FP30
FP30 (BRP-821) exhibited exceptional sub-nM sEH inhibitory activity (IC50 = 0.4 nM), along with excellent metabolic stability in human liver microsomes (t1/2 > 184 min, ER < 0.27) and high solubility in simulated intestinal fluid (108 microM)
General
Type : Imidazole, Cyclopropyl, Trifluoro, Carboxamide
Chemical_Nomenclature : 2-(4-(1-(Difluoromethyl)cyclopropyl)benzyl)-N-(4-methoxy-2-(trifluoromethyl)benzyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamide
Canonical SMILES : C1(=CC=C(C=C1)CC3=NC2=CC(=CC=C2[N]3C)C(NCC4=C(C=C(C=C4)OC)C(F)(F)F)=O)C5(CC5)C(F)F
InChI : InChI=1S\/C29H26F5N3O2\/c1-37-24-10-6-18(26(38)35-16-19-5-9-21(39-2)15-22(19)29(32,33)34)14-23(24)36-25(37)13-17-3-7-20(8-4-17)28(11-12-28)27(30)31\/h3-10,14-15,27H,11-13,16H2,1-2H3,(H,35,38)
InChIKey : OVWYVJGYZUWSDP-UHFFFAOYSA-N
Other name(s) : BRP-821
Target
Families : FP30 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (3)
| Title : Harnessing structure-activity relationships to repurpose the FLAP inhibitor BRP-7 into potent and selective sEH inhibitors - Caliskan_2025_Bioorg.Chem_165_108997 |
| Author(s) : Caliskan K , Karatas M , Jordan PM , Caliskan B , Werz O , Banoglu E |
| Ref : Bioorg Chem , 165 :108997 , 2025 |
| Abstract : |
| PubMedSearch : Caliskan_2025_Bioorg.Chem_165_108997 |
| PubMedID: 40974655 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Harnessing structure-activity relationships to repurpose the FLAP inhibitor BRP-7 into potent and selective sEH inhibitors - Caliskan_2025_Bioorg.Chem_165_108997 |
| Author(s) : Caliskan K , Karatas M , Jordan PM , Caliskan B , Werz O , Banoglu E |
| Ref : Bioorg Chem , 165 :108997 , 2025 |
| Abstract : |
| PubMedSearch : Caliskan_2025_Bioorg.Chem_165_108997 |
| PubMedID: 40974655 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Harnessing structure-activity relationships to repurpose the FLAP inhibitor BRP-7 into potent and selective sEH inhibitors - Caliskan_2025_Bioorg.Chem_165_108997 |
| Author(s) : Caliskan K , Karatas M , Jordan PM , Caliskan B , Werz O , Banoglu E |
| Ref : Bioorg Chem , 165 :108997 , 2025 |
| Abstract : |
| PubMedSearch : Caliskan_2025_Bioorg.Chem_165_108997 |
| PubMedID: 40974655 |
| Gene_locus related to this paper: human-EPHX2 |