Valant C

General

Full name : Valant Celine

First name : Celine

Mail : Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052

Zip Code :

City :

Country : Australia

Email : celine.valant@monash.edu

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Comment

References (9)

Title : Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M(1) muscarinic acetylcholine receptor - Keov_2013_Mol.Pharmacol_84_425
Author(s) : Keov P , Valant C , Devine SM , Lane JR , Scammells PJ , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 84 :425 , 2013
Abstract :
PubMedSearch : Keov_2013_Mol.Pharmacol_84_425
PubMedID: 23798605

Title : Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs - Dror_2013_Nature_503_295
Author(s) : Dror RO , Green HF , Valant C , Borhani DW , Valcourt JR , Pan AC , Arlow DH , Canals M , Lane JR , Rahmani R , Baell JB , Sexton PM , Christopoulos A , Shaw DE
Ref : Nature , 503 :295 , 2013
Abstract :
PubMedSearch : Dror_2013_Nature_503_295
PubMedID: 24121438

Title : Activation and allosteric modulation of a muscarinic acetylcholine receptor - Kruse_2013_Nature_504_101
Author(s) : Kruse AC , Ring AM , Manglik A , Hu J , Hu K , Eitel K , Hubner H , Pardon E , Valant C , Sexton PM , Christopoulos A , Felder CC , Gmeiner P , Steyaert J , Weis WI , Garcia KC , Wess J , Kobilka BK
Ref : Nature , 504 :101 , 2013
Abstract :
PubMedSearch : Kruse_2013_Nature_504_101
PubMedID: 24256733

Title : Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor - Mistry_2013_J.Med.Chem_56_5151
Author(s) : Mistry SN , Valant C , Sexton PM , Capuano B , Christopoulos A , Scammells PJ
Ref : Journal of Medicinal Chemistry , 56 :5151 , 2013
Abstract :
PubMedSearch : Mistry_2013_J.Med.Chem_56_5151
PubMedID: 23718562

Title : Probing structural requirements of positive allosteric modulators of the m4 muscarinic receptor - Huynh_2013_J.Med.Chem_56_8196
Author(s) : Huynh T , Valant C , Crosby IT , Sexton PM , Christopoulos A , Capuano B
Ref : Journal of Medicinal Chemistry , 56 :8196 , 2013
Abstract :
PubMedSearch : Huynh_2013_J.Med.Chem_56_8196
PubMedID: 24074052

Title : Allosteric modulation of endogenous metabolites as an avenue for drug discovery - Wootten_2012_Mol.Pharmacol_82_281
Author(s) : Wootten D , Savage EE , Valant C , May LT , Sloop KW , Ficorilli J , Showalter AD , Willard FS , Christopoulos A , Sexton PM
Ref : Molecular Pharmacology , 82 :281 , 2012
Abstract :
PubMedSearch : Wootten_2012_Mol.Pharmacol_82_281
PubMedID: 22576254

Title : Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects - Valant_2012_Mol.Pharmacol_81_41
Author(s) : Valant C , Felder CC , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 81 :41 , 2012
Abstract :
PubMedSearch : Valant_2012_Mol.Pharmacol_81_41
PubMedID: 21989256

Title : Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity - Stewart_2009_J.Pharmacol.Exp.Ther_331_277
Author(s) : Stewart GD , Valant C , Dowell SJ , Mijaljica D , Devenish RJ , Scammells PJ , Sexton PM , Christopoulos A
Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :277 , 2009
Abstract :
PubMedSearch : Stewart_2009_J.Pharmacol.Exp.Ther_331_277
PubMedID: 19641164

Title : A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric\/allosteric ligand - Valant_2008_J.Biol.Chem_283_29312
Author(s) : Valant C , Gregory KJ , Hall NE , Scammells PJ , Lew MJ , Sexton PM , Christopoulos A
Ref : Journal of Biological Chemistry , 283 :29312 , 2008
Abstract :
PubMedSearch : Valant_2008_J.Biol.Chem_283_29312
PubMedID: 18723515