FAPI-02
General
Type : Piperazine, Quinoline, PET probe, Carboxamide, Tetrazacyclododec, Cyanide
Chemical_Nomenclature : 2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[4-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
Canonical SMILES : C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)OCCCN4CCN(CC4)C(=O)CN5CCN(CCN(CCN(CC5)CC(=O)O)CC(=O)O)CC(=O)O)C#N
InChI : InChI=1S\/C40H56N10O10\/c41-24-30-3-1-9-50(30)35(51)25-43-40(59)32-6-7-42-34-5-4-31(23-33(32)34)60-22-2-8-44-18-20-49(21-19-44)36(52)26-45-10-12-46(27-37(53)54)14-16-48(29-39(57)58)17-15-47(13-11-45)28-38(55)56\/h4-7,23,30H,1-3,8-22,25-29H2,(H,43,59)(H,53,54)(H,55,56)(H,57,58)\/t30-\/m0\/s1
InChIKey : CRWOFMLXEOYIEP-PMERELPUSA-N
Other name(s) : FAPI-2 || 2370952-98-8 || UNII-54MD7EU3MC || 54MD7EU3MC || SCHEMBL21257060 || EX-A5966
MW : 836.9g\/mol
Formula : C40H56N10O10
CAS_number :
PubChem : 138454802
UniChem : CRWOFMLXEOYIEP-PMERELPUSA-N
Target
Families : FAPI-02 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-FAP
References (7)
| Title : An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use - Morandeau_2024_J.Vis.Exp__ |
| Author(s) : Morandeau L , Ioppolo JA , Alvarez de Eulate E , Mohamed S , Cullen D , Asad AH , Francis RJ , Atkinson J |
| Ref : J Vis Exp , : , 2024 |
| Abstract : |
| PubMedSearch : Morandeau_2024_J.Vis.Exp__ |
| PubMedID: 38856210 |
| Title : A Head-to-Head Comparison of 68Ga-LNC1007 and 2-18F-FDG\/68Ga-FAPI-02 PET\/CT in Patients With Various Cancers - Zang_2023_Clin.Nucl.Med_48_861 |
| Author(s) : Zang J , Lin R , Wen X , Wang C , Zhao T , Jakobsson V , Yang Y , Wu X , Guo Z , Chen X , Zhang J , Miao W |
| Ref : Clin Nucl Med , 48 :861 , 2023 |
| Abstract : |
| PubMedSearch : Zang_2023_Clin.Nucl.Med_48_861 |
| PubMedID: 37682601 |
| Title : [(68)Ga]Ga-HBED-CC-FAPI Derivatives with Improved Radiolabeling and Specific Tumor Uptake - Hong_2023_Mol.Pharm_20_2159 |
| Author(s) : Hong H , Zha Z , Zhao R , Luo Y , Jin W , Li L , Wang R , Yan L , Wang H , Ploessl K , Qiao J , Zhu L , Kung HF |
| Ref : Mol Pharm , 20 :2159 , 2023 |
| Abstract : |
| PubMedSearch : Hong_2023_Mol.Pharm_20_2159 |
| PubMedID: 36942924 |
| Title : Subclass Analysis of Malignant, Inflammatory and Degenerative Pathologies Based on Multiple Timepoint FAPI-PET Acquisitions Using FAPI-02, FAPI-46 and FAPI-74 - Glatting_2022_Cancers.(Basel)_14_ |
| Author(s) : Glatting FM , Hoppner J , Kauczor HU , Huber PE , Kratochwil C , Giesel FL , Haberkorn U , Rohrich M |
| Ref : Cancers (Basel) , 14 : , 2022 |
| Abstract : |
| PubMedSearch : Glatting_2022_Cancers.(Basel)_14_ |
| PubMedID: 36358720 |
| Title : Repetitive Early (68)Ga-FAPI PET Acquisition Comparing (68)Ga-FAPI-02, (68)Ga-FAPI-46, and (68)Ga-FAPI-74: Methodologic and Diagnostic Implications for Malignant, Inflammatory\/Reactive, and Degenerative Lesions - Glatting_2022_J.Nucl.Med_63_1844 |
| Author(s) : Glatting FM , Hoppner J , Liew DP , van Genabith A , Spektor AM , Steinbach L , Hubert A , Kratochwil C , Giesel FL , Dendl K , Rathke H , Kauczor HU , Huber PE , Haberkorn U , Rohrich M |
| Ref : J Nucl Med , 63 :1844 , 2022 |
| Abstract : |
| PubMedSearch : Glatting_2022_J.Nucl.Med_63_1844 |
| PubMedID: 35618480 |
| Title : Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [(68)Ga]Ga-FAPI-RGD - Zang_2022_Theranostics_12_7180 |
| Author(s) : Zang J , Wen X , Lin R , Zeng X , Wang C , Shi M , Zhang J , Wu X , Zhang X , Miao W , Xu P , Guo Z , Chen X |
| Ref : Theranostics , 12 :7180 , 2022 |
| Abstract : |
| PubMedSearch : Zang_2022_Theranostics_12_7180 |
| PubMedID: 36276644 |
| Title : IDH-wildtype glioblastomas and grade III\/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein-specific PET\/CT - Rohrich_2019_Eur.J.Nucl.Med.Mol.Imaging_46_2569 |
| Author(s) : Rohrich M , Loktev A , Wefers AK , Altmann A , Paech D , Adeberg S , Windisch P , Hielscher T , Flechsig P , Floca R , Leitz D , Schuster JP , Huber PE , Debus J , von Deimling A , Lindner T , Haberkorn U |
| Ref : Eur J Nucl Med Mol Imaging , 46 :2569 , 2019 |
| Abstract : |
| PubMedSearch : Rohrich_2019_Eur.J.Nucl.Med.Mol.Imaging_46_2569 |
| PubMedID: 31388723 |