Title : Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors - Kuhn_2024_J.Med.Chem__ |
Author(s) : Kuhn B , Ritter M , Hornsperger B , Bell C , Kocer B , Rombach D , Lutz MDR , Gobbi L , Kuratli M , Bartelmus C , Burkler M , Koller R , Tosatti P , Ruf I , Guerard M , Pavlovic A , Stephanus J , O'Hara F , Wetzl D , Saal W , Stihle M , Roth D , Hug M , Huber S , Heer D , Kroll C , Topp A , Schneider M , Gertsch J , Glasmacher S , van der Stelt M , Martella A , Wittwer MB , Collin L , Benz J , Richter H , Grether U |
Ref : Journal of Medicinal Chemistry , : , 2024 |
Abstract : |
PubMedSearch : Kuhn_2024_J.Med.Chem__ |
PubMedID: 39360636 |
Gene_locus related to this paper: human-MGLL |
Title : Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells - Gazzi_2024_Chembiochem__e202400704 |
Author(s) : Gazzi T , Brennecke B , Olikauskas V , Hochstrasser R , Wang H , Keen Chao S , Atz K , Mostinski Y , Topp A , Heer D , Kaufmann I , Ritter M , Gobbi L , Hornsperger B , Wagner B , Richter H , O'Hara F , Wittwer MB , Jul Hansen D , Collin L , Kuhn B , Benz J , Grether U , Nazare M |
Ref : Chembiochem , :e202400704 , 2024 |
Abstract : |
PubMedSearch : Gazzi_2024_Chembiochem__e202400704 |
PubMedID: 39607084 |
Gene_locus related to this paper: human-MGLL |
Title : Identification of (R)-[(18)F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development - He_2023_J.Nucl.Med__ |
Author(s) : He Y , Kramer SD , Grether U , Wittwer MB , Collin L , Kuhn B , Topp A , Heer D , O'Hara F , Honer M , Pavlovic A , Richter H , Ritter M , Rombach D , Keller C , Gobbi L , Mu L |
Ref : J Nucl Med , : , 2023 |
Abstract : |
PubMedSearch : He_2023_J.Nucl.Med__ |
PubMedID: 38164615 |
Title : Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain - He_2022_Eur.J.Med.Chem_243_114750 |
Author(s) : He Y , Grether U , Taddio MF , Meier C , Keller C , Edelmann MR , Honer M , Huber S , Wittwer MB , Heer D , Richter H , Collin L , Hug MN , Hilbert M , Postmus AGJ , Stevens AF , van der Stelt M , Kramer SD , Schibli R , Mu L , Gobbi LC |
Ref : Eur Journal of Medicinal Chemistry , 243 :114750 , 2022 |
Abstract : |
PubMedSearch : He_2022_Eur.J.Med.Chem_243_114750 |
PubMedID: 36137365 |
Gene_locus related to this paper: human-MGLL , mouse-MGLL |
Title : Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold - He_2022_Nucl.Med.Biol_108-109_24 |
Author(s) : He Y , Gobbi LC , Herde AM , Rombach D , Ritter M , Kuhn B , Wittwer MB , Heer D , Hornsperger B , Bell C , O'Hara F , Benz J , Honer M , Keller C , Collin L , Richter H , Schibli R , Grether U , Mu L |
Ref : Nucl Med Biol , 108-109 :24 , 2022 |
Abstract : |
PubMedSearch : He_2022_Nucl.Med.Biol_108-109_24 |
PubMedID: 35248850 |
Gene_locus related to this paper: human-MGLL |
Title : A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature - Kemble_2022_PLoS.One_17_e0268590 |
Author(s) : Kemble AM , Hornsperger B , Ruf I , Richter H , Benz J , Kuhn B , Heer D , Wittwer M , Engelhardt B , Grether U , Collin L |
Ref : PLoS ONE , 17 :e0268590 , 2022 |
Abstract : |
PubMedSearch : Kemble_2022_PLoS.One_17_e0268590 |
PubMedID: 36084029 |
Gene_locus related to this paper: human-MGLL |