CHEMBL4559005
specific for MGLL over FAAH IC50 MGLL 8nM
General
Type : Naphthalen, Piperazine, Pyrazole, Cyanide
Chemical_Nomenclature : 1-[4-(dinaphthalen-2-ylmethyl)piperazine-1-carbonyl]pyrazole-4-carbonitrile
Canonical SMILES : C1CN(CCN1C(C2=CC3=CC=CC=C3C=C2)C4=CC5=CC=CC=C5C=C4)C(=O)N6C=C(C=N6)C#N
InChI : InChI=1S\/C30H25N5O\/c31-19-22-20-32-35(21-22)30(36)34-15-13-33(14-16-34)29(27-11-9-23-5-1-3-7-25(23)17-27)28-12-10-24-6-2-4-8-26(24)18-28\/h1-12,17-18,20-21,29H,13-16H2
InChIKey : UJIAUZYNODIQTQ-UHFFFAOYSA-N
Other name(s) : BDBM50505181 || Compound 45c
MW : 471.6
Formula : C30H25N5O
CAS_number :
PubChem : 155557420
UniChem : UJIAUZYNODIQTQ-UHFFFAOYSA-N
Target
Families : CHEMBL4559005 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases - Otrubova_2019_Bioorg.Med.Chem_27_1693 |
| Author(s) : Otrubova K , Chatterjee S , Ghimire S , Cravatt BF , Boger DL |
| Ref : Bioorganic & Medicinal Chemistry , 27 :1693 , 2019 |
| Abstract : |
| PubMedSearch : Otrubova_2019_Bioorg.Med.Chem_27_1693 |
| PubMedID: 30879861 |