Deriv-CHEMBL4085222-Cpd8e
Derivative of EC-7f CHEMBL4085222 published by Sang_2017_Eur.J.Med.Chem_130_379; IC50 HuBChE O.O49 microM
General
Type : Feruloyl, Derivative of Donepezil, Piperidine, Benzylpiperidine, Quinoline
Chemical_Nomenclature : (4-(4-(Benzyl(ethyl)amino)butoxy)-3-methoxyphenyl)-1-(4-benzylpiperidin-1-yl)propan-1-one
Canonical SMILES : C1=CC=CC(=C1)CN(CCCCOC2=C(C=C(C=C2)CCC(N3CCC(CC3)CC4=CC=CC=C4)=O)OC)CC
InChI : InChI=1S\/C35H46N2O3\/c1-3-36(28-32-14-8-5-9-15-32)22-10-11-25-40-33-18-16-30(27-34(33)39-2)17-19-35(38)37-23-20-31(21-24-37)26-29-12-6-4-7-13-29\/h4-9,12-16,18,27,31H,3,10-11,17,19-26,28H2,1-2H3
InChIKey : NQFFUYDVSWEXIP-UHFFFAOYSA-N
Other name(s) : Compound 8e
Target
Families : Deriv-CHEMBL4085222-Cpd8e ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease - Sang_2025_Acta.Pharm.Sin.B_15_2134 |
| Author(s) : Sang Z , Huang S , Tan W , Ban Y , Wang K , Fan Y , Chen H , Zhang Q , Liang C , Mi J , Gao Y , Zhang Y , Liu W , Wang J , Dong W , Tan Z , Tang L , Luo H |
| Ref : Acta Pharm Sin B , 15 :2134 , 2025 |
| Abstract : |
| PubMedSearch : Sang_2025_Acta.Pharm.Sin.B_15_2134 |
| PubMedID: 40486835 |