| Title : Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors - Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| Author(s) : Di Stefano M , Masoni S , Bononi G , Poli G , Galati S , Gado F , Manzi S , Vagaggini C , Brai A , Caligiuri I , Asif K , Rizzolio F , Macchia M , Chicca A , Sodi A , Di Bussolo V , Minutolo F , Meier P , Gertsch J , Granchi C , Dreassi E , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 263 :115916 , 2023 |
| Abstract : |
| PubMedSearch : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedID: 37976705 |
| Title : A carrier free delivery system of a monoacylglycerol lipase hydrophobic inhibitor - Adeel_2022_Int.J.Pharm_613_121374 |
| Author(s) : Adeel M , Saorin G , Boccalon G , Sfriso AA , Parisi S , Moro I , Palazzolo S , Caligiuri I , Granchi C , Corona G , Cemazar M , Canzonieri V , Tuccinardi T , Rizzolio F |
| Ref : Int J Pharm , 613 :121374 , 2022 |
| Abstract : |
| PubMedSearch : Adeel_2022_Int.J.Pharm_613_121374 |
| PubMedID: 34906647 |
| Title : Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives - Bononi_2022_J.Med.Chem__ |
| Author(s) : Bononi G , Di Stefano M , Poli G , Ortore G , Meier P , Masetto F , Caligiuri I , Rizzolio F , Macchia M , Chicca A , Avan A , Giovannetti E , Vagaggini C , Brai A , Dreassi E , Valoti M , Minutolo F , Granchi C , Gertsch J , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , : , 2022 |
| Abstract : |
| PubMedSearch : Bononi_2022_J.Med.Chem__ |
| PubMedID: 35522977 |
| Title : Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold - Bononi_2021_Eur.J.Med.Chem_223_113679 |
| Author(s) : Bononi G , Tonarini G , Poli G , Barravecchia I , Caligiuri I , Macchia M , Rizzolio F , Demontis GC , Minutolo F , Granchi C , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 223 :113679 , 2021 |
| Abstract : |
| PubMedSearch : Bononi_2021_Eur.J.Med.Chem_223_113679 |
| PubMedID: 34218085 |
| Title : Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Granchi_2020_Eur.J.Med.Chem_209_112857 |
| Author(s) : Granchi C , Bononi G , Ferrisi R , Gori E , Mantini G , Glasmacher S , Poli G , Palazzolo S , Caligiuri I , Rizzolio F , Canzonieri V , Perin T , Gertsch J , Sodi A , Giovannetti E , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Eur Journal of Medicinal Chemistry , 209 :112857 , 2020 |
| Abstract : |
| PubMedSearch : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| PubMedID: 33045662 |
| Gene_locus related to this paper: human-MGLL |
| Title : Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor - Granchi_2019_J.Med.Chem_62_1932 |
| Author(s) : Granchi C , Lapillo M , Glasmacher S , Bononi G , Licari C , Poli G , El Boustani M , Caligiuri I , Rizzolio F , Gertsch J , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Journal of Medicinal Chemistry , 62 :1932 , 2019 |
| Abstract : |
| PubMedSearch : Granchi_2019_J.Med.Chem_62_1932 |
| PubMedID: 30715876 |
| Title : Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| Author(s) : Poli G , Lapillo M , Jha V , Mouawad N , Caligiuri I , Macchia M , Minutolo F , Rizzolio F , Tuccinardi T , Granchi C |
| Ref : J Enzyme Inhib Med Chem , 34 :589 , 2019 |
| Abstract : |
| PubMedSearch : Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| PubMedID: 30696302 |
| Gene_locus related to this paper: human-MGLL |
| Title : Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors - Bononi_2018_Eur.J.Med.Chem_157_817 |
| Author(s) : Bononi G , Granchi C , Lapillo M , Giannotti M , Nieri D , Fortunato S , Boustani ME , Caligiuri I , Poli G , Carlson KE , Kim SH , Macchia M , Martinelli A , Rizzolio F , Chicca A , Katzenellenbogen JA , Minutolo F , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 157 :817 , 2018 |
| Abstract : |
| PubMedSearch : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedID: 30144699 |
| Title : Rational Development of MAGL Inhibitors - Granchi_2018_Methods.Mol.Biol_1824_335 |
| Author(s) : Granchi C , Rizzolio F , Caligiuri I , Macchia M , Martinelli A , Minutolo F , Tuccinardi T |
| Ref : Methods Mol Biol , 1824 :335 , 2018 |
| Abstract : |
| PubMedSearch : Granchi_2018_Methods.Mol.Biol_1824_335 |
| PubMedID: 30039417 |
| Title : A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017) - Granchi_2017_Expert.Opin.Ther.Pat_27_1341 |
| Author(s) : Granchi C , Caligiuri I , Minutolo F , Rizzolio F , Tuccinardi T |
| Ref : Expert Opin Ther Pat , 27 :1341 , 2017 |
| Abstract : |
| PubMedSearch : Granchi_2017_Expert.Opin.Ther.Pat_27_1341 |
| PubMedID: 29053063 |
| Title : 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors - Granchi_2016_J.Enzyme.Inhib.Med.Chem_31_137 |
| Author(s) : Granchi C , Rizzolio F , Bordoni V , Caligiuri I , Manera C , Macchia M , Minutolo F , Martinelli A , Giordano A , Tuccinardi T |
| Ref : J Enzyme Inhib Med Chem , 31 :137 , 2016 |
| Abstract : |
| PubMedSearch : Granchi_2016_J.Enzyme.Inhib.Med.Chem_31_137 |
| PubMedID: 25669350 |
| Title : Identification and characterization of a new reversible MAGL inhibitor - Tuccinardi_2014_Bioorg.Med.Chem_22_3285 |
| Author(s) : Tuccinardi T , Granchi C , Rizzolio F , Caligiuri I , Battistello V , Toffoli G , Minutolo F , Macchia M , Martinelli A |
| Ref : Bioorganic & Medicinal Chemistry , 22 :3285 , 2014 |
| Abstract : |
| PubMedSearch : Tuccinardi_2014_Bioorg.Med.Chem_22_3285 |
| PubMedID: 24853323 |