(The family Pha_synthase was split in four families (PHA_synth_I, PHA_synth_II, PHA_synth_III, PhaC_cen_dom ) according to Interpro and Tigrpfam PhaC_cen_dom groups enzyme with the central domain but not the class I,II,III domains). This entry represents the class II subfamily of poly(R)-hydroxyalkanoate synthases, which polymerises hydroxyacyl-CoAs, typically with six to fourteen carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids. These polymers accumulate as carbon and energy storage inclusions in many species and can amount to 90 percent of the dry weight of cell. Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus. This entry represents the central domain of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulphur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond. PHA_synth_I TIGR01838 PHA_synth_II TIGR01839. The nucleophilic residue of the catalytic triad is a cysteine (with exceptions)
Interpro : IPR010941 PhaC_cen_dom Poly-beta-hydroxybutyrate polymerase, central domain , IPR011287 Poly(R)-hydroxyalkanoic acid synthase, class II
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF07167 PhaC_N
Prints : No Print
EC Number : No EC Number
No structure scheme yet for this family
Genes Proteins in PHA_synth_II family (37)
No fragment of genes
No fragment of genesSubstrates in PHA_synth_II family (3)
No Inhibitor
Title : Polyhydroxyalkanoate synthase (PhaC): The key enzyme for biopolyester synthesis - Neoh_2022_Curr.Res.Biotechnol_4_87 |
Author(s) : Neoh SZ , Chek MF , Tan HT , Linares-Pasten JA , Nandakumar A , Hakoshima T , Sudesh K |
Ref : Current Research in Biotechnology , 4 :87 , 2022 |
Abstract : Neoh_2022_Curr.Res.Biotechnol_4_87 |
ESTHER : Neoh_2022_Curr.Res.Biotechnol_4_87 |
PubMedSearch : Neoh_2022_Curr.Res.Biotechnol_4_87 |
PubMedID: |
Title : Polyester synthases: natural catalysts for plastics - Rehm_2003_Biochem.J_376_15 |
Author(s) : Rehm BH |
Ref : Biochemical Journal , 376 :15 , 2003 |
Abstract : Rehm_2003_Biochem.J_376_15 |
ESTHER : Rehm_2003_Biochem.J_376_15 |
PubMedSearch : Rehm_2003_Biochem.J_376_15 |
PubMedID: 12954080 |
Title : PhaC and PhaR are required for polyhydroxyalkanoic acid synthase activity in Bacillus megaterium - McCool_2001_J.Bacteriol_183_4235 |
Author(s) : McCool GJ , Cannon MC |
Ref : Journal of Bacteriology , 183 :4235 , 2001 |
Abstract : McCool_2001_J.Bacteriol_183_4235 |
ESTHER : McCool_2001_J.Bacteriol_183_4235 |
PubMedSearch : McCool_2001_J.Bacteriol_183_4235 |
PubMedID: 11418564 |
Gene_locus related to this paper: bacme-PHAC |
Title : Cloning, molecular analysis, and expression of the polyhydroxyalkanoic acid synthase (phaC) gene from Chromobacterium violaceum - Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
Author(s) : Kolibachuk D , Miller A , Dennis D |
Ref : Applied Environmental Microbiology , 65 :3561 , 1999 |
Abstract : Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
ESTHER : Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
PubMedSearch : Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
PubMedID: 10427049 |
Gene_locus related to this paper: chrvi-PHAC , vibpa-PHAC |