Choline

"Product of hydrolysis of acetylcholine by cholinesterases.A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism."

General

Type : Natural,Trimethylammonium

Chemical_Nomenclature : [2-hydroxyethyl]trimethylammonium

Canonical SMILES : C[N+](C)(C)CCO

InChI : InChI=1S\/C5H14NO\/c1-6(2,3)4-5-7\/h7H,4-5H2,1-3H3\/q+1

InChIKey : OEYIOHPDSNJKLS-UHFFFAOYSA-N

Other name(s) : Bilineurine,Hepacholine,Hormocline,Biocolina,Biocoline,Cholinum,Lipotril,Neocolina,Paresan,CHT,CHEBI:15354,CHEMBL920,SCHEMBL3142,ZINC3079337,DB00122


MW : 104.2

Formula : C5H14NO

CAS_number : 62-49-7

PubChem : 305

UniChem : OEYIOHPDSNJKLS-UHFFFAOYSA-N

IUPHAR :

Wikipedia : Choline

Target

Families : Choline ligand of proteins in family: ACHE || BCHE

Stucture :

Protein : mouse-ACHE || human-BCHE

References (6)

Title : Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products - Nicolet_2003_J.Biol.Chem_278_41141
Author(s) : Nicolet Y , Lockridge O , Masson P , Fontecilla-Camps JC , Nachon F
Ref : Journal of Biological Chemistry , 278 :41141 , 2003
Abstract : Nicolet_2003_J.Biol.Chem_278_41141
ESTHER : Nicolet_2003_J.Biol.Chem_278_41141
PubMedSearch : Nicolet_2003_J.Biol.Chem_278_41141
PubMedID: 12869558
Gene_locus related to this paper: human-BCHE

Title : Effect of tetramethylammonium, choline and edrophonium on insect acetylcholinesterase: test of a kinetic model - Stojan_1999_Chem.Biol.Interact_119-120_137
Author(s) : Stojan J , Marcel V , Fournier D
Ref : Chemico-Biological Interactions , 119-120 :137 , 1999
Abstract : Stojan_1999_Chem.Biol.Interact_119-120_137
ESTHER : Stojan_1999_Chem.Biol.Interact_119-120_137
PubMedSearch : Stojan_1999_Chem.Biol.Interact_119-120_137
PubMedID: 10421447

Title : Inhibition of acetylcholinesterase by hemicholiniums, conformationally constrained choline analogues. Evaluation of aryl and alkyl substituents. Comparisons with choline and (3- hydroxyphenyl)trimethylammonium - Lee_1992_Chem.Res.Toxicol_5_411
Author(s) : Lee BH , Stelly TC , Colucci WJ , Garcia JG , Gandour RD , Quinn DM
Ref : Chemical Research in Toxicology , 5 :411 , 1992
Abstract : Lee_1992_Chem.Res.Toxicol_5_411
ESTHER : Lee_1992_Chem.Res.Toxicol_5_411
PubMedSearch : Lee_1992_Chem.Res.Toxicol_5_411
PubMedID: 1504265

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
Abstract : Lockridge_1990_Pharmacol.Ther_47_35
ESTHER : Lockridge_1990_Pharmacol.Ther_47_35
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE

Title : Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide - Whittaker_1981_Hum.Hered_31_242
Author(s) : Whittaker M , Britten JJ
Ref : Hum Hered , 31 :242 , 1981
Abstract : Whittaker_1981_Hum.Hered_31_242
ESTHER : Whittaker_1981_Hum.Hered_31_242
PubMedSearch : Whittaker_1981_Hum.Hered_31_242
PubMedID: 7287015

Title : The activity of various esterase inhibitors towards atypical human serum cholinesterase -
Author(s) : Kalow W , Davies R0
Ref : Biochemical Pharmacology , 1 :183 , 1958
PubMedID: