Parkkari T

References (11)

Title : In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)m ethanone (JJKK-048) - Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62
Author(s) : Aaltonen N , Kedzierska E , Orzelska-Gorka J , Lehtonen M , Navia-Paldanius D , Jakupovic H , Savinainen JR , Nevalainen T , Laitinen JT , Parkkari T , Gynther M
Ref : Journal of Pharmacology & Experimental Therapeutics , 359 :62 , 2016
Abstract :
PubMedSearch : Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62
PubMedID: 27451409

Title : Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors - Patel_2015_Bioorg.Med.Chem_23_6335
Author(s) : Patel JZ , van Bruchem J , Laitinen T , Kaczor AA , Navia-Paldanius D , Parkkari T , Savinainen JR , Laitinen JT , Nevalainen TJ
Ref : Bioorganic & Medicinal Chemistry , 23 :6335 , 2015
Abstract :
PubMedSearch : Patel_2015_Bioorg.Med.Chem_23_6335
PubMedID: 26344596

Title : Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors - Patel_2015_ChemMedChem_10_253
Author(s) : Patel JZ , Nevalainen TJ , Savinainen JR , Adams Y , Laitinen T , Runyon RS , Vaara M , Ahenkorah S , Kaczor AA , Navia-Paldanius D , Gynther M , Aaltonen N , Joharapurkar AA , Jain MR , Haka AS , Maxfield FR , Laitinen JT , Parkkari T
Ref : ChemMedChem , 10 :253 , 2015
Abstract :
PubMedSearch : Patel_2015_ChemMedChem_10_253
PubMedID: 25504894
Gene_locus related to this paper: human-ABHD6

Title : Loratadine analogues as MAGL inhibitors - Patel_2015_Bioorg.Med.Chem.Lett_25_1436
Author(s) : Patel JZ , Ahenkorah S , Vaara M , Staszewski M , Adams Y , Laitinen T , Navia-Paldanius D , Parkkari T , Savinainen JR , Walczynski K , Laitinen JT , Nevalainen TJ
Ref : Bioorganic & Medicinal Chemistry Lett , 25 :1436 , 2015
Abstract :
PubMedSearch : Patel_2015_Bioorg.Med.Chem.Lett_25_1436
PubMedID: 25752982

Title : Comparative molecular field analysis and molecular dynamics studies of alpha\/beta hydrolase domain containing 6 (ABHD6) inhibitors - Kaczor_2015_J.Mol.Model_21_2789
Author(s) : Kaczor AA , Targowska-Duda KM , Patel JZ , Laitinen T , Parkkari T , Adams Y , Nevalainen TJ , Poso A
Ref : J Mol Model , 21 :2789 , 2015
Abstract :
PubMedSearch : Kaczor_2015_J.Mol.Model_21_2789
PubMedID: 26350245

Title : Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) - Korhonen_2014_Bioorg.Med.Chem_22_6694
Author(s) : Korhonen J , Kuusisto A , van Bruchem J , Patel JZ , Laitinen T , Navia-Paldanius D , Laitinen JT , Savinainen JR , Parkkari T , Nevalainen TJ
Ref : Bioorganic & Medicinal Chemistry , 22 :6694 , 2014
Abstract :
PubMedSearch : Korhonen_2014_Bioorg.Med.Chem_22_6694
PubMedID: 25282655

Title : Discovery of Triterpenoids as Reversible Inhibitors of alpha\/beta-hydrolase Domain Containing 12 (ABHD12) - Parkkari_2014_PLoS.One_9_e98286
Author(s) : Parkkari T , Haavikko R , Laitinen T , Navia-Paldanius D , Rytilahti R , Vaara M , Lehtonen M , Alakurtti S , Yli-Kauhaluoma J , Nevalainen T , Savinainen JR , Laitinen JT
Ref : PLoS ONE , 9 :e98286 , 2014
Abstract :
PubMedSearch : Parkkari_2014_PLoS.One_9_e98286
PubMedID: 24879289
Gene_locus related to this paper: human-ABHD12

Title : Mutation of cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency - Laitinen_2014_Mol.Pharmacol_85_510
Author(s) : Laitinen T , Navia-Paldanius D , Rytilahti R , Marjamaa JJ , Karizkova J , Parkkari T , Pantsar T , Poso A , Laitinen JT , Savinainen JR
Ref : Molecular Pharmacology , 85 :510 , 2014
Abstract :
PubMedSearch : Laitinen_2014_Mol.Pharmacol_85_510
PubMedID: 24368842
Gene_locus related to this paper: human-MGLL

Title : Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5\/ABHD16A) - Savinainen_2014_PLoS.One_9_e109869
Author(s) : Savinainen JR , Patel JZ , Parkkari T , Navia-Paldanius D , Marjamaa JJ , Laitinen T , Nevalainen T , Laitinen JT
Ref : PLoS ONE , 9 :e109869 , 2014
Abstract :
PubMedSearch : Savinainen_2014_PLoS.One_9_e109869
PubMedID: 25290914
Gene_locus related to this paper: human-ABHD16A , mouse-Abhd16a

Title : Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) - Savinainen_2014_Mol.Pharmacol_86_522
Author(s) : Savinainen JR , Kansanen E , Pantsar T , Navia-Paldanius D , Parkkari T , Lehtonen M , Laitinen T , Nevalainen T , Poso A , Levonen AL , Laitinen JT
Ref : Molecular Pharmacology , 86 :522 , 2014
Abstract :
PubMedSearch : Savinainen_2014_Mol.Pharmacol_86_522
PubMedID: 25140003
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling - Kasnanen_2013_Eur.J.Pharm.Sci_49_423
Author(s) : Kasnanen H , Minkkila A , Taupila S , Patel JZ , Parkkari T , Lahtela-Kakkonen M , Saario SM , Nevalainen T , Poso A
Ref : Eur J Pharm Sci , 49 :423 , 2013
Abstract :
PubMedSearch : Kasnanen_2013_Eur.J.Pharm.Sci_49_423
PubMedID: 23557840
Gene_locus related to this paper: human-MGLL