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Family Report for: PlaB

PlaB



Relationship
Family PlaB
Block X
Parent Family : Abhydrolase_6

Comment
Bacterial phospholipases. Legionella pneumophila possesses a major cell-associated hemolytic phospholipase A (PlaB) which shares no homology to described phospholipases. PlaB preferentially hydrolyzes long-chain fatty acid substrates containing 12 or more carbon atoms. PlaB shows concentration-dependent phospholipase inactivation by tetramerization which may be a mechanism for self-protection. See Papers Bender et al. 2009 and Kuhle et al. 2014 The tetramer is a dimer of identical dimers. Diwo et al. found in the structure eight NAD(H) molecules at the dimer/dimerinterface, suggesting that these molecules stabilize the tetramer leading to enzyme inactivation

Database
Sequences
Interpro
|
PIRSF
|
Pdoc
|
PFam
|
PF12697 (Abhydrolase_6)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
1 more
    Title: A phospholipase B from Pseudomonas aeruginosa with activity towards endogenous phospholipids affects biofilm assembly
    Weiler AJ, Spitz O, Gudzuhn M, Schott-Verdugo SN, Kamel M, Thiele B, Streit WR, Kedrov A, Schmitt L and Gohlke H <2 more author(s)>
    Ref: Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids, 1867:159101, 2022 : PubMed

            

    Title: NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB
    Diwo M, Michel W, Aurass P, Kuhle-Keindorf K, Pippel J, Krausze J, Wamp S, Lang C, Blankenfeldt W, Flieger A
    Ref: Proc Natl Acad Sci U S A, 118:, 2021 : PubMed

            

    Title: Oligomerization Inhibits Legionella pneumophila PlaB Phospholipase A Activity
    Kuhle K, Krausze J, Curth U, Rossle M, Heuner K, Lang C, Flieger A
    Ref: Journal of Biological Chemistry, 289:18657, 2014 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in PlaB family (2)

Genes Proteins in PlaB family (31)

Fragments of genes in PlaB family (2)

Substrates of some enzymes in the PlaB family (4)

Inhibitors of some enzymes in the PlaB family (1)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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