Bipiperidyl-oxoethyl-phenyl-tetraaza-dihydro-indenone-Cpd9a
Compound 9a IC50 AChE 0.168 microM 9a; Abeta inhibitory activit IC50 = 1.060 microM
General
Type : Derivative of Donepezil, Multitarget, Piperidine, Inden, anti-tau-aggregation, Indole, Pyrazole, Pyrimidine
Chemical_Nomenclature : 5-[2-([1,4'-bipiperidin]-1'-yl)-2-oxoethyl]-1-phenyl-1,2,5,7-tetraaza-1,5-dihydro-4H-inden-4-one
Canonical SMILES : C14=C(N=CN(C1=O)CC(N2CCC(CC2)N3CCCCC3)=O)[N](N=C4)C5=CC=CC=C5
InChI : InChI=1S\/C23H28N6O2\/c30-21(27-13-9-18(10-14-27)26-11-5-2-6-12-26)16-28-17-24-22-20(23(28)31)15-25-29(22)19-7-3-1-4-8-19\/h1,3-4,7-8,15,17-18H,2,5-6,9-14,16H2
InChIKey : KQYCVAZFSIWEDF-UHFFFAOYSA-N
Other name(s) : Compound 9a || 5-[2-(1,4'-Bipiperidyl-1'-yl)-2-oxoethyl]-1-phenyl-1,2,5,7-tetraaza-1,5-dihydro-4H-inden-4-one
Target
Families : Bipiperidyl-oxoethyl-phenyl-tetraaza-dihydro-indenone-Cpd9a ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, Synthesis, In Vitro and In Vivo Biological Evaluation of Novel Pyrazolo[3,4-d]Pyrimidine-Based Derivatives as Promising Multitarget Candidates for Alzheimer's Disease - Nemr_2026_Drug.Dev.Res_87_e70259 |
| Author(s) : Nemr MTM , Mohamed LW , Sayed HS , Mikhail DS |
| Ref : Drug Dev Res , 87 :e70259 , 2026 |
| Abstract : |
| PubMedSearch : Nemr_2026_Drug.Dev.Res_87_e70259 |
| PubMedID: 41773918 |