Chloro-trifluoromethoxy-phenyl-ureido-piperidine-carboxamido-methyl-benzoate
20k; HsEH IC50 = 0.8 nM, MsEH IC50 = 0.7 nM
General
Type : Carboxamide, Trifluoro, Piperidine, Benzoate, Urea derivative
Chemical_Nomenclature : 4-((4-(3-(3-Chloro-4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxamido) methyl)benzoic acid
Canonical SMILES : C1=C(C=CC(=C1)CNC(N2CCC(CC2)NC(NC3=CC=C(C(=C3)Cl)OC(F)(F)F)=O)=O)C(=O)O
InChI : InChI=1S\/C22H22ClF3N4O5\/c23-17-11-16(5-6-18(17)35-22(24,25)26)29-20(33)28-15-7-9-30(10-8-15)21(34)27-12-13-1-3-14(4-2-13)19(31)32\/h1-6,11,15H,7-10,12H2,(H,27,34)(H,31,32)(H2,28,29,33)
InChIKey : XSAGEGQEXXLRIR-UHFFFAOYSA-N
Other name(s) : Compound 20k
Target
Families : Chloro-trifluoromethoxy-phenyl-ureido-piperidine-carboxamido-methyl-benzoate ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (3)
| Title : Design and synthesis of novel sEH inhibitors for the treatment of acute lung injury - Xu_2026_Eur.J.Med.Chem_309_118773 |
| Author(s) : Xu H , Ma R , Morisseau C , Dong X , Zhuang J , Wang Z , Liu F , Xu D , Chen L , Zhang M , Zhu Z , Liu X , Jiang H , Liu Z , Hammock BD , Cao R , Chen G |
| Ref : Eur Journal of Medicinal Chemistry , 309 :118773 , 2026 |
| Abstract : |
| PubMedSearch : Xu_2026_Eur.J.Med.Chem_309_118773 |
| PubMedID: 41844112 |
| Title : Design and synthesis of novel sEH inhibitors for the treatment of acute lung injury - Xu_2026_Eur.J.Med.Chem_309_118773 |
| Author(s) : Xu H , Ma R , Morisseau C , Dong X , Zhuang J , Wang Z , Liu F , Xu D , Chen L , Zhang M , Zhu Z , Liu X , Jiang H , Liu Z , Hammock BD , Cao R , Chen G |
| Ref : Eur Journal of Medicinal Chemistry , 309 :118773 , 2026 |
| Abstract : |
| PubMedSearch : Xu_2026_Eur.J.Med.Chem_309_118773 |
| PubMedID: 41844112 |
| Title : Design and synthesis of novel sEH inhibitors for the treatment of acute lung injury - Xu_2026_Eur.J.Med.Chem_309_118773 |
| Author(s) : Xu H , Ma R , Morisseau C , Dong X , Zhuang J , Wang Z , Liu F , Xu D , Chen L , Zhang M , Zhu Z , Liu X , Jiang H , Liu Z , Hammock BD , Cao R , Chen G |
| Ref : Eur Journal of Medicinal Chemistry , 309 :118773 , 2026 |
| Abstract : |
| PubMedSearch : Xu_2026_Eur.J.Med.Chem_309_118773 |
| PubMedID: 41844112 |