1. Home
  2. Family
  3. Cocaine_esterase

Cocaine_esterase

Relationship

Family: Cocaine_esterase

Block: X

Parent Family: Peptidase_S15

Comment

Contains also alpha-amino acid ester hydrolase (Beta-Lactam Acylase), glutaryl 7-aca acylases, antibiotic hydrolase, diester hydrolase. Able to perform both hydrolysis and synthesis of a variety of -amino -lactam antibiotics including (R)-ampicillin and cephalexin. The closest relatives is the S15 X-prolyl amino peptidase of Lactobacillus

Database

Interpro : IPR005674 CocE\/NonD hydrolase

PIRSF : PIRSF031658

Pdoc : No Pdoc

Pfam : PF02129 Peptidase_S15

Prints : No Print

EC Number : 3.1.1.43

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (24)

Genes Proteins in Cocaine_esterase family (116)

Fragments of genes in Cocaine_esterase family (4)

Structures in Cocaine_esterase family (24)

Substrates in Cocaine_esterase family (7)

Inhibitors in Cocaine_esterase family (5)

References (3)

Title : Amino ester hydrolase from Xanthomonas campestris pv. campestris, ATCC 33913 for enzymatic synthesis of ampicillin - Blum_2010_J.Mol.Catal.B.Enzym_67_21
Author(s) : Blum JK , Bommarius AS
Ref : J Mol Catal B Enzym , 67 :21 , 2010
Abstract : Blum_2010_J.Mol.Catal.B.Enzym_67_21
ESTHER : Blum_2010_J.Mol.Catal.B.Enzym_67_21
PubMedSearch : Blum_2010_J.Mol.Catal.B.Enzym_67_21
PubMedID: 22087071
Gene_locus related to this paper: xanax-GAA

Title : Crystal structure of a bacterial cocaine esterase -
Author(s) : Larsen NA , Turner JM , Stevens J , Rosser SJ , Basran A , Lerner RA , Bruce NC , Wilson IA
Ref : Nat Struct Biol , 9 :17 , 2002
PubMedID: 11742345
Gene_locus related to this paper: rhosm-cocE

Title : Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1 - Bresler_2000_Appl.Environ.Microbiol_66_904
Author(s) : Bresler MM , Rosser SJ , Basran A , Bruce NC
Ref : Applied Environmental Microbiology , 66 :904 , 2000
Abstract : Bresler_2000_Appl.Environ.Microbiol_66_904
ESTHER : Bresler_2000_Appl.Environ.Microbiol_66_904
PubMedSearch : Bresler_2000_Appl.Environ.Microbiol_66_904
PubMedID: 10698749
Gene_locus related to this paper: rhosm-cocE