Chromen-oxybutanoyloxyethyl-triazol-ethyl-tacrine-Cpd17d
17d IC50 = 0.080 +/- 0.007 microM AChE; IC50 = 0.044 +/- 0.004 microM for BuChE; self-induced Abeta aggregation 58.4% +/- 2.1% at 20 microM; MAO-B IC50 = 0.18 +/- 0.01 microM
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Chromen, anti-Abeta-aggregation, Derivative of Tacrine, Acridine, Coumarin, Triazol
Chemical_Nomenclature : N-(2-(4-(2-((4-((2-oxo-2H-chromen-7-yl)oxy)butanoyl)oxy)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)-1,2,3,4-tetrahydroacridin-9-aminium chloride
Canonical SMILES : C1(=C[N](N=N1)CC[N+]C2=C4C(=NC3=C2C=CC=C3)CCCC4)CCOC(CCCOC5=CC=C6C(=C5)OC(C=C6)=O)=O.[Cl-]
InChI : InChI=1S\/C32H33N5O5.ClH\/c38-30(10-5-18-40-24-13-11-22-12-14-31(39)42-29(22)20-24)41-19-15-23-21-37(36-35-23)17-16-33-32-25-6-1-3-8-27(25)34-28-9-4-2-7-26(28)32\;\/h1,3,6,8,11-14,20-21H,2,4-5,7,9-10,15-19H2,(H,33,34)\;1H
InChIKey : QSCNURIOTPOQDD-UHFFFAOYSA-N
Other name(s) : Compound 17d
Target
Families : Chromen-oxybutanoyloxyethyl-triazol-ethyl-tacrine-Cpd17d ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Design and Synthesis of Tacrine-Coumarin Hybrids via Click Chemistry as Multifunctional Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease - Wang_2026_Molecules_31_595 |
| Author(s) : Wang X , Lu X , Jin W , Tan X , Wang G |
| Ref : Molecules , 31 :595 , 2026 |
| Abstract : |
| PubMedSearch : Wang_2026_Molecules_31_595 |
| PubMedID: 41752374 |