Compound of the cristallization buffer (necessary). It is found in multiple place in the structure but found also in active site in a position compatible with substrate
Type : Analogue of substrate
Chemical_Nomenclature : (4S)-2-methylpentane-2,4-diol
Canonical SMILES : CC(CC(C)(C)O)O
InChI : InChI=1S\/C6H14O2\/c1-5(7)4-6(2,3)8\/h5,7-8H,4H2,1-3H3\/t5-\/m0\/s1
InChIKey : SVTBMSDMJJWYQN-YFKPBYRVSA-N
Other name(s) : MPD || (4S)-2-Methyl-2,4-pentanediol || (S)-2-Methyl-2,4-pentanediol || (4S)-2-methylpentane-2,4-diol || (S)-(+)-2-Methyl-2,4-pentandiol || (S)-(+)-2-Methyl-2,4-pentanediol || 2-methyl-2,4-pentanediol || (MPD)-O4
MW : 118.17
Formula : C6H14O2
CAS_number : 99113-75-4
PubChem : 5288834
UniChem : SVTBMSDMJJWYQN-YFKPBYRVSA-N
Families : 2-methyl-pentane-2,4-diol ligand of proteins in family
Monoglyceridelipase_lysophospholip
Hydroxynitrile_lyase
ABHD10
A85-Feruloyl-Esterase
RsbQ-like
Structure :
7XRT
6NY9
8VD1
3JW8
1EB8
Protein :
human-MGLL
manes-hnl
mouse-abhda
bactn-BT4077
orysj-q10j20
Title : Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction - Guercio_2024_J.Biol.Chem__107593 |
Author(s) : Guercio AM , Gilio AK , Pawlak J , Shabek N |
Ref : Journal of Biological Chemistry , :107593 , 2024 |
Abstract : |
PubMedSearch : Guercio_2024_J.Biol.Chem__107593 |
PubMedID: 39032651 |
Gene_locus related to this paper: arath-KAI2.D14L , orysj-q10j20 |
Title : Structural insights into the oligomeric effects on catalytic activity of a decameric feruloyl esterase and its application in ferulic acid production - Du_2023_Int.J.Biol.Macromol__126540 |
Author(s) : Du G , Wang Y , Zhang Y , Yu H , Liu S , Ma X , Cao H , Wei X , Wen B , Li Z , Fan S , Zhou H , Xin F |
Ref : Int J Biol Macromol , :126540 , 2023 |
Abstract : |
PubMedSearch : Du_2023_Int.J.Biol.Macromol__126540 |
PubMedID: 37634773 |
Gene_locus related to this paper: bactn-BT4077 |
Title : ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 - Cao_2019_Nat.Chem.Biol_15_1232 |
Author(s) : Cao Y , Qiu T , Kathayat RS , Azizi SA , Thorne AK , Ahn D , Fukata Y , Fukata M , Rice PA , Dickinson BC |
Ref : Nat Chemical Biology , 15 :1232 , 2019 |
Abstract : |
PubMedSearch : Cao_2019_Nat.Chem.Biol_15_1232 |
PubMedID: 31740833 |
Gene_locus related to this paper: human-ABHD10 , mouse-abhda |
Title : Structural basis for human monoglyceride lipase inhibition - Bertrand_2010_J.Mol.Biol_396_663 |
Author(s) : Bertrand T , Auge F , Houtmann J , Rak A , Vallee F , Mikol V , Berne PF , Michot N , Cheuret D , Hoornaert C , Mathieu M |
Ref : Journal of Molecular Biology , 396 :663 , 2010 |
Abstract : |
PubMedSearch : Bertrand_2010_J.Mol.Biol_396_663 |
PubMedID: 19962385 |
Gene_locus related to this paper: human-MGLL |
Title : Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta - Lauble_2002_Protein.Sci_11_65 |
Author(s) : Lauble H , Miehlich B , Forster S , Kobler C , Wajant H , Effenberger F |
Ref : Protein Science , 11 :65 , 2002 |
Abstract : |
PubMedSearch : Lauble_2002_Protein.Sci_11_65 |
PubMedID: 11742123 |
Gene_locus related to this paper: manes-hnl |