| Title : Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Abeta by multiple endoproteolytic cleavages within the beta-sheet domain - Sole-Domenech_2018_Proc.Natl.Acad.Sci.U.S.A_115_1493 |
| Author(s) : Sole-Domenech S , Rojas AV , Maisuradze GG , Scheraga HA , Lobel P , Maxfield FR |
| Ref : Proc Natl Acad Sci U S A , 115 :1493 , 2018 |
| Abstract : |
| PubMedSearch : Sole-Domenech_2018_Proc.Natl.Acad.Sci.U.S.A_115_1493 |
| PubMedID: 29378960 |
| Title : Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors - Patel_2015_ChemMedChem_10_253 |
| Author(s) : Patel JZ , Nevalainen TJ , Savinainen JR , Adams Y , Laitinen T , Runyon RS , Vaara M , Ahenkorah S , Kaczor AA , Navia-Paldanius D , Gynther M , Aaltonen N , Joharapurkar AA , Jain MR , Haka AS , Maxfield FR , Laitinen JT , Parkkari T |
| Ref : ChemMedChem , 10 :253 , 2015 |
| Abstract : |
| PubMedSearch : Patel_2015_ChemMedChem_10_253 |
| PubMedID: 25504894 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics - Rosenbaum_2010_J.Med.Chem_53_5281 |
| Author(s) : Rosenbaum AI , Cosner CC , Mariani CJ , Maxfield FR , Wiest O , Helquist P |
| Ref : Journal of Medicinal Chemistry , 53 :5281 , 2010 |
| Abstract : |
| PubMedSearch : Rosenbaum_2010_J.Med.Chem_53_5281 |
| PubMedID: 20557099 |
| Title : Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors - Rosenbaum_2009_Biochim.Biophys.Acta_1791_1155 |
| Author(s) : Rosenbaum AI , Rujoi M , Huang AY , Du H , Grabowski GA , Maxfield FR |
| Ref : Biochimica & Biophysica Acta , 1791 :1155 , 2009 |
| Abstract : |
| PubMedSearch : Rosenbaum_2009_Biochim.Biophys.Acta_1791_1155 |
| PubMedID: 19699313 |
| Title : Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl protein degradation - Buton_1999_J.Biol.Chem_274_32112 |
| Author(s) : Buton X , Mamdouh Z , Ghosh R , Du H , Kuriakose G , Beatini N , Grabowski GA , Maxfield FR , Tabas I |
| Ref : Journal of Biological Chemistry , 274 :32112 , 1999 |
| Abstract : |
| PubMedSearch : Buton_1999_J.Biol.Chem_274_32112 |
| PubMedID: 10542246 |