Selengut J

References (11)

Title : Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition - Joardar_2005_J.Bacteriol_187_6488
Author(s) : Joardar V , Lindeberg M , Jackson RW , Selengut J , Dodson R , Brinkac LM , Daugherty SC , Deboy R , Durkin AS , Giglio MG , Madupu R , Nelson WC , Rosovitz MJ , Sullivan S , Crabtree J , Creasy T , Davidsen T , Haft DH , Zafar N , Zhou L , Halpin R , Holley T , Khouri H , Feldblyum T , White O , Fraser CM , Chatterjee AK , Cartinhour S , Schneider DJ , Mansfield J , Collmer A , Buell CR
Ref : Journal of Bacteriology , 187 :6488 , 2005
Abstract : Pseudomonas syringae pv. phaseolicola, a gram-negative bacterial plant pathogen, is the causal agent of halo blight of bean. In this study, we report on the genome sequence of P. syringae pv. phaseolicola isolate 1448A, which encodes 5,353 open reading frames (ORFs) on one circular chromosome (5,928,787 bp) and two plasmids (131,950 bp and 51,711 bp). Comparative analyses with a phylogenetically divergent pathovar, P. syringae pv. tomato DC3000, revealed a strong degree of conservation at the gene and genome levels. In total, 4,133 ORFs were identified as putative orthologs in these two pathovars using a reciprocal best-hit method, with 3,941 ORFs present in conserved, syntenic blocks. Although these two pathovars are highly similar at the physiological level, they have distinct host ranges; 1448A causes disease in beans, and DC3000 is pathogenic on tomato and Arabidopsis. Examination of the complement of ORFs encoding virulence, fitness, and survival factors revealed a substantial, but not complete, overlap between these two pathovars. Another distinguishing feature between the two pathovars is their distinctive sets of transposable elements. With access to a fifth complete pseudomonad genome sequence, we were able to identify 3,567 ORFs that likely comprise the core Pseudomonas genome and 365 ORFs that are P. syringae specific.
ESTHER : Joardar_2005_J.Bacteriol_187_6488
PubMedSearch : Joardar_2005_J.Bacteriol_187_6488
PubMedID: 16159782
Gene_locus related to this paper: pse14-q48cb3 , pse14-q48ck7 , pse14-q48cs3 , pse14-q48ct2 , pse14-q48d82 , pse14-q48da3 , pse14-q48dj9 , pse14-q48dq5 , pse14-q48e33 , pse14-q48es1 , pse14-q48f84 , pse14-q48fg2 , pse14-q48g47 , pse14-q48g51 , pse14-q48gq9 , pse14-q48h40 , pse14-q48ha4 , pse14-q48hb4 , pse14-q48he1 , pse14-q48hq0 , pse14-q48hq2 , pse14-q48ia0 , pse14-q48im0 , pse14-q48j48 , pse14-q48ji2 , pse14-q48k54 , pse14-q48k55 , pse14-q48k63 , pse14-q48kc1 , pse14-q48kt9 , pse14-q48ku0 , pse14-q48lb6 , pse14-q48lj1 , pse14-q48ln2 , pse14-q48m56 , pse14-q48mh5 , pse14-q48mq7 , pse14-q48nt0 , pse14-q48p24 , pse14-q48pi7 , pse14-q48pi8 , pse14-q48pi9 , pse14-q48pq2 , pse14-q48pq5 , psesm-METX , psesm-q87y20 , psesm-q889k3 , psesy-PIP , psesy-PSPTO0162 , psesy-PSPTO1766 , psesy-PSPTO2134 , psesy-PSPTO3135 , pseu2-q4zwv7 , psesg-e7p3i0

Title : Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial pan-genome - Tettelin_2005_Proc.Natl.Acad.Sci.U.S.A_102_13950
Author(s) : Tettelin H , Masignani V , Cieslewicz MJ , Donati C , Medini D , Ward NL , Angiuoli SV , Crabtree J , Jones AL , Durkin AS , DeBoy RT , Davidsen TM , Mora M , Scarselli M , Margarit y Ros I , Peterson JD , Hauser CR , Sundaram JP , Nelson WC , Madupu R , Brinkac LM , Dodson RJ , Rosovitz MJ , Sullivan SA , Daugherty SC , Haft DH , Selengut J , Gwinn ML , Zhou L , Zafar N , Khouri H , Radune D , Dimitrov G , Watkins K , O'Connor KJ , Smith S , Utterback TR , White O , Rubens CE , Grandi G , Madoff LC , Kasper DL , Telford JL , Wessels MR , Rappuoli R , Fraser CM
Ref : Proc Natl Acad Sci U S A , 102 :13950 , 2005
Abstract : The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single genome does not reflect how genetic variability drives pathogenesis within a bacterial species and also limits genome-wide screens for vaccine candidates or for antimicrobial targets. We have generated the genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans. Analysis of these genomes and those available in databases showed that the S. agalactiae species can be described by a pan-genome consisting of a core genome shared by all isolates, accounting for approximately 80% of any single genome, plus a dispensable genome consisting of partially shared and strain-specific genes. Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactiae pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.
ESTHER : Tettelin_2005_Proc.Natl.Acad.Sci.U.S.A_102_13950
PubMedSearch : Tettelin_2005_Proc.Natl.Acad.Sci.U.S.A_102_13950
PubMedID: 16172379
Gene_locus related to this paper: strag-ESTA , strag-GBS0040 , strag-GBS0107 , strag-GBS1828 , strag-pepx , strag-q3dah6 , strag-SAG0246 , strag-SAG0383 , strag-SAG0679 , strag-SAG0680 , strag-SAG0785 , strag-SAG0912 , strag-SAG1562 , strag-SAG2132

Title : The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough - Heidelberg_2004_Nat.Biotechnol_22_554
Author(s) : Heidelberg JF , Seshadri R , Haveman SA , Hemme CL , Paulsen IT , Kolonay JF , Eisen JA , Ward N , Methe B , Brinkac LM , Daugherty SC , DeBoy RT , Dodson RJ , Durkin AS , Madupu R , Nelson WC , Sullivan SA , Fouts D , Haft DH , Selengut J , Peterson JD , Davidsen TM , Zafar N , Zhou L , Radune D , Dimitrov G , Hance M , Tran K , Khouri H , Gill J , Utterback TR , Feldblyum TV , Wall JD , Voordouw G , Fraser CM
Ref : Nat Biotechnol , 22 :554 , 2004
Abstract : Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.
ESTHER : Heidelberg_2004_Nat.Biotechnol_22_554
PubMedSearch : Heidelberg_2004_Nat.Biotechnol_22_554
PubMedID: 15077118
Gene_locus related to this paper: desvh-q72b36 , desvh-q72ed6 , desvh-q728i3 , desvh-q729w4 , desvh-q72b15

Title : Whole genome comparisons of serotype 4b and 1\/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species - Nelson_2004_Nucleic.Acids.Res_32_2386
Author(s) : Nelson KE , Fouts DE , Mongodin EF , Ravel J , DeBoy RT , Kolonay JF , Rasko DA , Angiuoli SV , Gill SR , Paulsen IT , Peterson J , White O , Nelson WC , Nierman W , Beanan MJ , Brinkac LM , Daugherty SC , Dodson RJ , Durkin AS , Madupu R , Haft DH , Selengut J , Van Aken S , Khouri H , Fedorova N , Forberger H , Tran B , Kathariou S , Wonderling LD , Uhlich GA , Bayles DO , Luchansky JB , Fraser CM
Ref : Nucleic Acids Research , 32 :2386 , 2004
Abstract : The genomes of three strains of Listeria monocytogenes that have been associated with food-borne illness in the USA were subjected to whole genome comparative analysis. A total of 51, 97 and 69 strain-specific genes were identified in L.monocytogenes strains F2365 (serotype 4b, cheese isolate), F6854 (serotype 1/2a, frankfurter isolate) and H7858 (serotype 4b, meat isolate), respectively. Eighty-three genes were restricted to serotype 1/2a and 51 to serotype 4b strains. These strain- and serotype-specific genes probably contribute to observed differences in pathogenicity, and the ability of the organisms to survive and grow in their respective environmental niches. The serotype 1/2a-specific genes include an operon that encodes the rhamnose biosynthetic pathway that is associated with teichoic acid biosynthesis, as well as operons for five glycosyl transferases and an adenine-specific DNA methyltransferase. A total of 8603 and 105 050 high quality single nucleotide polymorphisms (SNPs) were found on the draft genome sequences of strain H7858 and strain F6854, respectively, when compared with strain F2365. Whole genome comparative analyses revealed that the L.monocytogenes genomes are essentially syntenic, with the majority of genomic differences consisting of phage insertions, transposable elements and SNPs.
ESTHER : Nelson_2004_Nucleic.Acids.Res_32_2386
PubMedSearch : Nelson_2004_Nucleic.Acids.Res_32_2386
PubMedID: 15115801
Gene_locus related to this paper: lismc-c1l0d9 , lismf-q71xq4 , lismo-LMO0110 , lismo-LMO0493 , lismo-LMO0580 , lismo-LMO0752 , lismo-LMO0760 , lismo-LMO0857 , lismo-LMO0950 , lismo-LMO0951 , lismo-LMO0977 , lismo-LMO1128 , lismo-LMO1258 , lismo-LMO1674 , lismo-LMO2089 , lismo-LMO2109 , lismo-LMO2433 , lismo-LMO2450 , lismo-LMO2452 , lismo-LMO2453 , lismo-LMO2578 , lismo-LMO2677 , lismo-LMO2755 , lismo-metx

Title : Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment - Moran_2004_Nature_432_910
Author(s) : Moran MA , Buchan A , Gonzalez JM , Heidelberg JF , Whitman WB , Kiene RP , Henriksen JR , King GM , Belas R , Fuqua C , Brinkac L , Lewis M , Johri S , Weaver B , Pai G , Eisen JA , Rahe E , Sheldon WM , Ye W , Miller TR , Carlton J , Rasko DA , Paulsen IT , Ren Q , Daugherty SC , DeBoy RT , Dodson RJ , Durkin AS , Madupu R , Nelson WC , Sullivan SA , Rosovitz MJ , Haft DH , Selengut J , Ward N
Ref : Nature , 432 :910 , 2004
Abstract : Since the recognition of prokaryotes as essential components of the oceanic food web, bacterioplankton have been acknowledged as catalysts of most major biogeochemical processes in the sea. Studying heterotrophic bacterioplankton has been challenging, however, as most major clades have never been cultured or have only been grown to low densities in sea water. Here we describe the genome sequence of Silicibacter pomeroyi, a member of the marine Roseobacter clade (Fig. 1), the relatives of which comprise approximately 10-20% of coastal and oceanic mixed-layer bacterioplankton. This first genome sequence from any major heterotrophic clade consists of a chromosome (4,109,442 base pairs) and megaplasmid (491,611 base pairs). Genome analysis indicates that this organism relies upon a lithoheterotrophic strategy that uses inorganic compounds (carbon monoxide and sulphide) to supplement heterotrophy. Silicibacter pomeroyi also has genes advantageous for associations with plankton and suspended particles, including genes for uptake of algal-derived compounds, use of metabolites from reducing microzones, rapid growth and cell-density-dependent regulation. This bacterium has a physiology distinct from that of marine oligotrophs, adding a new strategy to the recognized repertoire for coping with a nutrient-poor ocean.
ESTHER : Moran_2004_Nature_432_910
PubMedSearch : Moran_2004_Nature_432_910
PubMedID: 15602564
Gene_locus related to this paper: silpo-q5lke5 , silpo-q5lke7 , silpo-q5lke8 , silpo-q5lkk5 , silpo-q5lkv2 , silpo-q5lln9 , silpo-q5llu0 , silpo-q5llu2 , silpo-q5llx5 , silpo-q5lm66 , silpo-q5lmb9 , silpo-q5lml9 , silpo-q5lnp6 , silpo-q5lp28 , silpo-q5lp48 , silpo-q5lp56 , silpo-q5lpa5 , silpo-q5lpf7 , silpo-q5lpy6 , silpo-q5lrk1 , silpo-q5lsn7 , silpo-q5ltb5 , silpo-q5ltk0 , silpo-q5ltm5 , silpo-q5ltw8 , silpo-q5ltw9 , silpo-q5ltx1 , silpo-q5ltx5 , silpo-q5lu02 , silpo-q5lv12 , silpo-q5lv17 , silpo-q5lv53 , silpo-q5lvg9 , silpo-q5lw35 , silpo-q5lwk9 , silpo-q5lws0

Title : Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes - Seshadri_2004_Proc.Natl.Acad.Sci.U.S.A_101_5646
Author(s) : Seshadri R , Myers GS , Tettelin H , Eisen JA , Heidelberg JF , Dodson RJ , Davidsen TM , DeBoy RT , Fouts DE , Haft DH , Selengut J , Ren Q , Brinkac LM , Madupu R , Kolonay J , Durkin SA , Daugherty SC , Shetty J , Shvartsbeyn A , Gebregeorgis E , Geer K , Tsegaye G , Malek J , Ayodeji B , Shatsman S , McLeod MP , Smajs D , Howell JK , Pal S , Amin A , Vashisth P , McNeill TZ , Xiang Q , Sodergren E , Baca E , Weinstock GM , Norris SJ , Fraser CM , Paulsen IT
Ref : Proc Natl Acad Sci U S A , 101 :5646 , 2004
Abstract : We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.
ESTHER : Seshadri_2004_Proc.Natl.Acad.Sci.U.S.A_101_5646
PubMedSearch : Seshadri_2004_Proc.Natl.Acad.Sci.U.S.A_101_5646
PubMedID: 15064399
Gene_locus related to this paper: trede-q73j01 , trede-q73kf5 , trede-q73kp3 , trede-q73ks1 , trede-q73nf8 , trede-q73qt5 , trede-q73qv0 , trede-q73ra4 , trede-q73ri8 , trede-Q93EK3 , trede-TDE0521

Title : Structural flexibility in the Burkholderia mallei genome - Nierman_2004_Proc.Natl.Acad.Sci.U.S.A_101_14246
Author(s) : Nierman WC , DeShazer D , Kim HS , Tettelin H , Nelson KE , Feldblyum T , Ulrich RL , Ronning CM , Brinkac LM , Daugherty SC , Davidsen TD , DeBoy RT , Dimitrov G , Dodson RJ , Durkin AS , Gwinn ML , Haft DH , Khouri H , Kolonay JF , Madupu R , Mohammoud Y , Nelson WC , Radune D , Romero CM , Sarria S , Selengut J , Shamblin C , Sullivan SA , White O , Yu Y , Zafar N , Zhou L , Fraser CM
Ref : Proc Natl Acad Sci U S A , 101 :14246 , 2004
Abstract : The complete genome sequence of Burkholderia mallei ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. B. mallei, the etiologic agent of glanders, has come under renewed scientific investigation as a result of recent concerns about its past and potential future use as a biological weapon. Genome analysis identified a number of putative virulence factors whose function was supported by comparative genome hybridization and expression profiling of the bacterium in hamster liver in vivo. The genome contains numerous insertion sequence elements that have mediated extensive deletions and rearrangements of the genome relative to Burkholderia pseudomallei. The genome also contains a vast number (>12,000) of simple sequence repeats. Variation in simple sequence repeats in key genes can provide a mechanism for generating antigenic variation that may account for the mammalian host's inability to mount a durable adaptive immune response to a B. mallei infection.
ESTHER : Nierman_2004_Proc.Natl.Acad.Sci.U.S.A_101_14246
PubMedSearch : Nierman_2004_Proc.Natl.Acad.Sci.U.S.A_101_14246
PubMedID: 15377793
Gene_locus related to this paper: burma-a5j5w8 , burma-a5tj72 , burma-a5tq93 , burma-metx , burma-q62a61 , burma-q62ar2.1 , burma-q62ar2.2 , burma-q62ax8 , burma-q62b60 , burma-q62b79 , burma-q62bh9 , burma-q62bl4 , burma-q62bl7 , burma-q62c00 , burma-q62cg5 , burma-q62d41 , burma-q62d56 , burma-q62d83 , burma-q62dg2 , burma-q62du7 , burma-q62e67 , burma-q62eb8 , burma-q62ed8 , burma-q62f28 , burma-q62fx7 , burma-q62g26 , burma-q62gx9 , burma-q62gy2 , burma-q62hq2 , burma-q62i62 , burma-q62ib8 , burma-q62ie8 , burma-q62j07 , burma-q62j15 , burma-q62jn5 , burma-q62jy7 , burma-q62kb7 , burma-q62kg0 , burma-q62kh9 , burma-q62lp7 , burma-q62m40 , burma-q62mc3 , burma-q62mf4 , burma-q62mq7 , burma-q629m1 , burma-q629p4 , burma-q629u0 , burps-q3v7s4 , burps-hboh

Title : The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000 - Buell_2003_Proc.Natl.Acad.Sci.U.S.A_100_10181
Author(s) : Buell CR , Joardar V , Lindeberg M , Selengut J , Paulsen IT , Gwinn ML , Dodson RJ , DeBoy RT , Durkin AS , Kolonay JF , Madupu R , Daugherty S , Brinkac L , Beanan MJ , Haft DH , Nelson WC , Davidsen T , Zafar N , Zhou L , Liu J , Yuan Q , Khouri H , Fedorova N , Tran B , Russell D , Berry K , Utterback T , Van Aken SE , Feldblyum TV , D'Ascenzo M , Deng WL , Ramos AR , Alfano JR , Cartinhour S , Chatterjee AK , Delaney TP , Lazarowitz SG , Martin GB , Schneider DJ , Tang X , Bender CL , White O , Fraser CM , Collmer A
Ref : Proc Natl Acad Sci U S A , 100 :10181 , 2003
Abstract : We report the complete genome sequence of the model bacterial pathogen Pseudomonas syringae pathovar tomato DC3000 (DC3000), which is pathogenic on tomato and Arabidopsis thaliana. The DC3000 genome (6.5 megabases) contains a circular chromosome and two plasmids, which collectively encode 5,763 ORFs. We identified 298 established and putative virulence genes, including several clusters of genes encoding 31 confirmed and 19 predicted type III secretion system effector proteins. Many of the virulence genes were members of paralogous families and also were proximal to mobile elements, which collectively comprise 7% of the DC3000 genome. The bacterium possesses a large repertoire of transporters for the acquisition of nutrients, particularly sugars, as well as genes implicated in attachment to plant surfaces. Over 12% of the genes are dedicated to regulation, which may reflect the need for rapid adaptation to the diverse environments encountered during epiphytic growth and pathogenesis. Comparative analyses confirmed a high degree of similarity with two sequenced pseudomonads, Pseudomonas putida and Pseudomonas aeruginosa, yet revealed 1,159 genes unique to DC3000, of which 811 lack a known function.
ESTHER : Buell_2003_Proc.Natl.Acad.Sci.U.S.A_100_10181
PubMedSearch : Buell_2003_Proc.Natl.Acad.Sci.U.S.A_100_10181
PubMedID: 12928499
Gene_locus related to this paper: pse14-q48ia0 , psesm-IRP1 , psesm-METX , psesm-q87y20 , psesm-q88a39 , psesm-q881b4 , psesm-q889k3 , psesy-BIOH , psesy-CFA7 , psesy-CFA9 , psesy-CMAT , psesy-ESTA , psesy-IRP4 , psesy-PHAB , psesy-PHAC , psesy-PHAG1 , psesy-PHAG2 , psesy-PIP , psesy-PSPTO0162 , psesy-PSPTO0421 , psesy-PSPTO0508 , psesy-PSPTO0675 , psesy-PSPTO0715 , psesy-PSPTO1154 , psesy-PSPTO1504 , psesy-PSPTO1559 , psesy-PSPTO1580 , psesy-PSPTO1604 , psesy-PSPTO1677 , psesy-PSPTO1766 , psesy-PSPTO1863 , psesy-PSPTO2042 , psesy-PSPTO2134 , psesy-PSPTO2150 , psesy-PSPTO2209 , psesy-PSPTO2217 , psesy-PSPTO2218 , psesy-PSPTO2293 , psesy-PSPTO2495 , psesy-PSPTO2674 , psesy-PSPTO2830 , psesy-PSPTO3135 , psesy-PSPTO3138 , psesy-PSPTO3264 , psesy-PSPTO3282 , psesy-PSPTO3306 , psesy-PSPTO3485 , psesy-PSPTO3572 , psesy-PSPTO3911 , psesy-PSPTO4089 , psesy-PSPTO4178 , psesy-PSPTO4277 , psesy-PSPTO4430 , psesy-PSPTO4519 , psesy-PSPTO4540 , psesy-PSPTO4699 , psesy-PSPTO4708 , psesy-PSPTO4781 , psesy-PSPTO4843 , psesy-PSPTO4964 , psesy-PSPTO5218 , psesy-PSPTO5299 , psesy-PSPTO5448 , psesy-PSPTO5537 , psesy-SYLD , psesy-SYPC , psesy-SYRE , psesm-q87v84

Title : Genome of Geobacter sulfurreducens: metal reduction in subsurface environments - Methe_2003_Science_302_1967
Author(s) : Methe BA , Nelson KE , Eisen JA , Paulsen IT , Nelson W , Heidelberg JF , Wu D , Wu M , Ward N , Beanan MJ , Dodson RJ , Madupu R , Brinkac LM , Daugherty SC , DeBoy RT , Durkin AS , Gwinn M , Kolonay JF , Sullivan SA , Haft DH , Selengut J , Davidsen TM , Zafar N , White O , Tran B , Romero C , Forberger HA , Weidman J , Khouri H , Feldblyum TV , Utterback TR , Van Aken SE , Lovley DR , Fraser CM
Ref : Science , 302 :1967 , 2003
Abstract : The complete genome sequence of Geobacter sulfurreducens, a delta-proteobacterium, reveals unsuspected capabilities, including evidence of aerobic metabolism, one-carbon and complex carbon metabolism, motility, and chemotactic behavior. These characteristics, coupled with the possession of many two-component sensors and many c-type cytochromes, reveal an ability to create alternative, redundant, electron transport networks and offer insights into the process of metal ion reduction in subsurface environments. As well as playing roles in the global cycling of metals and carbon, this organism clearly has the potential for use in bioremediation of radioactive metals and in the generation of electricity.
ESTHER : Methe_2003_Science_302_1967
PubMedSearch : Methe_2003_Science_302_1967
PubMedID: 14671304
Gene_locus related to this paper: geosl-q74a54 , geosl-q74ac8 , geosl-q74eb1 , geosl-q747u4 , geosl-q747v8 , geosl-q749w4

Title : Genome sequence of the human malaria parasite Plasmodium falciparum - Gardner_2002_Nature_419_498
Author(s) : Gardner MJ , Hall N , Fung E , White O , Berriman M , Hyman RW , Carlton JM , Pain A , Nelson KE , Bowman S , Paulsen IT , James K , Eisen JA , Rutherford K , Salzberg SL , Craig A , Kyes S , Chan MS , Nene V , Shallom SJ , Suh B , Peterson J , Angiuoli S , Pertea M , Allen J , Selengut J , Haft D , Mather MW , Vaidya AB , Martin DM , Fairlamb AH , Fraunholz MJ , Roos DS , Ralph SA , McFadden GI , Cummings LM , Subramanian GM , Mungall C , Venter JC , Carucci DJ , Hoffman SL , Newbold C , Davis RW , Fraser CM , Barrell B
Ref : Nature , 419 :498 , 2002
Abstract : The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host-parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.
ESTHER : Gardner_2002_Nature_419_498
PubMedSearch : Gardner_2002_Nature_419_498
PubMedID: 12368864
Gene_locus related to this paper: plaf7-c0h4q4 , plaf7-q8i5y6 , plaf7-q8iik5 , plafa-PF10.0018 , plafa-PF10.0020 , plafa-PF10.0379 , plafa-PF11.0211 , plafa-PF11.0276 , plafa-PF11.0441 , plafa-PF14.0015 , plafa-PF14.0017 , plafa-PF14.0099 , plafa-PF14.0250 , plafa-PF14.0395 , plafa-PF14.0737 , plafa-PF14.0738 , plafa-PFL2530W

Title : Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14 - Gardner_2002_Nature_419_531
Author(s) : Gardner MJ , Shallom SJ , Carlton JM , Salzberg SL , Nene V , Shoaibi A , Ciecko A , Lynn J , Rizzo M , Weaver B , Jarrahi B , Brenner M , Parvizi B , Tallon L , Moazzez A , Granger D , Fujii C , Hansen C , Pederson J , Feldblyum T , Peterson J , Suh B , Angiuoli S , Pertea M , Allen J , Selengut J , White O , Cummings LM , Smith HO , Adams MD , Venter JC , Carucci DJ , Hoffman SL , Fraser CM
Ref : Nature , 419 :531 , 2002
Abstract : The mosquito-borne malaria parasite Plasmodium falciparum kills an estimated 0.7-2.7 million people every year, primarily children in sub-Saharan Africa. Without effective interventions, a variety of factors-including the spread of parasites resistant to antimalarial drugs and the increasing insecticide resistance of mosquitoes-may cause the number of malaria cases to double over the next two decades. To stimulate basic research and facilitate the development of new drugs and vaccines, the genome of Plasmodium falciparum clone 3D7 has been sequenced using a chromosome-by-chromosome shotgun strategy. We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome.
ESTHER : Gardner_2002_Nature_419_531
PubMedSearch : Gardner_2002_Nature_419_531
PubMedID: 12368868
Gene_locus related to this paper: plafa-MAL3P8.11