Fluoro-dihydroxy-biphenyl-tetradecan-one-oxime-Cpd14a
IC50 human-MGLL 0.68 +/- 0.01 microM rather specific FAAH 8.7 +/- 1.8 microM; ABHD6 >10 ABHD12 >10
General
Type : Tetradecanoate, Myristate, Biphenyl, Oxime
Chemical_Nomenclature : (E)-1-(3-fluoro-4,4-dihydroxy-[1,1-biphenyl]-3-yl)tetradecan-1-one oxime
Canonical SMILES : C1(=C(C=CC(=C1)C2=CC(=C(C=C2)O)F)O)C(=NO)CCCCCCCCCCCCC
InChI : InChI=1S\/C26H36FNO3\/c1-2-3-4-5-6-7-8-9-10-11-12-13-24(28-31)22-18-20(14-16-25(22)29)21-15-17-26(30)23(27)19-21\/h14-19,29-31H,2-13H2,1H3
InChIKey : HDOKJCNJHOXSDX-UHFFFAOYSA-N
Other name(s) : Compound 14a
Target
Families : Fluoro-dihydroxy-biphenyl-tetradecan-one-oxime-Cpd14a ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors - Bononi_2018_Eur.J.Med.Chem_157_817 |
| Author(s) : Bononi G , Granchi C , Lapillo M , Giannotti M , Nieri D , Fortunato S , Boustani ME , Caligiuri I , Poli G , Carlson KE , Kim SH , Macchia M , Martinelli A , Rizzolio F , Chicca A , Katzenellenbogen JA , Minutolo F , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 157 :817 , 2018 |
| Abstract : |
| PubMedSearch : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedID: 30144699 |