| Title : Brain Exposure to the Macrocyclic ALK Inhibitor Zotizalkib is Restricted by ABCB1, and Its Plasma Disposition is Affected by Mouse Carboxylesterase 1c - Rijmers_2024_Mol.Pharm__ |
| Author(s) : Rijmers J , Sparidans RW , Acda M , Loos NHC , Epeslidou E , Bui V , Lebre MC , Tibben M , Beijnen JH , Schinkel AH |
| Ref : Mol Pharm , : , 2024 |
| Abstract : |
| PubMedSearch : Rijmers_2024_Mol.Pharm__ |
| PubMedID: 39312722 |
| Title : ABCB1 attenuates brain exposure to the KRAS(G12C) inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure - Rijmers_2024_Biomed.Pharmacother_175_116720 |
| Author(s) : Rijmers J , Retmana IA , Bui V , Arguedas D , Lebre MC , Sparidans RW , Beijnen JH , Schinkel AH |
| Ref : Biomed Pharmacother , 175 :116720 , 2024 |
| Abstract : |
| PubMedSearch : Rijmers_2024_Biomed.Pharmacother_175_116720 |
| PubMedID: 38733773 |
| Title : Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice - Loos_2024_Mol.Pharm__ |
| Author(s) : Loos NHC , Ferreira Martins ML , Rijmers J , de Jong D , Lebre MC , Tibben M , Beijnen JH , Schinkel AH |
| Ref : Mol Pharm , : , 2024 |
| Abstract : |
| PubMedSearch : Loos_2024_Mol.Pharm__ |
| PubMedID: 38423793 |
| Title : Pharmacokinetics of the KRAS(G12C) inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c - Loos_2023_Biomed.Pharmacother_166_115304 |
| Author(s) : Loos NHC , Retmana IA , Rijmers J , Wang Y , Gan C , Lebre MC , Sparidans RW , Beijnen JH , Schinkel AH |
| Ref : Biomed Pharmacother , 166 :115304 , 2023 |
| Abstract : |
| PubMedSearch : Loos_2023_Biomed.Pharmacother_166_115304 |
| PubMedID: 37586117 |