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| Title : Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models - Digby_2012_J.Neurosci_32_8532 |
| Author(s) : Digby GJ , Noetzel MJ , Bubser M , Utley TJ , Walker AG , Byun NE , LeBois EP , Xiang Z , Sheffler DJ , Cho HP , Davis AA , Nemirovsky NE , Mennenga SE , Camp BW , Bimonte-Nelson HA , Bode J , Italiano K , Morrison R , Daniels JS , Niswender CM , Olive MF , Lindsley CW , Jones CK , Conn PJ |
| Ref : Journal of Neuroscience , 32 :8532 , 2012 |
| Abstract : Digby_2012_J.Neurosci_32_8532 |
| ESTHER : Digby_2012_J.Neurosci_32_8532 |
| PubMedSearch : Digby_2012_J.Neurosci_32_8532 |
| PubMedID: 22723693 |
| Title : Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012 - Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| Author(s) : Melancon BJ , Lamers AP , Bridges TM , Sulikowski GA , Utley TJ , Sheffler DJ , Noetzel MJ , Morrison RD , Daniels JS , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1044 , 2012 |
| Abstract : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| ESTHER : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| PubMedSearch : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| PubMedID: 22197142 |
| Title : Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor - Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| Author(s) : Salovich JM , Vinson PN , Sheffler DJ , Lamsal A , Utley TJ , Blobaum AL , Bridges TM , Le U , Jones CK , Wood MR , Daniels JS , Conn PJ , Niswender CM , Lindsley CW , Hopkins CR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :5084 , 2012 |
| Abstract : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| ESTHER : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| PubMedSearch : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| PubMedID: 22738637 |
| Title : Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery - |
| Author(s) : Melancon BJ , Hopkins CR , Wood MR , Emmitte KA , Niswender CM , Christopoulos A , Conn PJ , Lindsley CW |
| Ref : Journal of Medicinal Chemistry , 55 :1445 , 2012 |
| PubMedID: 22148748 |
| Title : The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease - Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| Author(s) : Jones CK , Bubser M , Thompson AD , Dickerson JW , Turle-Lorenzo N , Amalric M , Blobaum AL , Bridges TM , Morrison RD , Jadhav S , Engers DW , Italiano K , Bode J , Daniels JS , Lindsley CW , Hopkins CR , Conn PJ , Niswender CM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :404 , 2012 |
| Abstract : Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| ESTHER : Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| PubMedSearch : Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| PubMedID: 22088953 |
| Title : Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe - Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| Author(s) : Reid PR , Bridges TM , Sheffler DJ , Cho HP , Lewis LM , Days E , Daniels JS , Jones CK , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2697 , 2011 |
| Abstract : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| ESTHER : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| PubMedSearch : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| PubMedID: 21194936 |
| Title : Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system - Lebois_2010_ACS.Chem.Neurosci_1_104 |
| Author(s) : LeBois EP , Bridges TM , Lewis LM , Dawson ES , Kane AS , Xiang Z , Jadhav SB , Yin H , Kennedy JP , Meiler J , Niswender CM , Jones CK , Conn PJ , Weaver CD , Lindsley CW |
| Ref : ACS Chem Neurosci , 1 :104 , 2010 |
| Abstract : Lebois_2010_ACS.Chem.Neurosci_1_104 |
| ESTHER : Lebois_2010_ACS.Chem.Neurosci_1_104 |
| PubMedSearch : Lebois_2010_ACS.Chem.Neurosci_1_104 |
| PubMedID: 21961051 |
| Title : Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe - Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| Author(s) : Weaver CD , Sheffler DJ , Lewis LM , Bridges TM , Williams R , Nalywajko NT , Kennedy JP , Mulder MM , Jadhav S , Aldrich LA , Jones CK , Marlo JE , Niswender CM , Mock MM , Zheng F , Conn PJ , Lindsley CW |
| Ref : Curr Top Med Chem , 9 :1217 , 2009 |
| Abstract : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| ESTHER : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| PubMedSearch : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| PubMedID: 19807667 |
| Title : A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning - Sheffler_2009_Mol.Pharmacol_76_356 |
| Author(s) : Sheffler DJ , Williams R , Bridges TM , Xiang Z , Kane AS , Byun NE , Jadhav S , Mock MM , Zheng F , Lewis LM , Jones CK , Niswender CM , Weaver CD , Lindsley CW , Conn PJ |
| Ref : Molecular Pharmacology , 76 :356 , 2009 |
| Abstract : Sheffler_2009_Mol.Pharmacol_76_356 |
| ESTHER : Sheffler_2009_Mol.Pharmacol_76_356 |
| PubMedSearch : Sheffler_2009_Mol.Pharmacol_76_356 |
| PubMedID: 19407080 |
| Title : Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity - Marlo_2009_Mol.Pharmacol_75_577 |
| Author(s) : Marlo JE , Niswender CM , Days EL , Bridges TM , Xiang Y , Rodriguez AL , Shirey JK , Brady AE , Nalywajko T , Luo Q , Austin CA , Williams MB , Kim K , Williams R , Orton D , Brown HA , Lindsley CW , Weaver CD , Conn PJ |
| Ref : Molecular Pharmacology , 75 :577 , 2009 |
| Abstract : Marlo_2009_Mol.Pharmacol_75_577 |
| ESTHER : Marlo_2009_Mol.Pharmacol_75_577 |
| PubMedSearch : Marlo_2009_Mol.Pharmacol_75_577 |
| PubMedID: 19047481 |
| Title : Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins - Bridges_2009_J.Med.Chem_52_3445 |
| Author(s) : Bridges TM , Marlo JE , Niswender CM , Jones CK , Jadhav SB , Gentry PR , Plumley HC , Weaver CD , Conn PJ , Lindsley CW |
| Ref : Journal of Medicinal Chemistry , 52 :3445 , 2009 |
| Abstract : Bridges_2009_J.Med.Chem_52_3445 |
| ESTHER : Bridges_2009_J.Med.Chem_52_3445 |
| PubMedSearch : Bridges_2009_J.Med.Chem_52_3445 |
| PubMedID: 19438238 |
| Title : An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission - Shirey_2008_Nat.Chem.Biol_4_42 |
| Author(s) : Shirey JK , Xiang Z , Orton D , Brady AE , Johnson KA , Williams R , Ayala JE , Rodriguez AL , Wess J , Weaver D , Niswender CM , Conn PJ |
| Ref : Nat Chemical Biology , 4 :42 , 2008 |
| Abstract : Shirey_2008_Nat.Chem.Biol_4_42 |
| ESTHER : Shirey_2008_Nat.Chem.Biol_4_42 |
| PubMedSearch : Shirey_2008_Nat.Chem.Biol_4_42 |
| PubMedID: 18059262 |