| Title : Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program - Edelmann_2025_ACS.Chem.Neurosci__ |
| Author(s) : Edelmann MR , Gobbi LC , Schmalzbauer S , Beck J , Muller MC , Hau JC , Huber S , Haider A , Wittwer MB , Pavlovic A , Collin L , Heer D , Topp A , Leibrock-Thielen L , Benz J , Hilbert M , Honer M , Grether U |
| Ref : ACS Chem Neurosci , : , 2025 |
| Abstract : |
| PubMedSearch : Edelmann_2025_ACS.Chem.Neurosci__ |
| PubMedID: 40968094 |
| Title : Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization - Nippa_2025_Nat.Commun__ |
| Author(s) : Nippa DF , Atz K , Stenzhorn Y , Muller AT , Tosstorff A , Benz J , Binch H , Burkler M , Haider A , Heer D , Hochstrasser R , Kramer C , Reutlinger M , Schneider P , Shema T , Topp A , Walter A , Wittwer MB , Wolfard J , Kuhn B , van der Stelt M , Martin RE , Grether U , Schneider G |
| Ref : Nat Commun , : , 2025 |
| Abstract : |
| PubMedSearch : Nippa_2025_Nat.Commun__ |
| PubMedID: 41290653 |
| Gene_locus related to this paper: human-MGLL |
| Title : Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program - Edelmann_2025_ACS.Chem.Neurosci__ |
| Author(s) : Edelmann MR , Gobbi LC , Schmalzbauer S , Beck J , Muller MC , Hau JC , Huber S , Haider A , Wittwer MB , Pavlovic A , Collin L , Heer D , Topp A , Leibrock-Thielen L , Benz J , Hilbert M , Honer M , Grether U |
| Ref : ACS Chem Neurosci , : , 2025 |
| Abstract : |
| PubMedSearch : Edelmann_2025_ACS.Chem.Neurosci__ |
| PubMedID: 40968094 |
| Title : Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research - Hentsch_2025_J.Am.Chem.Soc__ |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , He Y , Contzen J , Kuhn B , Benz J , Schippers M , Paul J , Leibrock L , Collin L , Wittwer M , Topp A , O'Hara F , Heer D , Hochstrasser R , Blaising J , von Kries JP , Mu L , van der Stelt M , Mergenthaler P , Lipstein N , Grether U , Nazare M |
| Ref : Journal of the American Chemical Society , : , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_J.Am.Chem.Soc__ |
| PubMedID: 40063733 |
| Gene_locus related to this paper: human-MGLL |
| Title : A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase - Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , Paul J , Schippers M , Benz J , Kuhn B , Heer D , Topp A , Esteves Gloria L , Walter A , Hochstrasser R , Wittwer MB , von Kries JP , Collin L , Blaising J , van der Stelt M , Lipstein N , Grether U , Nazare M |
| Ref : Angew Chem Int Ed Engl , :e202413405 , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| PubMedID: 39916545 |
| Gene_locus related to this paper: human-MGLL |
| Title : Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization - Nippa_2025_Nat.Commun__ |
| Author(s) : Nippa DF , Atz K , Stenzhorn Y , Muller AT , Tosstorff A , Benz J , Binch H , Burkler M , Haider A , Heer D , Hochstrasser R , Kramer C , Reutlinger M , Schneider P , Shema T , Topp A , Walter A , Wittwer MB , Wolfard J , Kuhn B , van der Stelt M , Martin RE , Grether U , Schneider G |
| Ref : Nat Commun , : , 2025 |
| Abstract : |
| PubMedSearch : Nippa_2025_Nat.Commun__ |
| PubMedID: 41290653 |
| Gene_locus related to this paper: human-MGLL |
| Title : Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research - Hentsch_2025_J.Am.Chem.Soc__ |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , He Y , Contzen J , Kuhn B , Benz J , Schippers M , Paul J , Leibrock L , Collin L , Wittwer M , Topp A , O'Hara F , Heer D , Hochstrasser R , Blaising J , von Kries JP , Mu L , van der Stelt M , Mergenthaler P , Lipstein N , Grether U , Nazare M |
| Ref : Journal of the American Chemical Society , : , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_J.Am.Chem.Soc__ |
| PubMedID: 40063733 |
| Gene_locus related to this paper: human-MGLL |
| Title : A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase - Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , Paul J , Schippers M , Benz J , Kuhn B , Heer D , Topp A , Esteves Gloria L , Walter A , Hochstrasser R , Wittwer MB , von Kries JP , Collin L , Blaising J , van der Stelt M , Lipstein N , Grether U , Nazare M |
| Ref : Angew Chem Int Ed Engl , :e202413405 , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| PubMedID: 39916545 |
| Gene_locus related to this paper: human-MGLL |
| Title : Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program - Edelmann_2025_ACS.Chem.Neurosci__ |
| Author(s) : Edelmann MR , Gobbi LC , Schmalzbauer S , Beck J , Muller MC , Hau JC , Huber S , Haider A , Wittwer MB , Pavlovic A , Collin L , Heer D , Topp A , Leibrock-Thielen L , Benz J , Hilbert M , Honer M , Grether U |
| Ref : ACS Chem Neurosci , : , 2025 |
| Abstract : |
| PubMedSearch : Edelmann_2025_ACS.Chem.Neurosci__ |
| PubMedID: 40968094 |
| Title : Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization - Nippa_2025_Nat.Commun__ |
| Author(s) : Nippa DF , Atz K , Stenzhorn Y , Muller AT , Tosstorff A , Benz J , Binch H , Burkler M , Haider A , Heer D , Hochstrasser R , Kramer C , Reutlinger M , Schneider P , Shema T , Topp A , Walter A , Wittwer MB , Wolfard J , Kuhn B , van der Stelt M , Martin RE , Grether U , Schneider G |
| Ref : Nat Commun , : , 2025 |
| Abstract : |
| PubMedSearch : Nippa_2025_Nat.Commun__ |
| PubMedID: 41290653 |
| Gene_locus related to this paper: human-MGLL |
| Title : Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research - Hentsch_2025_J.Am.Chem.Soc__ |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , He Y , Contzen J , Kuhn B , Benz J , Schippers M , Paul J , Leibrock L , Collin L , Wittwer M , Topp A , O'Hara F , Heer D , Hochstrasser R , Blaising J , von Kries JP , Mu L , van der Stelt M , Mergenthaler P , Lipstein N , Grether U , Nazare M |
| Ref : Journal of the American Chemical Society , : , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_J.Am.Chem.Soc__ |
| PubMedID: 40063733 |
| Gene_locus related to this paper: human-MGLL |
| Title : A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase - Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , Paul J , Schippers M , Benz J , Kuhn B , Heer D , Topp A , Esteves Gloria L , Walter A , Hochstrasser R , Wittwer MB , von Kries JP , Collin L , Blaising J , van der Stelt M , Lipstein N , Grether U , Nazare M |
| Ref : Angew Chem Int Ed Engl , :e202413405 , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| PubMedID: 39916545 |
| Gene_locus related to this paper: human-MGLL |
| Title : Exploration of (R)-[(11)C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates - He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : He Y , Zheng M , Gu J , Reichert L , Trimborn J , Zhang H , Keller C , Crosby M , Collin L , Heer D , Pavlovic A , Topp A , Wittwer MB , Grether U , Gobbi L , Schibli R , Huang Y , Mu L |
| Ref : Eur J Nucl Med Mol Imaging , : , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 39673602 |
| Title : Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors - Kuhn_2024_J.Med.Chem__ |
| Author(s) : Kuhn B , Ritter M , Hornsperger B , Bell C , Kocer B , Rombach D , Lutz MDR , Gobbi L , Kuratli M , Bartelmus C , Burkler M , Koller R , Tosatti P , Ruf I , Guerard M , Pavlovic A , Stephanus J , O'Hara F , Wetzl D , Saal W , Stihle M , Roth D , Hug M , Huber S , Heer D , Kroll C , Topp A , Schneider M , Gertsch J , Glasmacher S , van der Stelt M , Martella A , Wittwer MB , Collin L , Benz J , Richter H , Grether U |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Kuhn_2024_J.Med.Chem__ |
| PubMedID: 39360636 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells - Gazzi_2024_Chembiochem__e202400704 |
| Author(s) : Gazzi T , Brennecke B , Olikauskas V , Hochstrasser R , Wang H , Keen Chao S , Atz K , Mostinski Y , Topp A , Heer D , Kaufmann I , Ritter M , Gobbi L , Hornsperger B , Wagner B , Richter H , O'Hara F , Wittwer MB , Jul Hansen D , Collin L , Kuhn B , Benz J , Grether U , Nazare M |
| Ref : Chembiochem , :e202400704 , 2024 |
| Abstract : |
| PubMedSearch : Gazzi_2024_Chembiochem__e202400704 |
| PubMedID: 39607084 |
| Gene_locus related to this paper: human-MGLL |
| Title : Exploration of (R)-[(11)C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates - He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : He Y , Zheng M , Gu J , Reichert L , Trimborn J , Zhang H , Keller C , Crosby M , Collin L , Heer D , Pavlovic A , Topp A , Wittwer MB , Grether U , Gobbi L , Schibli R , Huang Y , Mu L |
| Ref : Eur J Nucl Med Mol Imaging , : , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 39673602 |
| Title : Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors - Kuhn_2024_J.Med.Chem__ |
| Author(s) : Kuhn B , Ritter M , Hornsperger B , Bell C , Kocer B , Rombach D , Lutz MDR , Gobbi L , Kuratli M , Bartelmus C , Burkler M , Koller R , Tosatti P , Ruf I , Guerard M , Pavlovic A , Stephanus J , O'Hara F , Wetzl D , Saal W , Stihle M , Roth D , Hug M , Huber S , Heer D , Kroll C , Topp A , Schneider M , Gertsch J , Glasmacher S , van der Stelt M , Martella A , Wittwer MB , Collin L , Benz J , Richter H , Grether U |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Kuhn_2024_J.Med.Chem__ |
| PubMedID: 39360636 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells - Gazzi_2024_Chembiochem__e202400704 |
| Author(s) : Gazzi T , Brennecke B , Olikauskas V , Hochstrasser R , Wang H , Keen Chao S , Atz K , Mostinski Y , Topp A , Heer D , Kaufmann I , Ritter M , Gobbi L , Hornsperger B , Wagner B , Richter H , O'Hara F , Wittwer MB , Jul Hansen D , Collin L , Kuhn B , Benz J , Grether U , Nazare M |
| Ref : Chembiochem , :e202400704 , 2024 |
| Abstract : |
| PubMedSearch : Gazzi_2024_Chembiochem__e202400704 |
| PubMedID: 39607084 |
| Gene_locus related to this paper: human-MGLL |
| Title : Exploration of (R)-[(11)C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates - He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : He Y , Zheng M , Gu J , Reichert L , Trimborn J , Zhang H , Keller C , Crosby M , Collin L , Heer D , Pavlovic A , Topp A , Wittwer MB , Grether U , Gobbi L , Schibli R , Huang Y , Mu L |
| Ref : Eur J Nucl Med Mol Imaging , : , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 39673602 |
| Title : Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors - Kuhn_2024_J.Med.Chem__ |
| Author(s) : Kuhn B , Ritter M , Hornsperger B , Bell C , Kocer B , Rombach D , Lutz MDR , Gobbi L , Kuratli M , Bartelmus C , Burkler M , Koller R , Tosatti P , Ruf I , Guerard M , Pavlovic A , Stephanus J , O'Hara F , Wetzl D , Saal W , Stihle M , Roth D , Hug M , Huber S , Heer D , Kroll C , Topp A , Schneider M , Gertsch J , Glasmacher S , van der Stelt M , Martella A , Wittwer MB , Collin L , Benz J , Richter H , Grether U |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Kuhn_2024_J.Med.Chem__ |
| PubMedID: 39360636 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells - Gazzi_2024_Chembiochem__e202400704 |
| Author(s) : Gazzi T , Brennecke B , Olikauskas V , Hochstrasser R , Wang H , Keen Chao S , Atz K , Mostinski Y , Topp A , Heer D , Kaufmann I , Ritter M , Gobbi L , Hornsperger B , Wagner B , Richter H , O'Hara F , Wittwer MB , Jul Hansen D , Collin L , Kuhn B , Benz J , Grether U , Nazare M |
| Ref : Chembiochem , :e202400704 , 2024 |
| Abstract : |
| PubMedSearch : Gazzi_2024_Chembiochem__e202400704 |
| PubMedID: 39607084 |
| Gene_locus related to this paper: human-MGLL |
| Title : Identification of (R)-[(18)F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development - He_2023_J.Nucl.Med__ |
| Author(s) : He Y , Kramer SD , Grether U , Wittwer MB , Collin L , Kuhn B , Topp A , Heer D , O'Hara F , Honer M , Pavlovic A , Richter H , Ritter M , Rombach D , Keller C , Gobbi L , Mu L |
| Ref : J Nucl Med , : , 2023 |
| Abstract : |
| PubMedSearch : He_2023_J.Nucl.Med__ |
| PubMedID: 38164615 |
| Title : Identification of (R)-[(18)F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development - He_2023_J.Nucl.Med__ |
| Author(s) : He Y , Kramer SD , Grether U , Wittwer MB , Collin L , Kuhn B , Topp A , Heer D , O'Hara F , Honer M , Pavlovic A , Richter H , Ritter M , Rombach D , Keller C , Gobbi L , Mu L |
| Ref : J Nucl Med , : , 2023 |
| Abstract : |
| PubMedSearch : He_2023_J.Nucl.Med__ |
| PubMedID: 38164615 |
| Title : Identification of (R)-[(18)F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development - He_2023_J.Nucl.Med__ |
| Author(s) : He Y , Kramer SD , Grether U , Wittwer MB , Collin L , Kuhn B , Topp A , Heer D , O'Hara F , Honer M , Pavlovic A , Richter H , Ritter M , Rombach D , Keller C , Gobbi L , Mu L |
| Ref : J Nucl Med , : , 2023 |
| Abstract : |
| PubMedSearch : He_2023_J.Nucl.Med__ |
| PubMedID: 38164615 |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |