Flucopride
donecopride derivative human-ACHE IC50 24 nM; human HTR4 - 5-hydroxytryptamine receptor 4 Ki 38 nM
General
Type : Multitarget, 5-HT-receptor-ligand, Piperidine
Chemical_Nomenclature : 1-(4-amino-5-fluoro-2-methoxyphenyl)-3-[1-(cyclohexylmethyl)piperidin-4-yl]propan-1-one
Canonical SMILES : COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CC3CCCCC3)F)N
InChI : InChI=1S\/C22H33FN2O2\/c1-27-22-14-20(24)19(23)13-18(22)21(26)8-7-16-9-11-25(12-10-16)15-17-5-3-2-4-6-17\/h13-14,16-17H,2-12,15,24H2,1H3
InChIKey : PXUUPGSNIMQISW-UHFFFAOYSA-N
Other name(s) : SCHEMBL17709643 || BDBM327448 || US9663465,5
MW : 376.5
Formula : C22H33FN2O2
CAS_number :
PubChem : 121301862
UniChem : PXUUPGSNIMQISW-UHFFFAOYSA-N
Target
Families : Flucopride ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT(4) receptors with potential interest in the treatment of Alzheimer's disease - Rochais_2024_Eur.J.Med.Chem_280_116975 |
| Author(s) : Rochais C , Lecoutey C , Lalut J , Davis A , Duval E , Gaven F , Largilliere S , Nee G , Corvaisier S , Sopkova de Oliveira Santos J , Since M , Freret T , Legrand R , Callizot N , Claeysen S , Boulouard M , Dallemagne P |
| Ref : Eur Journal of Medicinal Chemistry , 280 :116975 , 2024 |
| Abstract : |
| PubMedSearch : Rochais_2024_Eur.J.Med.Chem_280_116975 |
| PubMedID: 39454222 |