DPP4-PROTAC-P4-3
Alogliptin, linker, E3 ligase ligand Lenalidomide
General
Type : PROTAC, Pyridine, Piperidine, Indole, Isoindole, Cyanide, Gliptin
Chemical_Nomenclature : N-(1-{3-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyridin-4-yl}piperidin-3-yl)-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl]-hexanediamide
Canonical SMILES : C1CC(C(NC1=O)=O)N3C(C2=CC=CC(=C2C3)NC(CCCCC(NC4CN(CCC4)C5=CC(N(C(C5CC6=C(C=CC=C6)C#N)=O)C)=O)=O)=O)=O
InChI : InChI=1S\/C38H41N7O7\/c1-43-35(49)19-31(27(37(43)51)18-23-8-2-3-9-24(23)20-39)44-17-7-10-25(21-44)40-32(46)13-4-5-14-33(47)41-29-12-6-11-26-28(29)22-45(38(26)52)30-15-16-34(48)42-36(30)50\/h2-3,6,8-9,11-12,19,25,27,30H,4-5,7,10,13-18,21-22H2,1H3,(H,40,46)(H,41,47)(H,42,48,50)
InChIKey : XTVJWQBGNFNZET-UHFFFAOYSA-N
Other name(s) : N-(1-{3-[(o-Cyanophenyl)methyl]-1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-4-pyridyl}-3-piperidyl)-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]adipamide
Target
Families : DPP4-PROTAC-P4-3 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP4
References (1)
| Title : PROTAC-mediated structure-function disruption of CD26: a therapeutic strategy for driver-negative non-small cell lung cancer - Zhang_2025_EBioMedicine_122_106026 |
| Author(s) : Zhang G , Liu B , Qiao D , Gao S , Zhu X , Huang J , He W , Gao R , Zhang L , Wang J , Huang Y , Gong Q |
| Ref : EBioMedicine , 122 :106026 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_EBioMedicine_122_106026 |
| PubMedID: 41237665 |