Benzylpiperazinephenyl-phenyl-pyrazol-cpd48
AChE IC50 = 2.89 +/- 0.706 microM; BuChE IC50 = 0.151 +/- 0.089 microM), BACE-1 percent inhibition = 36.64 +/- 1.343 %) and amyloid-beta aggregation inhibition
General
Type : Multitarget, BACE1-inhibitor, anti-Abeta-aggregation, Piperazine, Pyrazole
Chemical_Nomenclature : 1-(5-(4-(4-Benzylpiperazin-1-yl)phenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one
Canonical SMILES : C1=CC=CC(=C1)C2=NN(C(C2)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5)C(C)=O
InChI : InChI=1S\/C28H30N4O\/c1-22(33)32-28(20-27(29-32)24-10-6-3-7-11-24)25-12-14-26(15-13-25)31-18-16-30(17-19-31)21-23-8-4-2-5-9-23\/h2-15,28H,16-21H2,1H3
InChIKey : FIBWFGCIYYNXLY-UHFFFAOYSA-N
Other name(s) : Compound 48
Target
Families : Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of pyrazoline analogs as multi-targeting cholinesterase, beta-secretase and Abeta aggregation inhibitors through lead optimization strategy - Bajad_2025_Int.J.Biol.Macromol_301_140436 |
| Author(s) : Bajad NG , Jangra J , T AG , Kumar A , Krishnamurthy S , Singh SK |
| Ref : Int J Biol Macromol , 301 :140436 , 2025 |
| Abstract : |
| PubMedSearch : Bajad_2025_Int.J.Biol.Macromol_301_140436 |
| PubMedID: 39884636 |