Benzyl-piperidyl-ethyl-dimethoxy-indole-carboxamide-Cpd12
IC50 AChE 0.32 microM; BACE-1 0.39 microM. Kumar et al is not the primary publication very similar to Indole-piperidine-amide-cpd23a. In fact probably a mistake
General
Type : Derivative of Donepezil, Piperidine, Indole, Carboxamide, Multitarget, BACE1-inhibitor, Benzylpiperidine
Chemical_Nomenclature : N-[2-(1-benzylpiperidin-4-yl)ethyl]-5,6-dimethoxy-1H-indole-3-carboxamide
Canonical SMILES : C1CN(CCC1CCNC(=O)C2=C[N]C3=CC(=C(C=C23)OC)OC)CC4=CC=CC=C4
InChI : InChI=1S\/C25H31N3O3\/c1-30-23-14-20-21(16-27-22(20)15-24(23)31-2)25(29)26-11-8-18-9-12-28(13-10-18)17-19-6-4-3-5-7-19\/h3-7,14-16,18,27H,8-13,17H2,1-2H3,(H,26,29)
InChIKey : DFBRESHZOVHRPQ-UHFFFAOYSA-N
Other name(s) : N-[2-(1-Benzyl-4-piperidyl)ethyl]-5,6-dimethoxy-3-indolecarboxamide || Compound 12
Target
Families : Benzyl-piperidyl-ethyl-dimethoxy-indole-carboxamide-Cpd12 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Recent developments in donepezil-based hybrid molecules as multi-target therapeutics for Alzheimer's disease: A paradigm shift beyond symptomatic treatment - Kumar_2026_Bioorg.Chem_181_110361 |
| Author(s) : Kumar N , Khan I , Singh J , Kumar K , Kushwaha VK , Ojha S , Raman SK , Shankar G |
| Ref : Bioorg Chem , 181 :110361 , 2026 |
| Abstract : |
| PubMedSearch : Kumar_2026_Bioorg.Chem_181_110361 |
| PubMedID: 42600466 |