3-amino-4-phenyl-pyrrolidine-15B
General
Type : Trifluoro, Pyrrolidine, Pyridine, Pyrimidine
Chemical_Nomenclature : (3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Canonical SMILES : COC1=NC=C(C=C1)C2=CC(=NC=N2)N3CC(C(C3)N)C4=CC(=C(C=C4F)F)F
InChI : InChI=1S\/C20H18F3N5O\/c1-29-20-3-2-11(7-25-20)18-6-19(27-10-26-18)28-8-13(17(24)9-28)12-4-15(22)16(23)5-14(12)21\/h2-7,10,13,17H,8-9,24H2,1H3\/t13-,17+\/m1\/s1
InChIKey : IFKWHPAWYJARQJ-DYVFJYSZSA-N
Other name(s) : PZF || CHEMBL237786 || (3R,4S)-1-(6-(6-methoxypyridin-3-yl)pyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine || BDBM50221073 || DB08445
MW : 401.39
Formula : C20H18F3N5O
CAS_number :
PubChem : 24180585
UniChem : IFKWHPAWYJARQJ-DYVFJYSZSA-N
Target
Families : 3-amino-4-phenyl-pyrrolidine-15B ligand of proteins in family
DPP4N_Peptidase_S9
Structure :
2QJR
Protein :
human-DPP4
References (1)
| Title : (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization - Wright_2007_Bioorg.Med.Chem.Lett_17_5638 |
| Author(s) : Wright SW , Ammirati MJ , Andrews KM , Brodeur AM , Danley DE , Doran SD , Lillquist JS , Liu S , McClure LD , McPherson RK , Olson TV , Orena SJ , Parker JC , Rocke BN , Soeller WC , Soglia CB , Treadway JL , VanVolkenburg MA , Zhao Z , Cox ED |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5638 , 2007 |
| Abstract : |
| PubMedSearch : Wright_2007_Bioorg.Med.Chem.Lett_17_5638 |
| PubMedID: 17822893 |
| Gene_locus related to this paper: human-DPP4 |