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Gene_locus Report for: arath-At5g14930

Arabidopsis thaliana (Mouse-ear cress) At5g14930 sag101 AtSAG101

Comment
The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-pad4 F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance.EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4) mediate TNL receptor defence signalling.


Relationship
Family|Plant_lipase_EDS1-like
Block| L
Position in NCBI Life Tree|Arabidopsis thaliana
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Viridiplantae: N E > Streptophyta: N E > Streptophytina: N E > Embryophyta: N E > Tracheophyta: N E > Euphyllophyta: N E > Spermatophyta: N E > Magnoliophyta: N E > Mesangiospermae: N E > eudicotyledons: N E > Gunneridae: N E > Pentapetalae: N E > rosids: N E > malvids: N E > Brassicales: N E > Brassicaceae: N E > Camelineae: N E > Arabidopsis: N E > Arabidopsis thaliana: N E


Molecular evidence
Database
No mutation
2 structures: 4NFU, 7XJP
No kinetic





No Substrate
No inhibitor
>3 Genbank links 1 more: AF239888, AF239887, AL391146
1 UniProt : Q4F883
2 Structure : 7XJP, 4NFU
3 UniProt : Q9LL47, Q9LL48, Q4F883
3 Interpro : Q9LL47, Q9LL48, Q4F883
3 Prodom : Q9LL47, Q9LL48, Q4F883
3 Pfam : Q9LL47, Q9LL48, Q4F883
3 PIRSF : Q9LL47, Q9LL48, Q4F883
3 SUPERFAM : Q9LL47, Q9LL48, Q4F883
1 Tair database : At5g14930
Sequence
Graphical view for this peptide sequence: arath-At5g14930
Colored MSA for Plant_lipase_EDS1-like (raw)
MIRVYKFQKKKDSGLEFQIHREEKFTLVVFSAPPICRSSSSDSTLLHVKD
KENPFPFLCSENNPSFSLHTPAFNLFTSAPTSLTYLKSELLQTLKSEKPV
IITGAALGGSVASLYTLWLLETIEPTLKRPLCITFGSPLIGDASLQQILE
NSVRNSCFLHVVSAQTRIKMDFFKPFGTFLICFDSGCVCIEDHVAVTELL
NGVHDSGLVDYSQVLNRLDQSMLSLADSRLIPEDVIKGIEKRAEMKNLRF
DMMFKKLNDMKISMAYIEWYKKKCKEVKIGYYDRFKTQLAFPSKEFDINI
KNHHKSELNRFWKSVVEEVERRPQSDASILKRRFLFSGNNYRRMIEPLDI
AEYYLEGRKEYRTMGRSHHYVMLEKWFGMESILIEKERCKKRDLSDLLTF
DSCFWAEVEDSLIVINQLNTTVGMRDDEREVLTRKLVEFEGYVWEIITKR
EVSPEIFLEESSFMKWWKEYKKIKGFNSSYLTEFMNTRKYESYGKSQ
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MIRVYKFQKKKDSGLEFQIHREEKFTLVVFSAPPICRSSSSDSTLLHVKD
KENPFPFLCSENNPSFSLHTPAFNLFTSAPTSLTYLKSELLQTLKSEKPV
IITGAALGGSVASLYTLWLLETIEPTLKRPLCITFGSPLIGDASLQQILE
NSVRNSCFLHVVSAQTRIKMDFFKPFGTFLICFDSGCVCIEDHVAVTELL
NGVHDSGLVDYSQVLNRLDQSMLSLADSRLIPEDVIKGIEKRAEMKNLRF
DMMFKKLNDMKISMAYIEWYKKKCKEVKIGYYDRFKTQLAFPSKEFDINI
KNHHKSELNRFWKSVVEEVERRPQSDASILKRRFLFSGNNYRRMIEPLDI
AEYYLEGRKEYRTMGRSHHYVMLEKWFGMESILIEKERCKKRDLSDLLTF
DSCFWAEVEDSLIVINQLNTTVGMRDDEREVLTRKLVEFEGYVWEIITKR
EVSPEIFLEESSFMKWWKEYKKIKGFNSSYLTEFMNTRKYESYGKSQ


References
5 more
    Title: Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity
    Dongus JA, Bhandari DD, Penner E, Lapin D, Stolze SC, Harzen A, Patel M, Archer L, Dijkgraaf L and Parker JE <2 more author(s)>
    Ref: Plant J, :, 2022 : PubMed

            

    Title: Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity
    Sun X, Lapin D, Feehan JM, Stolze SC, Kramer K, Dongus JA, Rzemieniewski J, Blanvillain-Baufume S, Harzen A and Parker JE <6 more author(s)>
    Ref: Nat Commun, 12:3335, 2021 : PubMed

            

    Title: A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors
    Lapin D, Kovacova V, Sun X, Dongus JA, Bhandari D, von Born P, Bautor J, Guarneri N, Rzemieniewski J and Parker JE <2 more author(s)>
    Ref: Plant Cell, 31:2430, 2019 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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