rhosm-cocE

Rhodococcus sp. (strain MB1 Bresler) cocaine esterase (EC 3.1.1.-)

Comment

Relationship

Family : Cocaine_esterase

Block : X

Position in NCBI Life Tree : Rhodococcus sp.

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Nocardiaceae N E > Rhodococcus N E > Rhodococcus sp. N E

Database

Sequence

Peptide

MVDGNYSVAS NVMVPMRDGV RLAVDLYRPD ADGPVPVLLV RNPYDKFDVF AWSTQSTNWL EFVRDGYAVV IQDTRGLFAS EGEFVPHVDD EADAEDTLSW ILEQAWCDGN VGMFGVSYLG VTQWQAAVSG VGGLKAIAPS MASADLYRAP WYGPGGALSV EALLGWSALI GTGLITSRSD ARPEDAADFV QLAAILNDVA GAASVTPLAE QPLLGRLIPW VIDQVVDHPD NDESWQSISL FERLGGLATP ALITAGWYDG FVGESLRTFV AVKDNADARL VVGPWSHSNL TGRNADRKFG IAATYPIQEA TTMHKAFFDR HLRGETDALA GVPKVRLFVM GIDEWRDETD WPLPDTAYTP FYLGGSGAAN TSTGGGTLST SISGTESADT YLYDPADPVP SLGGTLLFHN GDNGPADQRP IHDRDDVLCY STEVLTDPVE VTGTVSARLF VSSSAVDTDF TAKLVDVFPD GRAIALCDGI VRMRYRETLV NPTLIEAGEI YEVAIDMLAT SNVFLPGHRI MVQVSSSNFP KYDRNSNTGG VIAREQLEEM CTAVNRIHRG PEHPSHIVLP IIKR

References (9)

Title : Computational Design and Crystal Structure of a Highly Efficient Benzoylecgonine Hydrolase - Chen_2021_Angew.Chem.Int.Ed.Engl_60_21959
Author(s) : Chen X , Deng X , Zhang Y , Wu Y , Yang K , Li Q , Wang J , Yao W , Tong J , Xie T , Hou S , Yao J
Ref : Angew Chem Int Ed Engl , 60 :21959 , 2021
PubMedID: 34351032
Gene_locus related to this paper: rhosm-cocE

Title : Computational design of cephradine synthase in a new scaffold identified from structural databases - Huang_2017_Chem.Commun.(Camb)_53_7604
Author(s) : Huang X , Xue J , Zhu Y
Ref : Chem Commun (Camb) , 53 :7604 , 2017
PubMedID: 28639649
Gene_locus related to this paper: rhosm-cocE

Title : Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification - Fang_2014_ACS.Chem.Biol_9_1764
Author(s) : Fang L , Chow KM , Hou S , Xue L , Chen X , Rodgers DW , Zheng F , Zhan CG
Ref : ACS Chemical Biology , 9 :1764 , 2014
PubMedID: 24919140
Gene_locus related to this paper: rhosm-cocE

Title : Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time - Narasimhan_2011_Mol.Pharmacol_80_1056
Author(s) : Narasimhan D , Collins GT , Nance MR , Nichols J , Edwald E , Chan J , Ko MC , Woods JH , Tesmer JJ , Sunahara RK
Ref : Molecular Pharmacology , 80 :1056 , 2011
PubMedID: 21890748
Gene_locus related to this paper: rhosm-cocE

Title : Structural analysis of thermostabilizing mutations of cocaine esterase - Narasimhan_2010_Protein.Eng.Des.Sel_23_537
Author(s) : Narasimhan D , Nance MR , Gao D , Ko MC , MacDonald J , Tamburi P , Yoon D , Landry DM , Woods JH , Zhan CG , Tesmer JJ , Sunahara RK
Ref : Protein Engineering Des Sel , 23 :537 , 2010
PubMedID: 20436035
Gene_locus related to this paper: rhosm-cocE

Title : A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse - Brim_2010_Mol.Pharmacol_77_593
Author(s) : Brim RL , Nance MR , Youngstrom DW , Narasimhan D , Zhan CG , Tesmer JJ , Sunahara RK , Woods JH
Ref : Molecular Pharmacology , 77 :593 , 2010
PubMedID: 20086035
Gene_locus related to this paper: rhosm-cocE

Title : Crystal structure of a bacterial cocaine esterase -
Author(s) : Larsen NA , Turner JM , Stevens J , Rosser SJ , Basran A , Lerner RA , Bruce NC , Wilson IA
Ref : Nat Struct Biol , 9 :17 , 2002
PubMedID: 11742345
Gene_locus related to this paper: rhosm-cocE

Title : Biochemical characterization and structural analysis of a highly proficient cocaine esterase - Turner_2002_Biochemistry_41_12297
Author(s) : Turner JM , Larsen NA , Basran A , Barbas CF, 3rd , Bruce NC , Wilson IA , Lerner RA
Ref : Biochemistry , 41 :12297 , 2002
PubMedID: 12369817
Gene_locus related to this paper: rhosm-cocE

Title : Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1 - Bresler_2000_Appl.Environ.Microbiol_66_904
Author(s) : Bresler MM , Rosser SJ , Basran A , Bruce NC
Ref : Applied Environmental Microbiology , 66 :904 , 2000
PubMedID: 10698749
Gene_locus related to this paper: rhosm-cocE