Cisatracurium
Neuromuscular Nondepolarizing Agent, Nicotinic Antagonist, Neuromuscular blocking agent, (close to doxacurium) Cisatracurium is the 1R-cis 1'R-cis isomer of atracurium. Atracurium and Cisatracurium undergo spontaneous non-organ-dependent Hofmann degradation at physiological pH and temperature
General
Type : Propionate, Dimethoxyphenyl, Isoquinoline, Neuromuscular Nondepolarizing Agents, Nicotinic antagonist, Bisquaternary, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : 5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl
Canonical SMILES : C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C
InChI : InChI=1S\/C53H72N2O12\/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6\/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3\/q+2\/t42-,43-,54-,55-\/m1\/s1
InChIKey : YXSLJKQTIDHPOT-LJCJQEJUSA-N
Other name(s) : cisatracurium besylate || 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
MW : 929.14
Formula : C53H72N2O12
CAS_number : 96946-42-8
PubChem : 62887
UniChem : YXSLJKQTIDHPOT-LJCJQEJUSA-N
Wikipedia : Cisatracurium_besilate
Target
Families : Cisatracurium ligand of proteins in family
BCHE
References (11)
| Title : Neuromuscular Blocking Agents in Anesthesia: A Narrative Review of Contemporary Challenges and Reversal Approaches - Radkowski_2026_J.Clin.Med_15_ |
| Author(s) : Radkowski P , Jutrzenka M , Szewczyk M , Witkowska A , Muza M , Onichimowski D , Grabarczyk L |
| Ref : J Clin Med , 15 : , 2026 |
| Abstract : |
| PubMedSearch : Radkowski_2026_J.Clin.Med_15_ |
| PubMedID: 42123245 |
| Title : Perioperative anaphylaxis in children and first successful cisatracurium desensitization - Lai_2025_Pediatr.Allergy.Immunol_36_e70066 |
| Author(s) : Lai SHY , Lee RSM , Lam CK , Yik AKH , Lim QY , Choi F , Lynch DM , Marquis KA , Zhang K , Cheong KN , Leung KKY , Lau YL , Yuen VMY , Au EYL , Castells MC , Rosa Duque JS |
| Ref : Pediatr Allergy Immunol , 36 :e70066 , 2025 |
| Abstract : |
| PubMedSearch : Lai_2025_Pediatr.Allergy.Immunol_36_e70066 |
| PubMedID: 40116290 |
| Title : Optimal dose of neostigmine antagonizing cisatracurium-induced shallow neuromuscular block in elderly patients: a randomized control study - Cao_2023_BMC.Anesthesiol_23_269 |
| Author(s) : Cao M , Huang H , Tong J , Ou Y , Liao Y |
| Ref : BMC Anesthesiol , 23 :269 , 2023 |
| Abstract : |
| PubMedSearch : Cao_2023_BMC.Anesthesiol_23_269 |
| PubMedID: 37563623 |
| Title : Neuromuscular blocking effects of cisatracurium and its antagonism with neostigmine in a canine model of autosomal-recessive centronuclear myopathy - Martin-Flores_2015_Br.J.Anaesth_115_927 |
| Author(s) : Martin-Flores M , Pare MD , Campoy L , Gleed RD |
| Ref : British Journal of Anaesthesia , 115 :927 , 2015 |
| Abstract : |
| PubMedSearch : Martin-Flores_2015_Br.J.Anaesth_115_927 |
| PubMedID: 26582854 |
| Title : Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium - Bornia_2009_J.Anesth_23_513 |
| Author(s) : Bornia EC , Bando E , Machinski M, Jr. , Pereira MW , Alves-do-Prado W |
| Ref : J Anesth , 23 :513 , 2009 |
| Abstract : |
| PubMedSearch : Bornia_2009_J.Anesth_23_513 |
| PubMedID: 19921360 |
| Title : Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia? - Baraka_2005_Middle.East.J.Anaesthesiol_18_477 |
| Author(s) : Baraka AS , Haroun-Bizri ST , Nawfal MF , Gerges FJ , Nasr VG |
| Ref : Middle East J Anaesthesiol , 18 :477 , 2005 |
| Abstract : |
| PubMedSearch : Baraka_2005_Middle.East.J.Anaesthesiol_18_477 |
| PubMedID: 16381256 |
| Title : Clinical pharmacokinetics of the newer neuromuscular blocking drugs - Atherton_1999_Clin.Pharmacokinet_36_169 |
| Author(s) : Atherton DP , Hunter JM |
| Ref : Clinical Pharmacokinetics , 36 :169 , 1999 |
| Abstract : |
| PubMedSearch : Atherton_1999_Clin.Pharmacokinet_36_169 |
| PubMedID: 10223167 |
| Title : [Esters and stereoisomers] - Nigrovic_1997_Anaesthesist_46_282 |
| Author(s) : Nigrovic V , Diefenbach C , Mellinghoff H |
| Ref : Anaesthesist , 46 :282 , 1997 |
| Abstract : |
| PubMedSearch : Nigrovic_1997_Anaesthesist_46_282 |
| PubMedID: 9229981 |
| Title : The clinical neuromuscular pharmacology of cisatracurium versus vecuronium during outpatient anesthesia - Stevens_1997_Anesth.Analg_85_1278 |
| Author(s) : Stevens JB , Walker SC , Fontenot JP |
| Ref : Anesthesia & Analgesia , 85 :1278 , 1997 |
| Abstract : |
| PubMedSearch : Stevens_1997_Anesth.Analg_85_1278 |
| PubMedID: 9390594 |
| Title : [The clinical pharmacology of mivacurium] - Diefenbach_1997_Anaesthesist_46_385 |
| Author(s) : Diefenbach C , Mellinghoff H |
| Ref : Anaesthesist , 46 :385 , 1997 |
| Abstract : |
| PubMedSearch : Diefenbach_1997_Anaesthesist_46_385 |
| PubMedID: 9245207 |
| Title : The in vitro degradation of cisatracurium, the R, cis-R'-isomer of atracurium, in human and rat plasma - Welch_1995_Clin.Pharmacol.Ther_58_132 |
| Author(s) : Welch RM , Brown A , Ravitch J , Dahl R |
| Ref : Clinical Pharmacology & Therapeutics , 58 :132 , 1995 |
| Abstract : |
| PubMedSearch : Welch_1995_Clin.Pharmacol.Ther_58_132 |
| PubMedID: 7648763 |