| Title : Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors - Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| Author(s) : Di Stefano M , Masoni S , Bononi G , Poli G , Galati S , Gado F , Manzi S , Vagaggini C , Brai A , Caligiuri I , Asif K , Rizzolio F , Macchia M , Chicca A , Sodi A , Di Bussolo V , Minutolo F , Meier P , Gertsch J , Granchi C , Dreassi E , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 263 :115916 , 2023 |
| Abstract : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| ESTHER : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedSearch : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedID: 37976705 |
| Title : Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives - Bononi_2022_J.Med.Chem__ |
| Author(s) : Bononi G , Di Stefano M , Poli G , Ortore G , Meier P , Masetto F , Caligiuri I , Rizzolio F , Macchia M , Chicca A , Avan A , Giovannetti E , Vagaggini C , Brai A , Dreassi E , Valoti M , Minutolo F , Granchi C , Gertsch J , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , : , 2022 |
| Abstract : Bononi_2022_J.Med.Chem__ |
| ESTHER : Bononi_2022_J.Med.Chem__ |
| PubMedSearch : Bononi_2022_J.Med.Chem__ |
| PubMedID: 35522977 |
| Title : Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Granchi_2020_Eur.J.Med.Chem_209_112857 |
| Author(s) : Granchi C , Bononi G , Ferrisi R , Gori E , Mantini G , Glasmacher S , Poli G , Palazzolo S , Caligiuri I , Rizzolio F , Canzonieri V , Perin T , Gertsch J , Sodi A , Giovannetti E , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Eur Journal of Medicinal Chemistry , 209 :112857 , 2020 |
| Abstract : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| ESTHER : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| PubMedSearch : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| PubMedID: 33045662 |
| Gene_locus related to this paper: human-MGLL |
| Title : Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system - Gado_2019_Bioorg.Chem__103353 |
| Author(s) : Gado F , Arena C , Fauci C , Reynoso-Moreno I , Bertini S , Digiacomo M , Meini S , Poli G , Macchia M , Tuccinardi T , Gertsch J , Chicca A , Manera C |
| Ref : Bioorg Chem , :103353 , 2019 |
| Abstract : Gado_2019_Bioorg.Chem__103353 |
| ESTHER : Gado_2019_Bioorg.Chem__103353 |
| PubMedSearch : Gado_2019_Bioorg.Chem__103353 |
| PubMedID: 31668465 |
| Title : Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors - Bononi_2018_Eur.J.Med.Chem_157_817 |
| Author(s) : Bononi G , Granchi C , Lapillo M , Giannotti M , Nieri D , Fortunato S , Boustani ME , Caligiuri I , Poli G , Carlson KE , Kim SH , Macchia M , Martinelli A , Rizzolio F , Chicca A , Katzenellenbogen JA , Minutolo F , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 157 :817 , 2018 |
| Abstract : Bononi_2018_Eur.J.Med.Chem_157_817 |
| ESTHER : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedSearch : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedID: 30144699 |
| Title : Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system - Chicca_2018_Eur.J.Med.Chem_154_155 |
| Author(s) : Chicca A , Arena C , Bertini S , Gado F , Ciaglia E , Abate M , Digiacomo M , Lapillo M , Poli G , Bifulco M , Macchia M , Tuccinardi T , Gertsch J , Manera C |
| Ref : Eur Journal of Medicinal Chemistry , 154 :155 , 2018 |
| Abstract : Chicca_2018_Eur.J.Med.Chem_154_155 |
| ESTHER : Chicca_2018_Eur.J.Med.Chem_154_155 |
| PubMedSearch : Chicca_2018_Eur.J.Med.Chem_154_155 |
| PubMedID: 29793210 |
| Title : Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors - Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| Author(s) : Aghazadeh Tabrizi M , Baraldi PG , Baraldi S , Ruggiero E , De Stefano L , Rizzolio F , Di Cesare Mannelli L , Ghelardini C , Chicca A , Lapillo M , Gertsch J , Manera C , Macchia M , Martinelli A , Granchi C , Minutolo F , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , 61 :1340 , 2018 |
| Abstract : Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| ESTHER : Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| PubMedSearch : Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| PubMedID: 29309142 |
| Title : Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity - Soethoudt_2017_Nat.Commun_8_13958 |
| Author(s) : Soethoudt M , Grether U , Fingerle J , Grim TW , Fezza F , De Petrocellis L , Ullmer C , Rothenhausler B , Perret C , van Gils N , Finlay D , MacDonald C , Chicca A , Gens MD , Stuart J , de Vries H , Mastrangelo N , Xia L , Alachouzos G , Baggelaar MP , Martella A , Mock ED , Deng H , Heitman LH , Connor M , Di Marzo V , Gertsch J , Lichtman AH , Maccarrone M , Pacher P , Glass M , van der Stelt M |
| Ref : Nat Commun , 8 :13958 , 2017 |
| Abstract : Soethoudt_2017_Nat.Commun_8_13958 |
| ESTHER : Soethoudt_2017_Nat.Commun_8_13958 |
| PubMedSearch : Soethoudt_2017_Nat.Commun_8_13958 |
| PubMedID: 28045021 |
| Title : Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases - Chicca_2016_Recent.Pat.CNS.Drug.Discov_10_122 |
| Author(s) : Chicca A , Arena C , Manera C |
| Ref : Recent Pat CNS Drug Discov , 10 :122 , 2016 |
| Abstract : Chicca_2016_Recent.Pat.CNS.Drug.Discov_10_122 |
| ESTHER : Chicca_2016_Recent.Pat.CNS.Drug.Discov_10_122 |
| PubMedSearch : Chicca_2016_Recent.Pat.CNS.Drug.Discov_10_122 |
| PubMedID: 27630088 |
| Title : Functionalization of beta-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System - Chicca_2014_ACS.Chem.Biol_9_1499 |
| Author(s) : Chicca A , Caprioglio D , Minassi A , Petrucci V , Appendino G , Taglialatela-Scafati O , Gertsch J |
| Ref : ACS Chemical Biology , 9 :1499 , 2014 |
| Abstract : Chicca_2014_ACS.Chem.Biol_9_1499 |
| ESTHER : Chicca_2014_ACS.Chem.Biol_9_1499 |
| PubMedSearch : Chicca_2014_ACS.Chem.Biol_9_1499 |
| PubMedID: 24831513 |