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Fusarinine_C_esterase_sidJ

Relationship

Family: Fusarinine_C_esterase_sidJ

Block: X

Parent Family: No family

Comment

Grundlingern et al. show that Aspergillus fumigatus AFUA_3G03390 gene product, SidJ (aspfu-q4wf56) is involved in hydrolysis of siderophore fusarinine C. It is the first functionally characterized member of the family. Structure of siderophore esterase AfSidJ from Aspergillus fumigatus is described by Ecker et al.. A structure of a protein of unknown fucntion is also available (2Q0X) Merritt et al. . However this protein is only representative of trypanosomatid members of this sequence family as these proteins lack some if not all of the catalytic triad residues. Fusarinine C is an intracellular siderophore (an iron-chelating compound that transports iron across membranes) that is crucial for virulence. The closely related siderophore triacetylfusarinine C is not hydrolysed by SidJ. Homologues of SidJ are found in plants and bacteria. (Not to be cofounded with SidJ Calmodulin-dependent glutamylase from Legionella pneumophila).Previously named DUF_1749

Database

Interpro : IPR013744 Fusarinine C esterase sidJ DUF_1749

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF08538 DUF1749

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
6GUP Aspergillus fumigatus AfSidJ Siderophore fusarinine C hydrolase aspfu-q4wf56
2Q0X Alpha\/beta hydrolase fold protein of unknown function Trypanosoma brucei tryb2-q389w3

Gene_locus Name Species
ajecg-c0nu33 Ajellomyces capsulata (strains G186AR \/ H82 \/ ATCC MYA-2454 \/ RMSC 2432\; NAm1 \/ WU24\; H143\; H88) (Darling's disease fungus) (Histoplasma capsulatum) Dolichol-phosphate mannosyltransferase Ajellomyces capsulata
ajedr-c5g9q3 Ajellomyces dermatitidis (Blastomyces dermatitidis) Esterase Ajellomyces dermatitidis
arath-AT5G19050 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) hypothetical 38.4 kda protein protein at5g19050 Arabidopsis thaliana
artgp-e5qzf5 Arthroderma gypseum (strain ATCC MYA-4604 \/ CBS 118893) (Microsporum gypseum) Dolichol-phosphate mannosyltransferase Arthroderma gypseum
artoc-c5fds1 Arthroderma otae (strain ATCC MYA-4605 \/ CBS 113480) (Microsporum canis) Dolichol-phosphate mannosyltransferase Arthroderma otae
aspcl-a1cc86 Aspergillus clavatus (strain ATCC 1007 \/ CBS 513.65 \/ DSM 816 \/ NCT 3887 \/ NRRL 1) Siderophore biosynthesis lipase\/esterase, putative Aspergillus clavatus
aspcl-a1cke4 Aspergillus clavatus (strain ATCC 1007 \/ CBS 513.65 \/ DSM 816 \/ NCT 3887 \/ NRRL 1) Putative uncharacterized protein Aspergillus clavatus
aspfn-b8n1s7 Aspergillus flavus (strain ATCC 200026 \/ FGSC A1120 \/ NRRL 3357 \/ JC 12722 \/ SRRC 167) Putative uncharacterized protein Aspergillus flavus
aspfu-q4wa78 Aspergillus fumigatus (Sartorya fumigata), Neosartorya fumigata, Neosartorya fischeri (Aspergillus fischerianus), hypothetical protein Aspergillus fumigatus
aspfu-q4wf56 Aspergillus fumigatus (Sartorya fumigata) Neosartorya fumigata, Neosartorya fischeri (Aspergillus fischerianus) AfSidJ Siderophore fusarinine C hydrolase Aspergillus fumigatus
aspfu-q4wxr1 Aspergillus fumigatus (Sartorya fumigata), Neosartorya fumigata, Neosartorya fischeri, (Aspergillus fischerianus), hypothetical protein Aspergillus fumigatus
aspnc-a2qgj6 Aspergillus niger (strain CBS 513.88 \/ FGSC A1513) Similarity: the ORF shows strong similarity to the A. niger protein An16g04320 Aspergillus niger
aspnc-a2r7q1 Aspergillus niger (strain CBS 513.88 \/ FGSC A1513) Putative uncharacterized protein An16g04320 Aspergillus niger
aspor-q2typ0 Aspergillus oryzae. predicted hydrolases or acyltransferases Aspergillus oryzae
aspor-q2u9a1 Aspergillus oryzae (Yellow koji mold), Aspergillus flavus, predicted hydrolases or acyltransferases Aspergillus oryzae
asptn-q0cp11 Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) Dolichol-phosphate mannosyltransferase Aspergillus terreus
asptn-q0cuc2 Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) Putative uncharacterized protein Aspergillus terreus
canal-q5ajt3 Candida albicans (Yeast). hypothetical protein Candida albicans SC5314
candc-b9wdh9 Candida dubliniensis (strain CD36 \/ ATCC MYA-646 \/ CBS 7987 \/ NCP 3949 \/ NRRL Y-17841) (Yeast) Putative uncharacterized protein Candida dubliniensis
canga-q6fxd7 Candida glabrata (Yeast) (Torulopsis glabrata). candida glabrata strain cbs138 chromosome b complete sequence Candida glabrata
cantt-c5ma78 Candida tropicalis (strain ATCC MYA-3404 \/ T1) (Yeast) Putative uncharacterized protein Candida tropicalis
chagb-q2grc8 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2h9y7 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2hct5 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chlre-a8j248 Chlamydomonas reinhardtii (Chlamydomonas smithii) Predicted protein Chlamydomonas reinhardtii
chlva-e1z3j3 Chlorella variabilis (Green alga) Putative uncharacterized protein Chlorella variabilis
chlva-e1z620 Chlorella variabilis (Green alga) Putative uncharacterized protein Chlorella variabilis
clal4-c4xwy4 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein Clavispora lusitaniae
cocps-e9cz73 Coccidioides posadasii (strains RMSCC 757 \/ Silveira\; C735) (Valley fever fungus) Putative uncharacterized protein Coccidioides posadasii
colgm-e3qr27 Colletotrichum graminicola (strain M1.001 \/ M2 \/ FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) Putative uncharacterized protein Colletotrichum graminicola
cryne-q5knq0 Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus) . hypothetical protein Cryptococcus neoformans
cryne-q55zd3 Cryptococcus neoformans var. neoformans B-3501A. hypothetical protein Cryptococcus neoformans var. neoformans B-3501A
debha-b5rtk1 Debaryomyces hansenii (Yeast) (Torulaspora hansenii). similar to ca|ca3999|ipf10447 candida albicans ipf10447 Debaryomyces hansenii
emeni-q5ay37 Emericella nidulans (strain FGSC A4 \/ ATCC 38163 \/ CBS 112.46 \/ NRR 194 \/ M139) (Aspergillus nidulans) Esterase, putative (AFU_orthologue\; AFUA_7G00330) Emericella nidulans
emeni-q5azp1 Emericella nidulans (strain FGSC A4 \/ ATCC 38163 \/ CBS 112.46 \/ NRR 194 \/ M139) (Aspergillus nidulans) Siderophore biosynthesis lipase\/esterase, putative (AFU_orthologue\; AFUA_3G03390) Aspergillus nidulans FGSC A4
emeni-q5b3d2 Aspergillus nidulans FGSC A4. hypothetical protein Aspergillus nidulans FGSC A4
enccu-q8sut7 Encephalitozoon cuniculi. hypothetical protein ecu08_0180 Encephalitozoon cuniculi
encit-e0s8f3 Encephalitozoon intestinalis (strain ATCC 50506) (Microsporidian parasite) (Septata intestinalis) Putative uncharacterized protein Encephalitozoon intestinalis
entbh-b7xjm2 Enterocytozoon bieneusi (strain H348) (Microsporidian parasite) Hydrolase (Alpha\/beta hydrolase superfamily), predicted Enterocytozoon bieneusi
enthi-c4mb48 Entamoeba histolytica Putative uncharacterized protein Entamoeba histolytica
gibze-q4ib36 Gibberella zeae (Fusarium graminearum). hypothetical protein Gibberella zeae
grocl-f0xc51 Grosmannia clavigera (strain kw1407 \/ UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera) Duf1749 domain containing protein Grosmannia clavigera
klula-q6ckd7 Kluyveromyces lactis (Yeast). protein Kluyveromyces lactis
lactc-c5dez1 Lachancea thermotolerans (strain ATCC 56472 \/ CBS 6340 \/ NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) KLTH0D10912p Lachancea thermotolerans
leibr-a4hpz5 Leishmania braziliensis Putative uncharacterized protein Leishmania braziliensis
leima-q4q0t5 Leishmania major, Leishmania infantum, Leishmania donovani, hypothetical protein Leishmania major
leimu-e9atr2 Leishmania mexicana (strain MHOM\/GT\/2001\/U1103) Putative uncharacterized protein Leishmania mexicana
lepmj-e5a510 Leptosphaeria maculans (strain JN3 \/ isolate v23.1.3 \/ rac Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam) Putative uncharacterized protein Leptosphaeria maculans
lodel-a5e1c1 Lodderomyces elongisporus (strain ATCC 11503 \/ CBS 2605 \/ JCM 1781 \/ NBRC 1676 \/ NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) Putative uncharacterized protein Lodderomyces elongisporus
maize-c0pa79 Zea mays (Maize) Uncharacterized protein Zea mays
malgo-a8pwr6 Malassezia globosa (strain ATCC MYA-4612 \/ CBS 7966) (Dandruff-associated fungus) Putative uncharacterized protein Malassezia globosa
metaq-e9dy00 Metarhizium acridum, Metarhizium robertsii (Metarhizium anisopliae) Esterase\/lipase Metarhizium acridum
micpc-c1msr1 Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga) Predicted protein Micromonas pusilla
nech7-c7yym7 Nectria haematococca (strain 77-13-4 \/ ATCC MYA-4622 \/ FGSC 9596 MPVI) (Fusarium solani subsp. pisi) Putative uncharacterized protein Nectria haematococca
neocl-f0vce2 Neospora caninum (strain Liverpool) Predicted hydrolases or acyltransferases,related Neospora caninum
neucr-q7rzk2 Neurospora crassa. hypothetical protein Neurospora crassa
nosce-c4v7s6 Nosema ceranae (strain BRL01) (Microsporidian parasite) Putative uncharacterized protein Nosema ceranae
orysa-Q7F1B1 Oryza sativa subsp. japonica subsp. indica (Rice) OJ1664_D08.103-1 osjnbb0042j07.10-1) protein Oryza sativa
ostlu-a4rut7 Ostreococcus lucimarinus (strain CCE9901) Predicted protein Ostreococcus lucimarinus
ostta-q01ca2 Ostreococcus tauri Predicted hydrolases or acyltransferases (Alpha\/beta hydrolase superfamily) (ISS) Ostreococcus tauri
parbd-c1g110 Paracoccidioides brasiliensis (strains Pb18\; Pb03\; ATCC MYA-826 \/ Pb01) Putative uncharacterized protein Paracoccidioides brasiliensis
pencw-b6h2f4 Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Pc13g05160 protein Penicillium chrysogenum
pencw-b6h4s6 Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Pc13g10260 protein Penicillium chrysogenum
pencw-b6hqu4 Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Pc22g20410 protein Penicillium chrysogenum
penmq-b6q3x2 Penicillium marneffei (strain ATCC 18224 \/ CBS 334.59 \/ QM 7333) Putative uncharacterized protein Penicillium marneffei
penmq-b6qsw7 Penicillium marneffei (strain ATCC 18224 \/ CBS 334.59 \/ QM 7333) Siderophore biosynthesis lipase\/esterase, putative Penicillium marneffei
perm5-c5k521 Perkinsus marinus (strain ATCC 50983 \/ TXsc) Putative uncharacterized protein Perkinsus marinus
phano-q0udp4 Phaeosphaeria nodorum (strain SN15 \/ ATCC MYA-4574 \/ FGSC 10173) (Glume blotch fungus) (Septoria nodorum) Putative uncharacterized protein Phaeosphaeria nodorum
phatc-b7gb22 Phaeodactylum tricornutum (strain CCAP 1055\/1) Predicted protein Phaeodactylum tricornutum
phypa-a9t9c9 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
picad-e7r6i8 Pichia angusta (strain ATCC 26012 \/ NRRL Y-7560 \/ DL-1) (Yeast) (Hansenula polymorpha) Putative uncharacterized protein Pichia angusta
picad-e7raw7 Pichia angusta (strain ATCC 26012 \/ NRRL Y-7560 \/ DL-1) (Yeast) (Hansenula polymorpha) Putative uncharacterized protein Pichia angusta
picgu-a5dbk0 Meyerozyma guilliermondii (strain ATCC 6260 \/ CBS 566 \/ DSM 6381 \/ JC 1539 \/ NBRC 10279 \/ NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein Meyerozyma guilliermondii
picp7-f2qwe3 Pichia pastoris (Yeast) UPF0613 protein PB24D3.06c Pichia pastoris
picsi-d5aba5 Picea sitchensis (Sitka spruce) (Pinus sitchensis) Putative uncharacterized protein Picea sitchensis
picst-a3gha8 Scheffersomyces stipitis (strain ATCC 58785 \/ CBS 6054 \/ NBRC 10063 \/ NRRL Y-11545) (Yeast) (Pichia stipitis) Predicted protein Scheffersomyces stipitis
podan-b2a9k6 Podospora anserina (strain S \/ ATCC MYA-4624 \/ DSM 980 \/ FGSC 10383) (Pleurage anserina) Predicted CDS Pa_1_80 Podospora anserina
podan-b2avx3 Podospora anserina (strain S \/ ATCC MYA-4624 \/ DSM 980 \/ FGSC 10383) (Pleurage anserina) Predicted CDS Pa_7_5190 Podospora anserina
poptr-b9hmd0 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Predicted protein Populus trichocarpa
pucgt-e3kaq6 Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 \/ race SCCL) (Black stem rust fungus) Putative uncharacterized protein Puccinia graminis f. sp. tritici
pyrtr-b2wiv3 Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) Putative uncharacterized protein Pyrenophora tritici-repentis
pyrtt-e3rkr9 Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres) Putative uncharacterized protein Pyrenophora teres f. teres
ricco-b9rtt3 Ricinus communis (Castor bean) Catalytic, putative Ricinus communis
schpo-q9c0y8 Schizosaccharomyces pombe (Fission yeast). spapb24d3.06c protein Schizosaccharomyces pombe
scls1-a7emm0 Sclerotinia sclerotiorum (strain ATCC 18683 \/ 1980 \/ Ss-1) (White mold) (Whetzelinia sclerotiorum) Putative uncharacterized protein Sclerotinia sclerotiorum
scls1-a7f208 Sclerotinia sclerotiorum (strain ATCC 18683 \/ 1980 \/ Ss-1) (White mold) (Whetzelinia sclerotiorum) Putative uncharacterized protein Sclerotinia sclerotiorum
selml-d8rbs1 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
soybn-c6tiz7 Glycine max (Soybean) (Glycine hispida) Uncharacterized protein Glycine max
spore-e6zz09 Sporisorium reilianum (strain SRZ2) (Maize head smut fungus) Putative uncharacterized protein Sporisorium reilianum
talsn-b8m7k7 Talaromyces stipitatus (strain ATCC 10500 \/ CBS 375.48 \/ QM 6759 \/ NRRL 1006) (Penicillium stipitatum) Putative uncharacterized protein Talaromyces stipitatus
talsn-b8mmn2 Talaromyces stipitatus (strain ATCC 10500 \/ CBS 375.48 \/ QM 6759 \/ NRRL 1006) (Penicillium stipitatum) Siderophore biosynthesis lipase\/esterase, putative Talaromyces stipitatus
toxgo-b6kvv5 Toxoplasma gondii Putative uncharacterized protein Toxoplasma gondii
trirc-f2sf42 Trichophyton rubrum (strain ATCC MYA-4607 \/ CBS 118892) (Athlete's foot fungus) Putative uncharacterized protein Trichophyton rubrum
trivh-d4dbr9 Trichophyton verrucosum, Arthroderma benhamiae (T. mentagrophytes), T. tonsurans (Scalp ringworm fungus), T. equinum (Horse ringworm fungus) Esterase, putative Trichophyton verrucosum
tryb2-q389w3 Trypanosoma brucei hypothetical protein Trypanosoma brucei
trycr-q4dry8 Trypanosoma cruzi. hypothetical protein Trypanosoma cruzi
tubmm-d5g5r5 Tuber melanosporum (strain Mel28) (Perigord black truffle) Whole genome shotgun sequence assembly, scaffold_112, strain Mel28 Tuber melanosporum
uncre-c4jyw9 Uncinocarpus reesii (strain UAMH 1704) Putative uncharacterized protein Uncinocarpus reesii
vanpo-a7tkp1 Vanderwaltozyma polyspora (strain ATCC 22028 \/ DSM 70294) (Kluyveromyces polysporus) Putative uncharacterized protein Vanderwaltozyma polyspora
vera1-c9spy5 Verticillium albo-atrum (strain VaMs.102 \/ ATCC MYA-4576 \/ FGSC 10136) (Verticillium wilt) Putative uncharacterized protein Verticillium albo-atrum
vera1-c9srn8 Verticillium albo-atrum (strain VaMs.102 \/ ATCC MYA-4576 \/ FGSC 10136) (Verticillium wilt) Putative uncharacterized protein Verticillium albo-atrum
volca-d8uiw9 Volvox carteri (Green alga) Putative uncharacterized protein Volvox carteri
yarli-q6c6p7 Yarrowia lipolytica (Candida lipolytica). similar to deha0d18975g debaryomyces hansenii Yarrowia lipolytica
zygrc-c5dxq9 Zygosaccharomyces rouxii (strain ATCC 2623 \/ CBS 732 \/ NBRC 1130 \/ NCYC 568 \/ NRRL Y-229) (Candida mogii) ZYRO0F07040p Zygosaccharomyces rouxii

Gene_locus_frgt Name Species
actpl-e0eyn8 Actinobacillus pleuropneumoniae Putative uncharacterized protein Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261
phano-q0ucs3 Phaeosphaeria nodorum (strain SN15 \/ ATCC MYA-4574 \/ FGSC 10173) (Glume blotch fungus) (Septoria nodorum) Putative uncharacterized protein Phaeosphaeria nodorum
thaps-b8c6f2 Thalassiosira pseudonana (Marine diatom) (Cyclotella nana) Predicted protein Thalassiosira pseudonana
vitvi-a5bhc3 Vitis vinifera (Grape) Putative uncharacterized protein Vitis vinifera

Substrate Chemical Nomenclature Proteins
Fusigen iron(3+)\;(9Z,21Z,33Z)-3,15,27-triamino-10,22,34-trimethyl-7,19,31-trioxido-1,13,25-trioxa-7,19,31-triazacyclohexatriaconta-9,21,33-triene-2,8,14,20,26,32-hexone aspfu-q4wf56

References (3)

Title : Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases - Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624
Author(s) : Ecker F , Haas H , Groll M , Huber EM
Ref : Angew Chem Int Ed Engl , 57 :14624 , 2018
Abstract :
PubMedSearch : Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624
PubMedID: 30070018
Gene_locus related to this paper: aspfu-q4wf29 , emeni-AnEstB , emeni-q5av79 , aspfu-q4wf56

Title : Aspergillus fumigatus SidJ Mediates Intracellular Siderophore Hydrolysis - Grundlinger_2013_Appl.Environ.Microbiol_79_7534
Author(s) : Grundlinger M , Gsaller F , Schrettl M , Lindner H , Haas H
Ref : Applied Environmental Microbiology , 79 :7534 , 2013
Abstract :
PubMedSearch : Grundlinger_2013_Appl.Environ.Microbiol_79_7534
PubMedID: 24038704
Gene_locus related to this paper: aspfu-q4wf56

Title : Structure of a Trypanosoma brucei alpha\/beta-hydrolase fold protein with unknown function - Merritt_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_474
Author(s) : Merritt EA , Holmes M , Buckner FS , Van Voorhis WC , Quartly E , Phizicky EM , Lauricella A , Luft J , DeTitta G , Neely H , Zucker F , Hol WG
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 64 :474 , 2008
Abstract :
PubMedSearch : Merritt_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_474
PubMedID: 18540054
Gene_locus related to this paper: tryb2-q389w3