Title : Brain Exposure to the Macrocyclic ALK Inhibitor Zotizalkib is Restricted by ABCB1, and Its Plasma Disposition is Affected by Mouse Carboxylesterase 1c - Rijmers_2024_Mol.Pharm__ |
Author(s) : Rijmers J , Sparidans RW , Acda M , Loos NHC , Epeslidou E , Bui V , Lebre MC , Tibben M , Beijnen JH , Schinkel AH |
Ref : Mol Pharm , : , 2024 |
Abstract : |
PubMedSearch : Rijmers_2024_Mol.Pharm__ |
PubMedID: 39312722 |
Title : ABCB1 attenuates brain exposure to the KRAS(G12C) inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure - Rijmers_2024_Biomed.Pharmacother_175_116720 |
Author(s) : Rijmers J , Retmana IA , Bui V , Arguedas D , Lebre MC , Sparidans RW , Beijnen JH , Schinkel AH |
Ref : Biomed Pharmacother , 175 :116720 , 2024 |
Abstract : |
PubMedSearch : Rijmers_2024_Biomed.Pharmacother_175_116720 |
PubMedID: 38733773 |
Title : Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice - Wang_2024_Acta.Pharmacol.Sin__ |
Author(s) : Wang YG , Gan CP , Beukers-Korver J , Rosing H , Li WL , Wagenaar E , Lebre MC , Song JY , Pritchard C , Bin Ali R , Huijbers I , Beijnen JH , Schinkel AH |
Ref : Acta Pharmacol Sin , : , 2024 |
Abstract : |
PubMedSearch : Wang_2024_Acta.Pharmacol.Sin__ |
PubMedID: 39496863 |
Gene_locus related to this paper: human-CES2 , mouse-Ces2a , mouse-Ces2b , mouse-Ces2c , mouse-Ces2d-ps , mouse-Ces2e , mouse-Ces2f , mouse-Ces2g , mouse-Ces2h |
Title : Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice - Loos_2024_Mol.Pharm__ |
Author(s) : Loos NHC , Ferreira Martins ML , Rijmers J , de Jong D , Lebre MC , Tibben M , Beijnen JH , Schinkel AH |
Ref : Mol Pharm , : , 2024 |
Abstract : |
PubMedSearch : Loos_2024_Mol.Pharm__ |
PubMedID: 38423793 |
Title : Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism - Gan_2023_Acta.Pharm.Sin.B_13_618 |
Author(s) : Gan C , Wang J , Martinez-Chavez A , Hillebrand M , de Vries N , Beukers J , Wagenaar E , Wang Y , Lebre MC , Rosing H , Klarenbeek S , Ali RB , Pritchard C , Huijbers I , Beijnen JH , Schinkel AH |
Ref : Acta Pharm Sin B , 13 :618 , 2023 |
Abstract : |
PubMedSearch : Gan_2023_Acta.Pharm.Sin.B_13_618 |
PubMedID: 36873183 |
Gene_locus related to this paper: mouse-Ces1a , mouse-Ces1b , mouse-Ces1c , mouse-Ces1d , mouse-Ces1e , mouse-Ces1f , mouse-Ces1g , mouse-Ces1h |
Title : Pharmacokinetics of the KRAS(G12C) inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c - Loos_2023_Biomed.Pharmacother_166_115304 |
Author(s) : Loos NHC , Retmana IA , Rijmers J , Wang Y , Gan C , Lebre MC , Sparidans RW , Beijnen JH , Schinkel AH |
Ref : Biomed Pharmacother , 166 :115304 , 2023 |
Abstract : |
PubMedSearch : Loos_2023_Biomed.Pharmacother_166_115304 |
PubMedID: 37586117 |
Title : Natural deletion of mouse carboxylesterases Ces1c\/d\/e impacts drug metabolism and metabolic syndrome development - Gan_2023_Biomed.Pharmacother_164_114956 |
Author(s) : Gan C , Wang J , Wang Y , Martinez-Chavez A , Hillebrand M , de Vries N , Beukers J , Lebre MC , Wagenaar E , Rosing H , Klarenbeek S , Bleijerveld OB , Song JY , Altelaar M , Beijnen JH , Schinkel AH |
Ref : Biomed Pharmacother , 164 :114956 , 2023 |
Abstract : |
PubMedSearch : Gan_2023_Biomed.Pharmacother_164_114956 |
PubMedID: 37267638 |
Gene_locus related to this paper: human-CES1 , mouse-Ces1c , mouse-Ces1d , mouse-Ces1e |
Title : P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice - Tang_2015_Mol.Pharm_12_3714 |
Author(s) : Tang SC , Kort A , Cheung KL , Rosing H , Fukami T , Durmus S , Wagenaar E , Hendrikx JJ , Nakajima M , van Vlijmen BJ , Beijnen JH , Schinkel AH |
Ref : Mol Pharm , 12 :3714 , 2015 |
Abstract : |
PubMedSearch : Tang_2015_Mol.Pharm_12_3714 |
PubMedID: 26317243 |
Title : OATP1A\/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice - Iusuf_2014_Mol.Cancer.Ther_13_492 |
Author(s) : Iusuf D , Ludwig M , Elbatsh A , van Esch A , van de Steeg E , Wagenaar E , van der Valk M , Lin F , van Tellingen O , Schinkel AH |
Ref : Mol Cancer Ther , 13 :492 , 2014 |
Abstract : |
PubMedSearch : Iusuf_2014_Mol.Cancer.Ther_13_492 |
PubMedID: 24194565 |
Title : P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice - Tang_2014_Clin.Cancer.Res_20_3133 |
Author(s) : Tang SC , Sparidans RW , Cheung KL , Fukami T , Durmus S , Wagenaar E , Yokoi T , van Vlijmen BJ , Beijnen JH , Schinkel AH |
Ref : Clin Cancer Research , 20 :3133 , 2014 |
Abstract : |
PubMedSearch : Tang_2014_Clin.Cancer.Res_20_3133 |
PubMedID: 24727322 |
Title : P-glycoprotein, multidrug-resistance associated protein 2, cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine - Lagas_2012_Mol.Pharmacol_82_636 |
Author(s) : Lagas JS , Damen CW , van Waterschoot RA , Iusuf D , Beijnen JH , Schinkel AH |
Ref : Molecular Pharmacology , 82 :636 , 2012 |
Abstract : |
PubMedSearch : Lagas_2012_Mol.Pharmacol_82_636 |
PubMedID: 22767610 |
Title : Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse - Kummer_2006_J.Mol.Neurosci_30_67 |
Author(s) : Kummer W , Wiegand S , Akinci S , Schinkel AH , Wess J , Koepsell H , Haberberger RV , Lips KS |
Ref : Journal of Molecular Neuroscience , 30 :67 , 2006 |
Abstract : |
PubMedSearch : Kummer_2006_J.Mol.Neurosci_30_67 |
PubMedID: 17192631 |
Title : Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse - Kummer_2006_Respir.Res_7_65 |
Author(s) : Kummer W , Wiegand S , Akinci S , Wessler I , Schinkel AH , Wess J , Koepsell H , Haberberger RV , Lips KS |
Ref : Respir Res , 7 :65 , 2006 |
Abstract : |
PubMedSearch : Kummer_2006_Respir.Res_7_65 |
PubMedID: 16608531 |