa-PF14.0099 , plafa-PF14.0250 , plafa-PF14.0395 , plafa-PF14.0737 , plafa-PF14.0738 , plafa-PFL2530W

Title : Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14 - Gardner_2002_Nature_419_531
Author(s) : Gardner MJ , Shallom SJ , Carlton JM , Salzberg SL , Nene V , Shoaibi A , Ciecko A , Lynn J , Rizzo M , Weaver B , Jarrahi B , Brenner M , Parvizi B , Tallon L , Moazzez A , Granger D , Fujii C , Hansen C , Pederson J , Feldblyum T , Peterson J , Suh B , Angiuoli S , Pertea M , Allen J , Selengut J , White O , Cummings LM , Smith HO , Adams MD , Venter JC , Carucci DJ , Hoffman SL , Fraser CM
Ref : Nature , 419 :531 , 2002
Abstract : The mosquito-borne malaria parasite Plasmodium falciparum kills an estimated 0.7-2.7 million people every year, primarily children in sub-Saharan Africa. Without effective interventions, a variety of factors-including the spread of parasites resistant to antimalarial drugs and the increasing insecticide resistance of mosquitoes-may cause the number of malaria cases to double over the next two decades. To stimulate basic research and facilitate the development of new drugs and vaccines, the genome of Plasmodium falciparum clone 3D7 has been sequenced using a chromosome-by-chromosome shotgun strategy. We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome.
ESTHER : Gardner_2002_Nature_419_531
PubMedSearch : Gardner_2002_Nature_419_531
PubMedID: 12368868
Gene_locus related to this paper: plafa-MAL3P8.11