BuChE-IN-TM-10
IC50 6.3 microM and 8.6 microMM against MAO-A and MAO-B. AChE IC50 12.1 microM, BuChE IC50 8.9 nM. Selective for BuChE over AChE
General
Type : Feruloyl, Hydroxycinnamic-ester, Multitarget, Isoquinoline, Monoamine-oxidase-inhibitor
Chemical_Nomenclature : (E)-3-[4-[4-[benzyl(ethyl)amino]butoxy]-3-methoxyphenyl]-1-(3,4-dihydro-1H-isoquinolin-2-yl)prop-2-en-1-one
Canonical SMILES : CCN(CCCCOC1=C(C=C(C=C1)C=CC(=O)N2CCC3=CC=CC=C3C2)OC)CC4=CC=CC=C4
InChI : InChI=1S\/C32H38N2O3\/c1-3-33(24-27-11-5-4-6-12-27)20-9-10-22-37-30-17-15-26(23-31(30)36-2)16-18-32(35)34-21-19-28-13-7-8-14-29(28)25-34\/h4-8,11-18,23H,3,9-10,19-22,24-25H2,1-2H3\/b18-16+
InChIKey : CGZGXSZYVAXOGJ-FBMGVBCBSA-N
Other name(s) : CHEMBL5170410 || EX-A8339 || BDBM50590392
MW : 498.7
Formula : C32H38N2O3
CAS_number : 2313524-95-5
PubChem : 138454766
UniChem : CGZGXSZYVAXOGJ-FBMGVBCBSA-N
Target
References (1)
| Title : Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease - Sang_2019_ACS.Chem.Neurosci_10_1008 |
| Author(s) : Sang Z , Wang K , Han X , Cao M , Tan Z , Liu W |
| Ref : ACS Chem Neurosci , 10 :1008 , 2019 |
| Abstract : |
| PubMedSearch : Sang_2019_ACS.Chem.Neurosci_10_1008 |
| PubMedID: 30537804 |