3-hydroxybutyrate
Monomer and product of hydrolysis of poly(3-hydroxybutyrate) (PHB), and poly-hydroxybutyrate-co-hydroxyvalerate biodegradable polymers. Monomers for the synthesis by poly(3-hydroxyalkanoate) polymerase subunit phac. PhaC uses 3HB-CoA as substrate and a PHB chain to add monomers
General
Type : Butyrate
Chemical_Nomenclature :
Canonical SMILES : CC(CC(=O)[O-])O || CC(CC(=O)O)O
InChI : InChI=1S\/C4H8O3\/c1-3(5)2-4(6)7\/h3,5H,2H2,1H3,(H,6,7)\/p-1 || InChI=1S\/C4H8O3\/c1-3(5)2-4(6)7\/h3,5H,2H2,1H3,(H,6,7)
InChIKey : WHBMMWSBFZVSSR-UHFFFAOYSA-M || WHBMMWSBFZVSSR-UHFFFAOYSA-N
Other name(s) : 3HB || 3-hydroxybutyrate || 3-hydroxybutanoate || beta-hydroxybutyrate || beta-hydroxybutanoate || R-3HB || FG2UN5EP9V || 3-hydroxybutyric acid || 3-hydroxybutanoic acid || Butanoic acid, 3-hydroxy-
MW : 103.10
Formula : C4H7O3-
CAS_number : 300-85-6, 625-71-8
UniChem : WHBMMWSBFZVSSR-UHFFFAOYSA-M, WHBMMWSBFZVSSR-UHFFFAOYSA-N
Target
Structures : No structure
Families : PHA_synth_I, PHA_synth_III_C, PHA_synth_II
References (15)
| Title : A review on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] and genetic modifications that affect its production - Tang_2022_Front.Bioeng.Biotechnol_10_1057067 |
| Author(s) : Tang HJ , Neoh SZ , Sudesh K |
| Ref : Front Bioeng Biotechnol , 10 :1057067 , 2022 |
| Abstract : |
| PubMedSearch : Tang_2022_Front.Bioeng.Biotechnol_10_1057067 |
| PubMedID: 36545679 |
| Title : Engineering Pseudomonas entomophila for synthesis of copolymers with defined fractions of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates - Li_2019_Metab.Eng_52_253 |
| Author(s) : Li M , Chen X , Che X , Zhang H , Wu LP , Du H , Chen GQ |
| Ref : Metab Eng , 52 :253 , 2019 |
| Abstract : |
| PubMedSearch : Li_2019_Metab.Eng_52_253 |
| PubMedID: 30582985 |
| Title : Identification and Analysis of Putative Polyhydroxyalkanoate Synthase (PhaC) in Pseudomonas fluorescens - Lim_2018_J.Microbiol.Biotechnol_28_1133 |
| Author(s) : Lim JH , Rhie HG , Kim JN |
| Ref : J Microbiol Biotechnol , 28 :1133 , 2018 |
| Abstract : |
| PubMedSearch : Lim_2018_J.Microbiol.Biotechnol_28_1133 |
| PubMedID: 29926705 |
| Gene_locus related to this paper: psefl-q6xh00 |
| Title : Production of poly(3-hydroxypropionate) and poly(3-hydroxybutyrate-co-3-hydroxypropionate) from glucose by engineering Escherichia coli - Meng_2015_Metab.Eng_29_189 |
| Author(s) : Meng DC , Wang Y , Wu LP , Shen R , Chen JC , Wu Q , Chen GQ |
| Ref : Metab Eng , 29 :189 , 2015 |
| Abstract : |
| PubMedSearch : Meng_2015_Metab.Eng_29_189 |
| PubMedID: 25842374 |
| Gene_locus related to this paper: alceu-phbc |
| Title : Compositional regulation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by replacement of granule-associated protein in Ralstonia eutropha - Kawashima_2015_Microb.Cell.Fact_14_187 |
| Author(s) : Kawashima Y , Orita I , Nakamura S , Fukui T |
| Ref : Microb Cell Fact , 14 :187 , 2015 |
| Abstract : |
| PubMedSearch : Kawashima_2015_Microb.Cell.Fact_14_187 |
| PubMedID: 26597300 |
| Gene_locus related to this paper: alceu-phbc |
| Title : A common active site of polyhydroxyalkanoate synthase from Bacillus cereus YB-4 is involved in polymerization and alcoholysis reactions - Hyakutake_2015_Appl.Microbiol.Biotechnol_99_4701 |
| Author(s) : Hyakutake M , Tomizawa S , Mizuno K , Hisano T , Abe H , Tsuge T |
| Ref : Applied Microbiology & Biotechnology , 99 :4701 , 2015 |
| Abstract : |
| PubMedSearch : Hyakutake_2015_Appl.Microbiol.Biotechnol_99_4701 |
| PubMedID: 25503319 |
| Gene_locus related to this paper: bacce-PHAC |
| Title : Class IV polyhydroxyalkanoate (PHA) synthases and PHA-producing Bacillus - Tsuge_2015_Appl.Microbiol.Biotechnol_99_6231 |
| Author(s) : Tsuge T , Hyakutake M , Mizuno K |
| Ref : Applied Microbiology & Biotechnology , 99 :6231 , 2015 |
| Abstract : |
| PubMedSearch : Tsuge_2015_Appl.Microbiol.Biotechnol_99_6231 |
| PubMedID: 26135986 |
| Title : Metabolic engineering of Ralstonia eutropha for the biosynthesis of 2-hydroxyacid-containing polyhydroxyalkanoates - Park_2013_Metab.Eng_20_20 |
| Author(s) : Park SJ , Jang YA , Lee H , Park AR , Yang JE , Shin J , Oh YH , Song BK , Jegal J , Lee SH , Lee SY |
| Ref : Metab Eng , 20 :20 , 2013 |
| Abstract : |
| PubMedSearch : Park_2013_Metab.Eng_20_20 |
| PubMedID: 23973656 |
| Title : Revelation of the ability of Burkholderia sp. USM (JCM 15050) PHA synthase to polymerize 4-hydroxybutyrate monomer - Lau_2012_AMB.Express_2_41 |
| Author(s) : Lau NS , Sudesh K |
| Ref : AMB Express , 2 :41 , 2012 |
| Abstract : |
| PubMedSearch : Lau_2012_AMB.Express_2_41 |
| PubMedID: 22877240 |
| Gene_locus related to this paper: 9neis-e1apk1 |
| Title : Hydroxybutyrate prevents protein aggregation in the halotolerant bacterium Pseudomonas sp. CT13 under abiotic stress - Soto_2012_Extremophiles_16_455 |
| Author(s) : Soto G , Setten L , Lisi C , Maurelis C , Mozzicafreddo M , Cuccioloni M , Angeletti M , Ayub ND |
| Ref : Extremophiles , 16 :455 , 2012 |
| Abstract : |
| PubMedSearch : Soto_2012_Extremophiles_16_455 |
| PubMedID: 22527039 |
| Title : Construction of pha-operon-defined knockout mutants of Pseudomonas putida KT2442 and their applications in poly(hydroxyalkanoate) production - Ouyang_2007_Macromol.Biosci_7_227 |
| Author(s) : Ouyang SP , Liu Q , Fang L , Chen GQ |
| Ref : Macromol Biosci , 7 :227 , 2007 |
| Abstract : |
| PubMedSearch : Ouyang_2007_Macromol.Biosci_7_227 |
| PubMedID: 17295412 |
| Title : Molecular cloning and functional analysis of two polyhydroxyalkanoate synthases from two strains of Aeromonas hydrophila spp - Lu_2005_FEMS.Microbiol.Lett_243_149 |
| Author(s) : Lu X , Zhang W , Jian J , Wu Q , Chen GQ |
| Ref : FEMS Microbiology Letters , 243 :149 , 2005 |
| Abstract : |
| PubMedSearch : Lu_2005_FEMS.Microbiol.Lett_243_149 |
| PubMedID: 15668013 |
| Gene_locus related to this paper: aerhy-PHAC |
| Title : Polyhydroxyalkanoate (PHA) accumulation in sulfate-reducing bacteria and identification of a class III PHA synthase (PhaEC) in Desulfococcus multivorans - Hai_2004_Appl.Environ.Microbiol_70_4440 |
| Author(s) : Hai T , Lange D , Rabus R , Steinbuchel A |
| Ref : Applied Environmental Microbiology , 70 :4440 , 2004 |
| Abstract : |
| PubMedSearch : Hai_2004_Appl.Environ.Microbiol_70_4440 |
| PubMedID: 15294771 |
| Gene_locus related to this paper: desml-phaCDm |
| Title : Engineering of Ralstonia eutropha for production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from fructose and solid-state properties of the copolymer - Fukui_2002_Biomacromolecules_3_618 |
| Author(s) : Fukui T , Abe H , Doi Y |
| Ref : Biomacromolecules , 3 :618 , 2002 |
| Abstract : |
| PubMedSearch : Fukui_2002_Biomacromolecules_3_618 |
| PubMedID: 12005535 |
| Title : Identification of the intracellular polyhydroxyalkanoate depolymerase gene of Paracoccus denitrificans and some properties of the gene product - Gao_2001_FEMS.Microbiol.Lett_196_159 |
| Author(s) : Gao D , Maehara A , Yamane T , Ueda S |
| Ref : FEMS Microbiology Letters , 196 :159 , 2001 |
| Abstract : |
| PubMedSearch : Gao_2001_FEMS.Microbiol.Lett_196_159 |
| PubMedID: 11267773 |
| Gene_locus related to this paper: parde-Q9WX79 |