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Family Report for: Cutinase

Cutinase



Relationship
Family Cutinase
Block X
Parent Family : Cutinase_like

Comment
This family corresponds to the Carbohydrate Esterase family CE5 in CAZy - Carbohydrate-Active enZYmes database (CE_5). (from interpro) Aerial plant organs are protected by a cuticle composed of an insoluble polymeric structural compound, cutin, which is a polyester composed of hydroxy and hydroxyepoxy fatty acids. Plant pathogenic fungi produce extracellular degradative enzymes that play an important role in pathogenesis. They include cutinase, which hydrolyses cutin, facilitating fungus penetration through the cuticle. Inhibition of the enzyme can prevent fungal infection through intact cuticles. Cutin monomers released from the cuticle by small amounts of cutinase on fungal spore surfaces can greatly increase the amount of cutinase secreted by the spore, the mechanism for which process is as yet unknown. It is shown by Masaki et al. that some Cutinase-Like enzyme hydrolyzes polylactic acid and other biodegradable plastics

Database
Sequences
Interpro
|
IPR011150 (Cutinase, monofunctional Cutinase_monf), IPR000675 (Cutinase/acetylxylan esterase Cutinase/axe)
PIRSF
|
Pdoc
|
PFam
|
PF01083 (Cutinase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
15 more
    Title: Fusarium solani cutinase is a lipolytic enzyme with a catalytic serine accessible to solvent
    Martinez C, de Geus P, Lauwereys M, Matthyssens G, Cambillau C
    Ref: Nature, 356:615, 1992 : PubMed

            

    Title: Cloning and analysis of CUT1, a cutinase gene from Magnaporthe grisea
    Sweigard JA, Chumley FG, Valent B
    Ref: Molecular & General Genetics, 232:174, 1992 : PubMed

            

    Title: Structure of cutinase gene, cDNA, and the derived amino acid sequence from phytopathogenic fungi
    Ettinger WF, Thukral SK, Kolattukudy PE
    Ref: Biochemistry, 26:7883, 1987 : PubMed

            

Other Papers


Structure scheme for Cutinase

Structures in Cutinase family (65)

Genes Proteins in Cutinase family (559)

Fragments of genes in Cutinase family (16)

Substrates of some enzymes in the Cutinase family (21)

Inhibitors of some enzymes in the Cutinase family (29)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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