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Family Report for: PlaB


Family PlaB
Block X
Parent Family : Abhydrolase_6

Bacterial phospholipases. Legionella pneumophila possesses a major cell-associated hemolytic phospholipase A (PlaB) which shares no homology to described phospholipases. PlaB preferentially hydrolyzes long-chain fatty acid substrates containing 12 or more carbon atoms. PlaB shows concentration-dependent phospholipase inactivation by tetramerization which may be a mechanism for self-protection. See Papers: Bender et al. 2009 and Kuhle et al. 2014. The tetramer is a dimer of identical dimers. Diwo et al. found in the structure eight NAD(H) molecules at the dimer/dimerinterface, suggesting that these molecules stabilize the tetramer leading to enzyme inactivation.

PF12697 (Abhydrolase_6)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

1 more
    Title: A phospholipase B from Pseudomonas aeruginosa with activity towards endogenous phospholipids affects biofilm assembly
    Weiler AJ, Spitz O, Gudzuhn M, Schott-Verdugo SN, Kamel M, Thiele B, Streit WR, Kedrov A, Schmitt L and Gohlke H <2 more author(s)>
    Ref: Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids, 1867:159101, 2022 : PubMed


    Title: NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB
    Diwo M, Michel W, Aurass P, Kuhle-Keindorf K, Pippel J, Krausze J, Wamp S, Lang C, Blankenfeldt W, Flieger A
    Ref: Proc Natl Acad Sci U S A, 118:, 2021 : PubMed


    Title: Oligomerization Inhibits Legionella pneumophila PlaB Phospholipase A Activity
    Kuhle K, Krausze J, Curth U, Rossle M, Heuner K, Lang C, Flieger A
    Ref: Journal of Biological Chemistry, 289:18657, 2014 : PubMed


Other Papers

No structure scheme yet for this family

Structures in PlaB family (2)

Genes Proteins in PlaB family (31)

Fragments of genes in PlaB family (2)

Substrates of some enzymes in the PlaB family (4)

Inhibitors of some enzymes in the PlaB family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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