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2-Oxoindolin-thiazoline-Cpd3i

AChE K (i) = 59.71 +/- 2.24 nM; BChE K (i) = 8.43 +/- 0.97 nM; AChE IC50 70.81 +/- 1.19 BChE IC50 10.87 +/- 1.17

General

Type : Sulfur Compound, Thiazole, Trifluoro, Multitarget, PPARgamma ligand, Indole, Carbothioamide

Chemical_Nomenclature : amino[(1Z)-1-benzyl-2-oxo-5-(trifluoromethyloxy)indolin-3-ylideneamino]carbothioamide

Canonical SMILES : C1(=CC=C2C(=C1)C(C(N2CC3=CC=CC=C3)=O)=NNC(N)=S)OC(F)(F)F

InChI : InChI=1S\/C17H13F3N4O2S\/c18-17(19,20)26-11-6-7-13-12(8-11)14(22-23-16(21)27)15(25)24(13)9-10-4-2-1-3-5-10\/h1-8H,9H2,(H3,21,23,27)

InChIKey : ZQLUSYIZHYQIRA-UHFFFAOYSA-N

Other name(s) : (Z)-1-Benzyl-3-thiosemicarbazidoidene-5-trifluoromethoxy-2-indolinone  ||  Compound 3i

MW : 394.370

Formula : C17H13F3N4O2S

CAS_number :

PubChem :

UniChem : ZQLUSYIZHYQIRA-UHFFFAOYSA-N

Target

Families : 2-Oxoindolin-thiazoline-Cpd3i ligand of proteins in family
ACHE BCHE

Protein :
human-ACHE human-BCHE

References (1)

Title : 2-Oxoindolin-thiazoline hybrids as scaffold-based therapeutics for T2DM-associated cognitive impairment: design, synthesis, in vitro and in silico studies - Qayed_2025_RSC.Med.Chem__
Author(s) : Qayed WS , Hassan MA , Senol H , Taslimi P , Aboul-Fadl T
Ref : RSC Med Chem , : , 2025
Abstract :
PubMedSearch : Qayed_2025_RSC.Med.Chem__
PubMedID: 41244754