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Gene_locus Report for: canlf-e2r2h2

Canis lupus familiaris (Dog) (Canis familiaris). Arylacetamide deacetylase AADAC

Comment
other strains: Canis lupus familiaris (Dog) (Canis familiaris) Canis lupus dingo (dingo)


Relationship
Family|Arylacetamide_deacetylase
Block| H
Position in NCBI Life Tree|Canis lupus familiaris
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Carnivora: N E > Caniformia: N E > Canidae: N E > Canis: N E > Canis lupus: N E > Canis lupus familiaris: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
Sequence
Graphical view for this peptide sequence: canlf-e2r2h2
Colored MSA for Arylacetamide_deacetylase (raw)
MGRKTILLLIMGVFWAYYIYIPLPDNIEESWKLLCMTTYWKILTDLSLFA
ELLGVNHFMNIFMFFMNLQEVPPTSDENVTVMETTFNNVPVRVYVPKRKP
ERLRRGLFYIHGGGWCLGSAAFLGYDSLSRRTADRLDAVVISTNYRLAPK
YHFPNQFEDVYNALKGFMRQDVLDKYGVDPERIGISGDSAGGNLAAAVAQ
QLIDDPDVEINLKTQCLIYPALQTLDMDLPSYRENSHFPILPKSLMVRFW
SEYFTVDKSLVKAMFSNQHVPVESSHLYKFINWSSLLPEKFKKGYFYKSP
TYGSSELAKKYPGFLDVRAAPLLADDNKLRSLPLTYVITCQYDVLRDDGI
MYVTRLQNAGVQVTHNHIEDGFHGAFSFSGFKIADRLENQYMNWLSENL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MGRKTILLLIMGVFWAYYIYIPLPDNIEESWKLLCMTTYWKILTDLSLFA
ELLGVNHFMNIFMFFMNLQEVPPTSDENVTVMETTFNNVPVRVYVPKRKP
ERLRRGLFYIHGGGWCLGSAAFLGYDSLSRRTADRLDAVVISTNYRLAPK
YHFPNQFEDVYNALKGFMRQDVLDKYGVDPERIGISGDSAGGNLAAAVAQ
QLIDDPDVEINLKTQCLIYPALQTLDMDLPSYRENSHFPILPKSLMVRFW
SEYFTVDKSLVKAMFSNQHVPVESSHLYKFINWSSLLPEKFKKGYFYKSP
TYGSSELAKKYPGFLDVRAAPLLADDNKLRSLPLTYVITCQYDVLRDDGI
MYVTRLQNAGVQVTHNHIEDGFHGAFSFSGFKIADRLENQYMNWLSENL


References
    Title: Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans
    Yoshida T, Fukami T, Kurokawa T, Gotoh S, Oda A, Nakajima M
    Ref: Eur J Pharm Sci, 111:167, 2018 : PubMed

            

    Title: Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ, 3rd and Lander ES <224 more author(s)>
    Ref: Nature, 438:803, 2005 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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