Carltonine-B
Amaryllidaceae alkaloid carltonine: hBChE IC50 = 0.031 +/- 0.001 microM hAChE IC50 >100 microM || hBChE IC50 = 0.031 +/- 0.001 microM; hAChE IC50 >100 microM. Competitive inhibition with Ki value of 0.055 microM
General
Chemical_Nomenclature :
Canonical SMILES : C12=CC(=C(C=C1OCO2)CN(CCC3=CC=C(C=C3)O)C)C4=CC=CC5=C4N(CC5)C
InChI : InChI=1S\/C26H28N2O3\/c1-27(12-10-18-6-8-21(29)9-7-18)16-20-14-24-25(31-17-30-24)15-23(20)22-5-3-4-19-11-13-28(2)26(19)22\/h3-9,14-15,29H,10-13,16-17H2,1-2H3
InChIKey : LHQRGHUIBBGUCH-UHFFFAOYSA-N
Other name(s) : Carltonine B || CHEMBL5426641 || BDBM50626796
MW : 416.51
Formula : C26H28N2O3
CAS_number :
PubChem : 172467146
UniChem : LHQRGHUIBBGUCH-UHFFFAOYSA-N
Target
Families : Carltonine-B ligand of proteins in family
BCHE
Protein :
human-BCHE
References (6)
| Title : Carltonine B derivatives: Synthesis and structure-activity relationship insights for selective butyrylcholinesterase inhibition - Al Mamun_2026_Bioorg.Chem_177_109894 |
| Author(s) : Al Mamun A , Konecny J , Hrabinova M , Sorf A , Muckova L , Fibigar J , Kucera T , Pulkrabkova L , Jun D , Prchal L , Panek D , Finger V , Soukup O , Cailly T , Collot V , Novakova L , Cahlikova L , Korabecny J |
| Ref : Bioorg Chem , 177 :109894 , 2026 |
| Abstract : |
| PubMedSearch : Al Mamun_2026_Bioorg.Chem_177_109894 |
| PubMedID: 42060983 |
| Title : Total Syntheses of the Amaryllidaceae Alkaloids Carltonines A-C and the Neuroprotective and Immunomodulatory Evaluation of Carltonine B - Reichau_2025_J.Nat.Prod__ |
| Author(s) : Reichau K , Scheiner M , Poeta E , Bringmann G , Monti B , Decker M |
| Ref : Journal of Natural Products , : , 2025 |
| Abstract : |
| PubMedSearch : Reichau_2025_J.Nat.Prod__ |
| PubMedID: 41066687 |
| Title : Carltonine-Derived Compounds for Targeted Butyrylcholinesterase Inhibition - Pidany_2024_RSC.Med.Chem_15_1601 |
| Author(s) : Pidany F , Kroustkova J , Jenco J , Breiterova K , Muckovab L , Novakova L , Kunes J , Fibigar J , Kucera T , Novak M , Sorf A , Hrabinova M , Pulkrabkova L , Janousek J , Soukup O , Jun D , Korabecny J , Cahlikova L |
| Ref : RSC Med Chem , 15 :1601 , 2024 |
| Abstract : |
| PubMedSearch : Pidany_2024_RSC.Med.Chem_15_1601 |
| PubMedID: 38784455 |
| Gene_locus related to this paper: human-BCHE |
| Title : Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation - Pidany_2023_Eur.J.Med.Chem_252_115301 |
| Author(s) : Pidany F , Kroustkova J , Al Mamun A , Suchankova D , Brazzolotto X , Nachon F , Chantegreil F , Dolezal R , Pulkrabkova L , Muckova L , Hrabinova M , Finger V , Kufa M , Soukup O , Jun D , Jenco J , Kunes J , Novakova L , Korabecny J , Cahlikova L |
| Ref : Eur Journal of Medicinal Chemistry , 252 :115301 , 2023 |
| Abstract : |
| PubMedSearch : Pidany_2023_Eur.J.Med.Chem_252_115301 |
| PubMedID: 36996715 |
| Gene_locus related to this paper: human-BCHE |
| Title : Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies - Al Mamun_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Al Mamun A , Pidany F , Hulcova D , Marikova J , Kucera T , Schmidt M , Catapano MC , Hrabinova M , Jun D , Muckova L , Kunes J , Janousek J , Andrys R , Novakova L , Perinova R , Maafi N , Soukup O , Korabecny J , Cahlikova L |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : |
| PubMedSearch : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 34361074 |
| Title : Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity - Kohelova_2020_Bioorg.Chem_107_104567 |
| Author(s) : Kohelova E , Marikova J , Korabecny J , Hulcova D , Kucera T , Jun D , Chlebek J , Jenco J , Safratova M , Hrabinova M , Ritomska A , Malanik M , Perinova R , Breiterova K , Kunes J , Novakova L , Opletal L , Cahlikova L |
| Ref : Bioorg Chem , 107 :104567 , 2020 |
| Abstract : |
| PubMedSearch : Kohelova_2020_Bioorg.Chem_107_104567 |
| PubMedID: 33387730 |