Dichlorophenyl-sulfonyl-indol-methylene-hydrazine-carbothioamide-Cpd5n
IC50 104.28 nM (AChE), 23.04 nM (BChE), and 215.50 nM (MAO-A): Ki values of 92.42 nM (AChE) and 25.35 nM (BChE) Cytotoxicity assays against SH-SY5Y neuroblastoma cells
General
Type : Hydrazide, Sulfur Compound, Indole, Sulfonamide, Urea derivative, Monoamine-oxidase-inhibitor, Multitarget, Carbothioamide
Chemical_Nomenclature : (E)-2-((1-((3,5-Dichlorophenyl)sulfonyl)-1H-indol-3-yl)methylene)-N-(2,3-dichlorophenyl)hydrazine-1-carbothioamide
Canonical SMILES : C1=CC(=C(C(=C1)NC(NN=CC2=C[N](C3=CC=CC=C23)[S](C4=CC(=CC(=C4)Cl)Cl)(=O)=O)=S)Cl)Cl
InChI : InChI=1S\/C22H14Cl4N4O2S2\/c23-14-8-15(24)10-16(9-14)34(31,32)30-12-13(17-4-1-2-7-20(17)30)11-27-29-22(33)28-19-6-3-5-18(25)21(19)26\/h1-12H,(H2,28,29,33)
InChIKey : KJASFISWDNGQNW-UHFFFAOYSA-N
Other name(s) : Compound 5n
Target
Families : Dichlorophenyl-sulfonyl-indol-methylene-hydrazine-carbothioamide-Cpd5n ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Design, synthesis, and multitarget evaluation of thiosemicarbazone-sulfonamide hybrids as potent cholinesterase and MAO-A inhibitors with neuroblastoma-associated cytotoxicity - Abbas_2026_Sci.Rep__ |
| Author(s) : Abbas K , Elamin MR , Senol H , Cakir F , Taslimi P , Tokali FS , Raza N , Salem ME , Alharthy RD , Rasool A , Shafiq Z |
| Ref : Sci Rep , : , 2026 |
| Abstract : |
| PubMedSearch : Abbas_2026_Sci.Rep__ |
| PubMedID: 42115356 |